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| 1 | ABCD^(2) risk score does not predict the presence of cerebral microemboli in patients with hyper-acute symptomatic critical carotid artery stenosis显示文摘Introduction:ABCD^(2) risk score and cerebral microemboli detected by transcranial Doppler(TCD)have been separately shown to the predict risk of recurrent acute stroke.We studied whether ABCD2 risk score predicts cerebral microemboli in patients with hyper-acute symptomatic carotid artery stenosis.Participants and methods:We studied 206 patients presenting within 2 weeks of transient ischaemic attack or minor stroke and found to have critical carotid artery stenosis(≥50% ).86 patients(age 70±1(SEM:years),58 men,83 Caucasian)had evidence of microemboli;72(84% )of these underwent carotid endarterectomy(CEA).120 patients(age 72±1 years,91 men,113 Caucasian)did not have microemboli detected;102(85% )of these underwent CEA.Data were analysed using X2 and Mann–Whitney U tests and receiver operating characteristic(ROC)curves.Results:140/206(68% :95% CI 61.63 to 74.37)patients with hyper-acute symptomatic critical carotid stenosis had an ABCD2 risk score≥4.There was no significant difference in the NICE red flag criterion for early assessment(ABCD^(2) risk score≥4)for patients with cerebral microemboli versus those without microemboli(59/86 vs 81/120 patients:OR 1.05 ABCD2 risk score≥4(95% CI 0.58 to 1.90,p=0.867)).The ABCD2 risk score was<4 in 27 of 86(31% :95% CI 21 to 41)embolising patients and in 39 of 120(31% :95% CI 23 to 39)without cerebral microemboli.After adjusting for pre-neurological event antiplatelet treatment(APT),area under the curve(AUC)of ROC for ABCD2 risk score showed no prediction of cerebral microemboli(no pre-event APT,n=57:AUC 0.45(95% CI 0.29 to 0.60,p=0.531);preevent APT,n=147:AUC 0.51(95% CI 0.42 to 0.60,p=0.804)).Conclusions:The ABCD2 score did not predict the presence of cerebral microemboli or carotid disease in over one-quarter of patients with symptomatic critical carotid artery stenosis.On the basis of NICE guidelines(refer early if ABCD2≥4),assessment of high stroke risk based on ABCD2 scoring may lead to inappropriate delay in urgent treatment in many patients. | Mahmud Saedon Charles E Hutchinson Christopher H E Imray Donald R J Singer | 2017 | Stroke & Vascular Neurology2017，2，2： | 6 |
| 2 | Imaging vulnerable plaque by ultrasound显示文摘 | Demaria AN Narula J Mahmud E | 2006 | J Am Coll Cardiol2006，47，： | 1 |
| 3 | Clinical efficacy of drug-eluting stents in diabetic patients:a Ma- ta-analysis显示文摘 | Mahmud E Bromberg-Marin G Palakodeti V | 2008 | J Am Coll Cardiol2008，51，25： | 1 |
| 4 | Human papillomavirus infections with multiple types and risk of cervical neoplasia 显示文摘 | Trottier H Mahmud S Costa MC Sobfinho JP Duarte - Franco E Rohan TE | 2006 | Cancer Epidemiol Biomarkers Prey2006，15，： | 1 |
| 5 | D ilation of the coronary sinus on chocardiogram:prevalence and significance in patients with chronic pulmonary hypertension 显示文摘 | Mahmud E Raisinghani A Keramati S | 2001 | J Am Soc Echocardiogr2001，14，： | 1 |
| 6 | Effect of prehos- pital 12--lead electrocardiogram on activation of the cardiac catheterization laboratory and door--to--balloon time in ST --segment elevation acute myocardial infraction显示文摘 | Brown JP Mahmud E Dunford JV | 2008 | Am J Cardiol2008，101，2： | 1 |
| 7 | Imaging vulnerable plaque by ultrasound显示文摘 | DeMaria AN Narula J Mahmud E | 2006 | J Am Coil Cardiol2006，47，8： | 1 |
| 8 | Elevated serum fibrinogen: an Independent Link between diabetes mellitus, impaired on-clopidogrel platelet in- hibition, mad major adverse cardiac events after percutaneous coro- nary intervention显示文摘 | ANG L MAHMUD E | 2015 | J Am Coll Cardio12015，65，16： | 1 |
| 9 | Imaging vulnerable plaque by ultrasound显示文摘 | DeMaria AN Narula J Mahmud E | 2006 | J Am Coll Cardiol2006，47，8： | 1 |
| 10 | Effect of prehospital 12-lead electrocardiogram on activation of the cardiac catheterization laboratory and door-to-balloon time in ST-segment elevation acute myocardial infarction 显示文摘 | Brown JP Mahmud E Dunford JV | 2008 | Am J Cardiol2008，101，2： | 1 |
| 11 | Correlation of left ventricular diastolic filling characteristics with right ventricular overload and pulmonary artery pressure in chronic thromboembolic pulmonary hypertension 显示文摘 | Mahmud E Raisinghani A Hassankhani A Sadeghi HM Strachan GM Auger W | 2002 | J Am Coil Cardiol2002，40，2： | 1 |
| 12 | The CO 2 capture performance of a high-intensity vortex spray scrubber 显示文摘 | Javed K H Mahmud T Purba E | 2010 | Chemical Engineering Journal2010，162，2： | 1 |
| 13 | Anemia characteristics after renal transplantation显示文摘 | Mahmud SN Aziz R Ahmed E | 2012 | Transplant Proc2012，34，6： | 1 |
| 14 | Correlation of left ventricular diastolic filling characteristics with right ventricular overload and pulmonary artery pressure in chronic thromboembolic pulmonary hypertension显示文摘 | Mahmud E Raisinghani A Hassankhani A | 2002 | J Am Coll Cardiol2002，40，2： | 1 |
| 15 | Stabilization of residual soil with rice husk ash and cement显示文摘 | Basha E A Hashim R Mahmud H B | 2005 | Construction and Building Materials2005，19，： | 1 |
| 16 | 查看详情显示文摘 | Hastings G W Mahmud E A | | 0，，： | 1 |
| 17 | self-healing behavioring of nano-ceramics/carbon composites during oxidation显示文摘 | Hastings G W Mahmud E A | 1998 | Intelligent Material Systems and structures1998，4，3： | 1 |
| 18 | Ue of nonsteroidal anti-inflammatory drugs an prostate cancer risk: a meta-analysis 显示文摘 | Mahmud S M Franco E L Aprikian A G | 2010 | Int J Cancer2010，127，7： | 1 |
| 19 | Evaluation of Anti-CCP antibody for diagnosis of rheumatoid arthritis 显示文摘 | AFZAL N KARIM S MAHMUD T E | 2011 | Clin Lab2011，57，1112： | 1 |
| 20 | Intelligent orthopaedic materials显示文摘 | Hastings G W Mahmud E A | 1993 | Journal of Intelligent Material Systems and Structures1993，4，3： | 1 |
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