|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Advances in regenerative therapies for spinal cord injury:a biomaterials approach显示文摘Spinal cord injury results in the permanent loss of function,causing enormous personal,social and economic problems.Even though neural regeneration has been proven to be a natural mechanism,central nervous system repair mechanisms are ineffective due to the imbalance of the inhibitory and excitatory factors implicated in neuroregeneration.Therefore,there is growing research interest on discovering a novel therapeutic strategy for effective spinal cord injury repair.To this direction,cell-based delivery strategies,biomolecule delivery strategies as well as scaffold-based therapeutic strategies have been developed with a tendency to seek for the answer to a combinatorial approach of all the above.Here we review the recent advances on regenerative/neural engineering therapies for spinal cord injury,aiming at providing an insight to the most promising repair strategies,in order to facilitate future research conduction. | Magdalini Tsintou Kyriakos Dalamagkas Alexander Marcus Seifalian | 2015 | Neural Regeneration Research2015，10，5： | 8 |
| 2 | Taking central nervous system regenerative therapies to the clinic: curing rodents versus nonhuman primates versus humans显示文摘The central nervous system is known to have limited regenerative capacity.Not only does this halt the human body’s reparative processes after central nervous system lesions,but it also impedes the establishment of effective and safe therapeutic options for such patients.Despite the high prevalence of stroke and spinal cord injury in the general population,these conditions remain incurable and place a heavy burden on patients’families and on society more broadly.Neuroregeneration and neural engineering are diverse biomedical fields that attempt reparative treatments,utilizing stem cells-based strategies,biologically active molecules,nanotechnology,exosomes and highly tunable biodegradable systems(e.g.,certain hydrogels).Although there are studies demonstrating promising preclinical results,safe clinical translation has not yet been accomplished.A key gap in clinical translation is the absence of an ideal animal or ex vivo model that can perfectly simulate the human microenvironment,and also correspond to all the complex pathophysiological and neuroanatomical factors that affect functional outcomes in humans after central nervous system injury.Such an ideal model does not currently exist,but it seems that the nonhuman primate model is uniquely qualified for this role,given its close resemblance to humans.This review considers some regenerative therapies for central nervous system repair that hold promise for future clinical translation.In addition,it attempts to uncover some of the main reasons why clinical translation might fail without the implementation of nonhuman primate models in the research pipeline. | Magdalini Tsintou Kyriakos Dalamagkas Nikos Makris | 2020 | Neural Regeneration Research2020，15，3： | 7 |
| 3 | Respiratory mechanics in brain injury: A review显示文摘Several clinical and experimental studies have shown that lung injury occurs shortly after brain damage. The responsible mechanisms involve neurogenic pulmonary edema, inflammation, the harmful action of neurotransmitters, or autonomic system dysfunction. Mechanical ventilation, an essential component of life support in brain-damaged patients(BD), may be an additional traumatic factor to the already injured or susceptible to injury lungs of these patients thus worsening lung injury, in case that non lung protective ventilator settings are applied. Measurement of respiratory mechanics in BD patients, as well as assessment of their evolution during mechanical ventilation, may lead to preclinical lung injury detection early enough, allowing thus the selection of the appropriate ventilator settings to avoid ventilatorinduced lung injury. The aim of this review is to explore the mechanical properties of the respiratory system in BD patients along with the underlying mechanisms, and to translate the evidence of animal and clinical studies into therapeutic implications regarding the mechanical ventilation of these critically ill patients. | Antonia Koutsoukou Maria Katsiari Stylianos E Orfanos Anastasia Kotanidou Maria Daganou Magdalini Kyriakopoulou Nikolaos G Koulouris Nikoletta Rovina | 2016 | World Journal of Critical Care Medicine2016，5，1： | 7 |
