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| 1 | 系统性药物治疗儿童银屑病的安全性显示文摘银屑病是一种常见的慢性炎症性皮肤病。成年人的发病率为2%~3%,其中大约有三分之一的患者在18岁之前发病。在儿童期,该病的发病率呈线性增长。从1970年至2000年,儿童银屑病的发病率增加了一倍多。尽管对许多轻度银屑病患儿而言,局部治疗已足够,但对更多可能影响生活质量的重度或顽固性的银屑病患儿,则往往需要系统性治疗。 | bronckers imgj seyger mmb west dp lara-corrales i tollefson m tom wl hogeling m belazarian l zachariae c mahé e siegfried e philipp s szalai z vleugels ra holland k murphy r baselga e cordoro k lambert j alexopoulos a mrowietz u kievit w paller as 邓婕(编译) 张锡宝(审校) 无 | 2017 | 皮肤性病诊疗学杂志2017，24，5： | 3 |
| 2 | An ORF2 protein-based ELISA for porcine circovirus type 2 antibodies in post-weaning multisystemic wasting syndrome显示文摘 | Ph Blanchard D Mahé R Cariolet C Truong M Le Dimna C Arnauld N Rose E Eveno E Albina F Madec A Jestin | 2003 | Veterinary Microbiology2003，，3： | 2 |
| 3 | Mechanisms of biofilm resistance to antimicrobial agents显示文摘 | Thien-Fah C Mah George A O’Toole | 2001 | Trends in Microbiology2001，，1： | 2 |
| 4 | Early dynamic transcriptomic changes during preoperative radiotherapy in patients with rectal cancer: A feasibility study显示文摘AIM: To develop novel biomarkers of rectal radiotherapy, we measured gene expression profiles on biopsies taken before and during preoperative radiotherapy. METHODS: Six patients presenting with a locally advanced rectal cancer (T>T2, N0/Nx, M0) eligible for preoperative radiotherapy (45 Gy in 25 fractions) were selected in a pilot study. Six tumor and 3 normal tissues biopsies were taken before and during radiotherapy,after a dose of 7.2 Gy at a median time of 1 h following irradiation (0:27-2:12). Tumor or normal tissue purity was assessed by a pathologist prior to RNA extraction. Mean RNA content was 23 μg/biopsy (14-37) before radiotherapy and 22.7 μg/biopsy (12-35) during radiotherapy. After RNA amplification, biopsies were analysed with 54K HG-U133A Plus 2.0 Affymetrix expression micro-arrays. Data were normalized according to MAS5 algorithm. A gene expression ratio was calculated as: (gene expression during radiotherapy-gene expression before radiotherapy)/gene expression before radiotherapy. Were selected genes that showed a ratio higher than ± 0.5 in all 6 patients. RESULTS: Microarray analysis showed that preoperative radiotherapy significantly up-regulated 31 genes and down-regulated 6 genes. According to the Gene Ontology project classification, these genes are involved in protein metabolism (ADAMDEC1 ; AKAP7 ; CAPN5 ; CLIC5 ; CPE ; CREB3L1 ; NEDD4L ; RAB27A), ion transport (AKAP7 ; ATP2A3 ; CCL28 ; CLIC5 ; F2RL2 ; NEDD4L ; SLC6A8), transcription (AKAP7 ; CREB3L1 ; ISX ; PAB-PC1L ; TXNIP), signal transduction (CAPN5 ; F2RL2 ; RA- B27A ; TNFRSF11A), cell adhesion (ADAMDEC1 ; PXDN ; SPON1 ; S100A2), immune response (CCL28 ; PXDN ; TNFRSF11A) and apoptosis (ITM2C ; PDCD4 ; PVT1). Up-regulation of 3 genes (CCL28 ; CLIC5 ; PDCD4) was detected by 2 different probes and up-regulation of 2 genes (RAB27A ; TXNIP) by 3 probes. CONCLUSION: Micro-arrays can efficiently assess early transcriptomic changes during preoperative radiotherapy for rectal cancer, and may help better understand tumor radioresistance. | Stephane Supiot Wilfried Gouraud Loc Campion Pascal Jezéquel Bruno Buecher Josiane Charrier Marie-Francoise Heymann Marc-Andre Mahé Emmanuel Rio Michel Chérel | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 5 | Nonlinear partial least squares显示文摘 | TAMHANE A C MAH R S H | 1997 | Computers Chemical Engineering1997，21，8： | 1 |
