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| 1 | Gene and cell therapy based treatment strategies for inflammatory bowel diseases显示文摘Inflammatory bowel diseases(IBD)are a group of chronic inflammatory disorders most commonly affecting young adults.Currently available therapies can result in induction and maintenance of remission,but are not curative and have sometimes important side effects.Advances in basic research in IBD have provided new therapeutic opportunities to target the inflammatory process involved.Gene and cell therapy approaches are suitable to prevent inflammation in the gastrointestinal tract and show therefore potential in the treatment of IBD.In this review,we present the current progress in the field of both gene and cell therapy and future prospects in the context of IBD.Regarding gene therapy,we focus on viral vectors and their applications in preclinical models.The focus for cell therapy is on regulatory T lymphocytes and mesenchymal stromal cells,their potential for the treatment of IBD and the progress made in both preclinical models and clinical trials. | Sander van der Marel Anna Majowicz Sander van Deventer Harald Petry Daniel W Hommes Valerie Ferreira | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 3 |
| 2 | The global burden of nontyphoidal Salmonella gastroenteritis 显示文摘 | Majowicz SE Musto J Scallan E et ol | 2010 | Clin Infect Dis2010，50，6： | 1 |
| 3 | Burden of acute gastro-intestinal illness in Canada, 1999 - 2007:interim summary of NSAGIactivities 显示文摘 | Thomas MK Majowicz SE Pollari F | 2008 | Can Commun Dis Rep2008，34，5： | 1 |
| 4 | The global burden of nontyphoidal Salmonella gastroen- teritis显示文摘 | MAJOWICZ S E MUSTO J SCALLAN E | 2010 | Clin Infect Dis2010，50，6： | 1 |
| 5 | The global burden of nontyphoidal salmonella gastroenteritis 显示文摘 | Majowicz SE Musto J Scallan E | 2010 | Clinl Infect Dis2010，50，6： | 1 |
| 6 | Prevalence of diarrhoea in the community in Australia, Canada, Ireland and the United States显示文摘 | Scallan E Majowicz SE Hall G | 2005 | Int J Epidemiol2005，34，45： | 1 |
| 7 | The global burden of nontyphoidal Salmonella gastroenteritis显示文摘 | MAJOWICZ SE MUSTO J SCALLAN E | 2010 | Clin Infect Dis2010，50，6： | 1 |
| 8 | The global burden of nontyphoidal Salmonella gastroenteritis显示文摘 | Majowicz S E Musto J Scallan E | 2010 | Clin Infect Dis2010，50，6： | 1 |
| 9 | Magnitude and Distribution of Acute, Self-reported gastrointestinal illness in a Canadian community 显示文摘 | MAJOWICZ S E DORE K FLINT J A | 2004 | Epidemiol Infect2004，132，： | 1 |
| 10 | The global burden ofnontyp- hoidal Salmonella gastroenteritis 显示文摘 | Majowicz S E Musto J Scallan E | 2010 | Clin Infect Dis2010，50，： | 1 |
| 11 | Magnitude and distribution of acute, self-reported gastrointestinal illness in a Canadian com- munity显示文摘 | Majowicz SE Dor6 K Flint JA | 2004 | Epidemiol Infect2004，132，4： | 1 |
| 12 | Gene and cell therapy based treatment strategies for inflammatory bowel diseases 显示文摘 | VAN DER MAREL S MAJOWICZ A VAN DEVENTER S | 2011 | World J Gastrointest Pathophysiol2011，2，6： | 1 |
| 13 | The global burden of nontyphoidal Salmonella gastroenteritis 显示文摘 | MAJOWICZ S E MUSTO J SCALLAN E | 2010 | Clin Infect Dis2010，50，6： | 1 |
| 14 | The burden of acute gastrointestinal illness in Ontario, Canada, 2005 - 2006 显示文摘 | Sargeant JM Majowicz SE Snelgrove J | 2008 | Epiderniol Infect2008，136，4： | 1 |
| 15 | The global burden ofnontyphoidal Salmonella gastroenteritis 显示文摘 | Majowicz S E Musto J Scallan E | 2010 | Clin Infect Dis2010，50，6： | 1 |
| 16 | Magnitude and distribution of acute, self - reported gastrointestinal illness in a Canadian community显示文摘 | Majowicz SE Dore K Flint JA | 2004 | Epidemiol Infect2004，132，4： | 1 |
| 17 | Demographic determinants of acute gastrointestinal illness in Canada: a population study 显示文摘 | Majowicz SE Horrocks J Bocking K | 2007 | BMC Public Health2007，18，7： | 1 |
| 18 | Atrial natriuretic peptide modifies arterial blood pressure through nitricoxide pathway in rats显示文摘 | Osta MD Bosc LV Majowicz MP | 2000 | Hypertension2000，35，5： | 1 |
| 19 | Prevalence of diarrhoea in the community in Australia,Canada, Ireland,and the Unit- ed States显示文摘 | Scallan E Majowicz S E Hall G | 2005 | Int J Epidemiol2005，34，2： | 1 |
| 20 | Estimatednumbers of community cases of illness due to Salmonella,Campylobacter and Verotoxigenic Escherichia coli : pathogen-specific community rates 显示文摘 | Thomas M K Majowicz S E Sockett P N | 2006 | Can J Infect Dis Med Microbiol2006，17，4： | 1 |
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