| 4 | Stem cells for spinal cord injuries bearing translational potential显示文摘Spinal cord injury(SCI) is a highly debilitating neurological disease, which still lacks effective treatment strategies, causing significant financial burden and distress to the affected families. Nevertheless, nanotechnology and regenerative medicine strategies holding promise for the development of novel therapies that would reach from bench to bedside to serve the SCI patients. There has already been significant progress in the field of cell-based therapies, with the clinical application for SCI, currently in phase II of the clinical trial. Stem cells(e.g., induced pluripotent stem cells, fetal stem cells, human embryonic stem cells, and olfactory ensheathing cells) are certainly not to be considered the panacea for neural repair but, especially when combined with rehabilitation or other combinatorial approaches using the help of nanotechnology, they seem to be the source of some of the most promising and clinical translatable cell-based therapies that could help solving impactful problems on neural repair. | Kyriakos Dalamagkas Magdalini Tsintou Alexander M.Seifalian | 2018 | Neural Regeneration Research2018，13，1： | 3 |
| 5 | Imaging of filtering blebs after implantation of the Ex-PRESS shunt with the use of the Visante optical coherence tomography显示文摘AIM: To analyze the features of the filtering blebs following implantation of the Ex-PRESS glaucoma device(model P-50) with the aid of the Visante anterior segment optical coherence tomography(AS-OCT)METHODS: Five patients with open angle glaucomas were included in the study. They all underwent implantation of the Ex-PRESS device under a scleral flap. The surgical procedure was augmented with the use of mitomycin C subconjunctivally. The filtering blebs were analyzed with the Visante AS-OCT with the scans taken along the axis of the implantation of the glaucoma device.RESULTS: All filtering blebs were graded as diffuse functioning. The morphological characteristics of the blebs were similar to those of the trabeculectomy.However the use of the Ex-PRESS implant tend to form a characteristic episcleral lake at the site of the plate of the implant. CONCLUSION: The use of the Ex-PRESS implant produces filtering blebs similar to those of the trabeculectomy with the formation of a characteristic episcleral lake at the site of the plate of the implant. | Aristeidis Konstantinidis Georgios D Panos Magdalini Triantafylla Georgios Labiris Efthimia Tsaragli Zisis Gatzioufas Vassilios Kozobolis | 2015 | International Journal of Ophthalmology(English edition)2015，8，3： | 2 |
| 6 | The use of hydrogel-delivered extracellular vesicles in recovery of motor function in stroke:a testable experimental hypothesis for clinical translation including behavioral and neuroimaging assessment approaches显示文摘Neural tissue engineering,nanotechnology and neuroregeneration are diverse biomedical disciplines that have been working together in recent decades to solve the complex problems linked to central nervous system(CNS)repair.It is known that the CNS demonstrates a very limited regenerative capacity because of a microenvironment that impedes effective regenerative processes,making development of CNS therapeutics challenging.Given the high prevalence of CNS conditions such as stroke that damage the brain and place a severe burden on afflicted individuals and on society,it is of utmost significance to explore the optimum methodologies for finding treatments that could be applied to humans for restoration of function to pre-injury levels.Extracellular vesicles(EVs),also known as exosomes,when derived from mesenchymal stem cells,are one of the most promising approaches that have been attempted thus far,as EVs deliver factors that stimulate recovery by acting at the nanoscale level on intercellular communication while avoiding the risks linked to stem cell transplantation.At the same time,advances in tissue engineering and regenerative medicine have offered the potential of using hydrogels as bio-scaffolds in order to provide the stroma required for neural repair to occur,as well as the release of biomolecules facilitating or inducing the reparative processes.This review introduces a novel experimental hypothesis regarding the benefits that could be offered if EVs were to be combined with biocompatible injectable hydrogels.The rationale behind this hypothesis is presented,analyzing how a hydrogel might prolong the retention of EVs and maximize the localized benefit to the brain.This sustained delivery of EVs would be coupled with essential guidance cues and structural support from the hydrogel until neural tissue remodeling and regeneration occur.Finally,the importance of including nonhuman primate models in the clinical translation pipeline,as well as the added benefit of multi-modal neuroimaging analysis to establish non-invasive,in vivo,quantifiable imagingbased biomarkers for CNS repair are discussed,aiming for more effective and safe clinical translation of such regenerative therapies to humans. | Magdalini Tsintou Kyriakos Dalamagkas Tara LMoore Yogesh Rathi Marek Kubicki Douglas LRosene Nikos Makris | 2021 | Neural Regeneration Research2021，16，4： | 2 |