| 6 | A feasibility investigation on ultraflltration of palm oil and oleic acid removal from glycerin solutions: flux decline, fouling pattern, rejection and membrane characterizations显示文摘 | MAH S LEO C P WU T Y | 2012 | Journal of Membrane Science2012，389，： | 1 |
| 7 | Nonlinear partial least squares显示文摘 | Malthouse E C Tamhane A C Mah R S H | 1997 | Computers & Chemical Engineering1997，21，8： | 1 |
| 8 | gammaH2AX: a sensitive molecular marker of DNA damage and repair显示文摘 | Mah L J El-Osta A Karagiannis T C | 2010 | Leukemia2010，24，4： | 1 |
| 9 | Virus-based gene delivery systems 显示文摘 | Mah C Byrne BJ Flotte TR | 2002 | Clin Pharmacokinet2002，41，12： | 1 |
| 10 | Directed evolution of new glycosynthases from Agrobacterium β - glucosidase : a general screen to detect enzymes for oligosaccharide synthesis显示文摘 | Mayer C Jakeman D L Mah M | 2001 | Chemistry & Biology2001，8，5： | 1 |
| 11 | Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment显示文摘 | Jane W Susan C Claire MAH | 2008 | American Journal of Clln- ical Nutrition2008，87，2： | 1 |
| 12 | Human fibroblast growth factor receptor 1 is a co-receptor for infection by adenoassociated virus 2显示文摘 | Qing K Mah C Hansen J | 1999 | Nat Med1999，5，1： | 1 |
| 13 | Davis Oxaziridine-mediated Asymmetric Synthesisof Proton Pump Inhibitors Using DBU Salt ofProchiral Sulfide显示文摘 | MAH ALE R D RAJPUT M R MAIKAP G C etal | 2010 | Org Proc Res Dev2010，14，： | 1 |
| 14 | Outer membranepore protein prediction in mycobacteria using genomic com-parison显示文摘 | Mah N Perez-Iratxeta C Andrade-Navarro MA | 2010 | Microbiology2010，156，8： | 1 |
| 15 | Acridine orange-epifluorescence technique for counting bacteria in natural waters显示文摘 | Francisco D E Mah R A Rabin A C | 1973 | Transactions of the American Microscopical Society1973，92，3： | 1 |
| 16 | Process Trending with Piecewise Linear Smoothing 显示文摘 | Tamhane A C Tung S H Patel A H | | Computers Chem Engng0，19，2： | 1 |
| 17 | A compos- ite statistical test for detecting changes of steady state 显示文摘 | NARASIMHAN S MAH R S H TAMHANE A C | 1986 | Ameri- can Institute of Chemical Engineering Journal1986，32，9： | 1 |
| 18 | Differential recognition of ORF2 protein from type 1 and type 2 porcine circoviruses and identification of immunorelevant epitopes显示文摘 | Mahé D Blanchard P Truong C | 2000 | J Gen Virol2000，81，： | 1 |
| 19 | Can PET provide the 3D extent of tumor motion for individualized internal target volumes A phantom study of the limitations of CT and the promise of PET显示文摘 | Caldwell C B Mah K Skinner M | 2003 | Int J Radiat Oncol Biol Ph- ys2003，55，5： | 1 |
| 20 | A compos- ite statistical test for detecting changes of steady states 显示文摘 | NARASIMHAN S MAH R S H TAMHANE A C | 1986 | American Institute of Chemical Engineering Journal1986，32，9： | 1 |
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