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| 1 | Antioxidant therapy in acute,chronic and post-endoscopic retrograde cholangiopancreatography pancreatitis:An updated systematic review and meta-analysis显示文摘AIM:To investigate the efficacy and adverse effects of antioxidant therapy in acute pancreatitis(AP),chronic pancreatitis(CP) and post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP).METHODS:Pub Med,Scopus,Google Scholar,Cochrane library database,and Evidence-based medicine/clinical trials published before August 2014 were searched. Clinical and laboratory outcomes of randomized trials of antioxidant therapy in patients with AP,CP and PEP were included. The methodological quality of the trials was assessed by the Jadad score based on the description of randomization,blinding,and dropouts(withdrawals). The results of the studies were pooled and meta-analyzed to provide estimates of the efficacy of antioxidant therapy.RESULTS:Thirty four trials out of 1069 potentially relevant studies with data for 4898 patients wereeligible for inclusion. Antioxidant therapy significantly reduced the length of hospital stay in AP patients {mean difference-2.59 d(95%CI:-4.25-(-0.93)],P = 0.002}. Although,antioxidant therapy had no significant effect on serum C reactive protein(CRP) after 5-7 d in AP patients [mean difference-9.57(95%CI:-40.61-21.48,P = 0.55],it significantly reduced serum CRP after 10 d {mean difference-45.16 [95%CI:-89.99-(-0.33)],P = 0.048}. In addition,antioxidant therapy had no significant effect on CP-induced pain [mean difference-2.13(95%CI:-5.87-1.6),P = 0.26]. Antioxidant therapy had no significant effects on the incidence of all types of PEP [mean difference 1.05(95%CI:0.74-1.5),P = 0.78],severe PEP [mean difference 0.92(95%CI:0.43-1.97),P = 0.83],moderate PEP [mean difference 0.82(95%CI:0.54-1.23),P = 0.33],and mild PEP [mean difference 1.33(95%CI:0.99-1.78),P = 0.06]. Furthermore,while antioxidant therapy had no significant effect on serum amylase after less than 8 h sampling [mean difference-20.61(95%CI:-143.61-102.39),P = 0.74],it significantly reduced serum amylase close to 24-h sampling {mean difference-16.13 [95%CI:-22.98-(-9.28)],P < 0.0001}.CONCLUSION:While there is some evidence to support antioxidant therapy in AP,its effect on CP and PEP is still controversial. | Maziar Gooshe Amir Hossein Abdolghaffari Shekoufeh Nikfar Parvin Mahdaviani Mohammad Abdollahi | 2015 | World Journal of Gastroenterology2015，21，30： | 6 |
| 2 | IL-10, TGF-beta, IL-2, IL-12, and IFN-gamma, cytokine gene polymorphisms in asth- ma 显示文摘 | Movahedi M Mahdaviani S A Rezaei N | 2008 | J Asthma2008，45，9： | 1 |
| 3 | ProinflammatoGrycytokinegenepolymorphismsamongIranianpatientswithasthma显示文摘 | MAHDAVIANIS REZAEIN MORADIB | 2009 | JClinImmunol2009，29，： | 1 |
| 4 | IL-10,TGF- beta, IL-2, IL-12, and IFN-gamma cytokine gene poly- morphisms in asthma显示文摘 | Movahedi M Mahdaviani SA Rezaei N | 2008 | J Asthma2008，45，9： | 1 |
| 5 | IL-10,TGF-beta,IL-2,IL-12,and IFN-gamma cytokine gene polymorphisms in asthma显示文摘 | MOVAHEDI M MAHDAVIANI S A REZAEI N | | 0，，09： | 1 |
| 6 | IL-10,TGF-beta,IL-2,IL-12,and IFN-gamma cytokine gene polymorphisms in asthma显示文摘 | Movahedi M Mahdaviani SA Rezaei N | 2008 | J Asthma2008，45，： | 1 |
| 7 | Inherited CARD9 de- ficiency in otherwise healthy children and adults with Candida spe- cies-induced meningoencephalitis, colitis, or both 显示文摘 | Lanternier F Mahdaviani SA Barbati E | 2015 | J Allergy Clin Immunol2015，135，6： | 1 |
| 8 | IL-10, TGF -beta, IL -2, IL- 12, and IFN -gamma, cytokine gene polymorphisms in asthma 显示文摘 | Movahedi M Mahdaviani SA Rezaei N | 2008 | J Asthma2008，45，9： | 1 |
| 9 | IL-10,TGF-?,IL-2,IL12,and IFN-Υ Cytokine Gene Polymorphisms in asthma显示文摘 | Movahedi M Mahdaviani SA Rezaei N | 2008 | J Asthma2008，459，9： | 1 |
| 10 | Serum thyroid stimulating hormone, total and free T4 during the neonatal period: Establishing regional reference intervals 显示文摘 | Sheikhbahaei S Mahdaviani B Abdollahi A | 2014 | Indian J Endocrinol Metab2014，18，1： | 1 |
| 11 | IL-10,TGF-β,IL-2,IL-12,and IFN-γcytokine gene polymorphisms in asthma显示文摘 | Movahedi M Mahdaviani SA Rezaei N | | 0，，09： | 1 |
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