| 7 | Marketing and promotion of e-books in academic libraries显示文摘 | Magdalini Vasileiou Jennifer Rowley | 2011 | Journal of Documentation2011，，4： | 1 |
| 8 | Photocatalytic and sonolytic oxidationof Acid Orange 7 in aqueous solution 显示文摘 | Theodora Velegraki Ioannis Poulios Magdalini Cha-ralababki | 2006 | Appl CatalB: Environ2006，62，： | 1 |
| 9 | The effeet of the method of drying on the eolorof dehydrated produets 显示文摘 | Magdalini K Krokida Zaeharias BMaroulis George D Saravaeos | 2001 | International Journal of Food Science and Technology2001，36，： | 1 |
| 10 | Photocatalytic and sonolytic oxidation of acid orange 7 in aqueous solution 显示文摘 | Theodore Velegraki Ioannis Poulios Magdalini Charalabaki | 2006 | Applied Catalysis B: Environmental2006，62，1： | 1 |
| 11 | Web mining for web personalization 显示文摘 | Magdalini Eirinaki Michalis Vazirgannis | 2003 | ACM Transactions on Intemet Technology2003，3，1： | 1 |
| 12 | Effects of drying and extraction methods on the quality and antioxidant activity of sea buckthorn (Hippophae rhamnoides) berries and leaves显示文摘 | KONSTANTINA K ATHINA P MAGDALINI K | 2013 | Drying Technology2013，31，9： | 1 |
| 13 | The influence of freeze drying conditions on micro- structural changes of food products 显示文摘 | Vasiliki P Oikonomopoulou Magdalini K Krokida Vaios T Karathanos | 2011 | Procedia Food Science2011，，1： | 1 |
| 14 | Effect of a polyphenol - rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activity 显示文摘 | Magdalini A Papandreoua Andriana Dimakopoulou Zacharoula I Linardaki | 2009 | Behavioural Brain Research2009，，： | 1 |
| 15 | Photocatalytic and sonolytic oxidation of acid orange 7 in aqueous solution 显示文摘 | Theodora Velegraki Ioannis Poulios Magdalini Charalabaki | 2006 | Applied Catalysis B: Environmental2006，62，： | 1 |
| 16 | Photocatalytic and sonolytie oxidation of acid orange 7 in aqueous solution 显示文摘 | Theodora Velegraki Ioannis Poulios Magdalini Charalabaki | 2006 | Applied Catalysis B : Environmental2006，62，1： | 1 |
| 17 | Acute ischemic colitis during scuba diving: Report of a unique case显示文摘The presentation of clinical symptoms due to decompression during diving, varies significantly, as mainly minor disturbances for the gastrointestinal tract in particular have been reported. The following case debates whether diving can cause severe symptoms from the gastrointestinal system. We describe a clinical case of ischemic colitis presented in a 27-year-old male, who manifested abdominal pain while in the process of scuba diving 20 meters undersea, followed by bloody diarrhoea as soon as he ascended to sea level. Taking into account his past medical history, the thorough, impeccable clinical and laboratory examinations and presence of no other factors predisposing to ischemia of the colon, we assume that a possible relationship between diving conditions and the pathogenesis of ischemic colitis may exist. This unusual case might represent a hematologic manifestation of decompression sickness, due to increased coagulability and/or transient air emboli, occurring during a routine scuba diving ascent to sea level. | Konstantinos Goumas Androniki Poulou Ioannis Tyrmpas Dimitrios Dandakis Stavros Bartzokis Magdalini Tsamouri Kalipso Barbati Dimitrios Soutos | 2008 | World Journal of Gastroenterology2008，14，20： | 1 |
| 18 | The effect of the method of drying on the colour of dehydrated products显示文摘 | Magdalini K.Krokida Zacharias B.Maroulis | 2008 | International Journal of Food Science & Technology2008，，1： | 1 |
| 19 | Effect of a polyphenol-rich wild blueberry extract on cogn- itive performance of mice, brain antioxidant mar- kers and acetylcholinesterase activity 显示文摘 | Magdalini A Papandreou Andriana Dimakopo- ulou Zacharoula I Linardaki | 2009 | Beha- vio ural Brain Research2009，198，： | 1 |
| 20 | Functional properties of corn and corn-lentil extrudates显示文摘 | ANDRIANA LAZOU MAGDALINI KROKIDA | 2010 | Food Research International2010，，43： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员