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9篇 您的检索式：作者名="Malik Peiris JS"

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		题名	作者	年代	出处	被引量
	1	Avian influenza virus directly infects human natural killer cells and inhibits cell activity显示文摘Natural killer(NK) cell is a key component of innate immunity and plays an important role in host defense against virus infection by directly destroying infected cells. Influenza is a respiratory disease transmitted in the early phase of virus infection. Evasion of host innate immunity including NK cells is critical for the virus to expand and establish a successful acute infection. Previously,we showed that human influenza H1N1 virus infects NK cells and induces cell apoptosis, as well as inhibits NK cell activity. In this study, we further demonstrated that avian influenza virus also directly targeted NK cells as an immunoevasion strategy. The avian virus infected human NK cells and induced cell apoptosis. In addition, avian influenza virion and HA protein inhibited NK cell cytotoxicity. This novel strategy has obvious advantages for avian influenza virus, allowing the virus sufficient time to expand and subsequent spread before the onset of the specific immune response. Our findings provide an important clue for the immunopathogenesis of avian influenza,and also suggest that direct targeting NK cells may be a common strategy used by both human and avian influenza viruses to evade NK cell immunity.	Huawei Mao Yinping Liu Sin Fun Sia JS Malik Peiris Yu-Lung Lau Wenwei Tu	2017	Virologica Sinica2017，32，2：	4
	2	Avian influenza viruses in humans 显示文摘	Malik Peiris JS	2009	Rev Sci Tech2009，28，1：	1
	3	Avian influenza viruses in humans 显示文摘	Malik Peiris JS	2009	Rev Sci Tech2009，28，1：	1
	4	Avian influenza virues in humans 显示文摘	Malik Peiris JS	2009	Rev Sci Tech2009，28，1：	1
	5	A novel H1N1 virus causes the first pandemic of the 21 st century显示文摘	JS Malik Peiris Wen -wei Tu Hui - ling Yen	2009	European J I mmunol2009，39，：	1
	6	Avian influenza viruses in humans 显示文摘	Malik Peiris JS	2009	Rev Sci Tech2009，28，1：	1
	7	Avian influenza virues in humans 显示文摘	Malik Peiris JS	2009	Rev Sci Tech2009，28，1：	1
	8	pneumonia research to reduce childhood mortality in the developing world 显示文摘	Anthony G Scott W Abdullah Brooks JS Malik Peiris	2008	Clin Invest2008，，4：	1
	9	Pneumonia research to reduce childhood mortality in the developing world 显示文摘	J Anthony G Scott W Abdullah Brooks JS Malik Peiris	2008	The Journal of Clinical Investigation2008，118，4：	1

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