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| 1 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 2 | Bevacizumab (Avastin) eye drops inhibit corneal neovascularization显示文摘 | Felix Bock Yanyan K?nig Friedrich Kruse Martin Baier Claus Cursiefen | 2008 | Graefe’s Archive for Clinical and Experimental Ophthalmology2008，，2： | 2 |
| 3 | High Prevalence of Viral Genomes and Multiple Viral Infections in the Myocardium of Adults With “Idiopathic” Left Ventricular Dysfunction显示文摘 | Uwe Kühl Matthias Pauschinger Michel Noutsias Bettina Seeberg Thomas Bock Dirk Lassner Wolfgang Poller Reinhard Kandolf Heinz-Peter Schultheiss | 2005 | Circulation2005，，7： | 2 |
| 4 | Expression of cell volume-regulated kinase h-SGK in pancreatic tissue显示文摘 | KLINGEL K WARNTGES S BOCK J | 2000 | Am J Physiol Gastrointest Liver Physiol2000，279，5： | 1 |
| 5 | Bronchial artery revascular- ization restores peribronchial tissue oxygenation after lung trans- plantation 显示文摘 | Kamler M nowak K Bock M | 2004 | J Heart Lung Translplant2004，23，6： | 1 |
| 6 | Coordinate regulation of hu-man drug-metabolizing enzymes,and conjugatetransporters by the Ah receptor,pregnane X recep-tor and constitutive androstane receptor显示文摘 | Khle C Bock KW | 2009 | Bio-chem Pharmacol2009，77，4： | 1 |
| 7 | Concomitant administration of varicella vaccine with combined measles,mumps and rubella vaccine in healthy children aged 12 to 24 months of age显示文摘 | Stuck B Stehr K Bock HL | | 0，，02： | 1 |
| 8 | Carbohydrate structuraldetermination by NMR spectroscopy : modern methods andlimitations显示文摘 | Duus J Gotfredsen C H Bock K | 2000 | Chem Rev2000，100，45： | 1 |
| 9 | Rocuronium potency and recovery characteristics during steady- state desflurane, sevoflurane, isoflurane or propofol anaesthesia 显示文摘 | Bock M Klippel K Nitsche B | 2000 | Br J Anaesth2000，84，1： | 1 |
| 10 | Semipermeable glove mem-branes-effects on skin barrier repair following SLS irritation 显示文摘 | Bock M Damer K Wulfhorst B | 2009 | Contact Dermatitis2009，61，5： | 1 |
| 11 | Tissue- and stage-specific modulation of RNA editing of the psbF and psbL transcript from spinach plastids-a new regulatory mechanism?显示文摘 | Bock R Hagemann R K?ssel H Kudla J | 1993 | Mol Gen Genet1993，240，2： | 1 |
| 12 | Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc显示文摘 | Bock F Shahzad K Wang H | | 0，，： | 1 |
| 13 | Molecular farming for new drugs and vaccines-Current perspectives on the production of pharmaceuticals in transgenic plants显示文摘 | Ma J K C Barros E Bock R | 2005 | EMBO Rep2005，6，7： | 1 |
| 14 | Human papillomavirus-the moet significant risk determinant of cervical intraepithelial neoplasia显示文摘 | KJAER S K BRULE A J C BOCK J E | 1996 | Int J Cancer1996，65，： | 1 |
| 15 | In vitro corneal permeability of diclofenac sodium in formulations containing cyclodextrins compared to the commercial product voltaren ophtha 显示文摘 | Reer O Bock T K Muller B W | 1994 | Journal of Pharmaceutic Sciences1994，83，9： | 1 |
| 16 | Iron isomahoside 1000: a new high dose option for parenteral iron therapy显示文摘 | KALRA PA BOCK K MELDAL M | 2012 | Portuguese J Nephrol Hypertens2012，26，1： | 1 |
| 17 | Nlrp3- inflammasomeactivation in non- myeloidderived cells aggravates diabeticnephropathy显示文摘 | Shahzad K Bock F Dong W | 2015 | Kidney Int2015，87，1： | 1 |
| 18 | Taming plastids for a green future显示文摘 | BOCK R SARWAR K M | 2004 | Trends in Biotech2004，22，6： | 1 |
| 19 | Identification of spore aller- gens from the indoor mould Aspergillus versicolor显示文摘 | Benndorf D Miiller A Bock K | 2008 | Allergy2008，63，4： | 1 |
| 20 | Brain Research显示文摘 | Kφhler L B Berezin Vladimir Bock Elisabeth Milena Penkowa | 2003 | 992(1): 1282003，992，1： | 1 |
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