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| 1 | 血管内皮生长因子基因修饰对裸鼠移植皮肤替代物的影响显示文摘目的 了解血管内皮生长因子(VEGF)基因修饰对皮肤替代物移植后的影响。 方法将72只裸鼠分为实验组,以含VEGF目的基因的腺病毒载体转染人成纤维细胞(Fb),将其接种于In tegra人工皮后移植于裸鼠创面;绿色荧光蛋白(GFP)对照组,用于转染Fb的腺病毒载体不含VEGF目的基因,但含与实验组相同的指示标记物GFP基因片段;Fb对照组,接种于Integra人工皮的Fb未行基因转染,其他处理与前两组完全相同;无细胞对照组,所移植的Integra人工皮未接种Fb,每组18只。评估实验组及各对照组移植物的成活情况、血管化过程及组织学变化。 结果 实验组移植术后移植皮片新生血管形成情况明显优于各对照组(P<0. 05),术后早期移植皮片与创面贴附较牢固,分离时易引起出血。实验组移植皮片成活率(100. 0% )显著高于GFP、Fb、无细胞对照组(分别为83. 3%、75. 0%、77 8%, P<0. 01 ),而感染率低于各对照组(P<0. 05 ). 结论 基因修饰所致VEGF高表达明显促进了移植皮肤替代物的血管化过程,提高了移植物成活率。 | 谢卫国 Werner Lindenmaier Stefan Gryzybowski Hans-Gunther Machens | 2005 | 中华烧伤杂志2005，21，3： | 9 |
| 2 | 光学相干断层成像技术诊断深Ⅱ度烧伤创面实验研究显示文摘目的 评估光学相干断层成像技术(OCT)在诊断烧伤创面深度方面的应用价值.方法 应用自制的小鼠蒸气烫伤装置,制作Skh-1小鼠深Ⅱ度烫伤模型,分别于伤后3 h、3 d和8 d以OCT扫描创面行动态检测,同步采集创面组织行组织病理学检查;同时扫描小鼠正常部位皮肤并行组织病理学检查. 结果蒸气烫伤小鼠皮肤真皮胶原降解,与其正常部位皮肤相比,在OCT扫描检测中表现为双折射光信号的丢失或减弱,其变化强度与创面病变过程相关,且与组织病理学切片结果一致. 结论 OCT作为无创的创面检测技术,可用于烧伤创面动态检测. | 刘淑华 谢卫国 Mathias Kremer Hans Guenther Machens Eva Maria Lankenau Gereon Huettmann | 2010 | 中华烧伤杂志2010，26，4： | 2 |
| 3 | The impact of ipsilateral testicular atrophy on semen quality and sperm DNA fragmentation response to varicocele repair显示文摘Varicoceles adversely impact semen quality and sperm DNA fragmentation,which typically improve with surgical repair.Some men with varicoceles have ipsilateral testicular atrophy due to damage from the varicocele.This study assessed semen quality and the sperm DNA fragmentation index(DFI)response to varicocele repair in men with ipsilateral testicular atrophy(TA)versus men with no testicular atrophy(NTA).Semen parameter values and DFI in both groups were compared preoperatively and postoperatively.The Mann-Whitney U test and the Wilcoxon signed-rank test were used where appropriate.There were 20 men in the TA group and 121 men in the NTA group with no difference in age,varicocele grade,or preoperative semen parameter values between the two groups.The NTA group had a higher preoperative DFI than the TA group.Both groups showed improvement in semen quality postoperatively,only the TA group showed a significant improvement in DFI,whereas the NTA group showed significant improvements in several parameter values and DFI.The change from preoperative to postoperative parameter values when comparing the two groups revealed a difference in total sperm motile count and DFI,with a larger mean improvement in the NTA group than in the TA group.Both TA and NTA groups showed improved semen quality and DFI after varicocele repair,but the NTA group had more improvement than the TA group.However,only total motile count(TMC)and DFI had a significantly greater mean change in preoperative to postoperative response in the NTA group than in the TA group. | Parviz K Kavoussi Natasha Abdullah Melissa S Gilkey Caitlin Hunn G Luke Machen Shu-Hung Chen Keikhosrow M Kavoussi Amy Esqueda J David Wininger Shahryar K Kavoussi | 2021 | Asian Journal of Andrology2021，23，2： | 2 |
| 4 | Heightened gingival inflammation and attachment loss in type 2 diabetics with hyperlipidemia显示文摘 | Cutler CW Machen RL Jotwani R | 1999 | J Periodontol1999，70，11： | 1 |
| 5 | Minimally invasive compared with conventional thyroidectomy for nodular goitre显示文摘 | Dralle H Machens A Thanh PN | 2014 | Best Pract Res Clin Endocrinol Metab2014，28，4： | 1 |
| 6 | Cytokeratin-negative desmoplastic small roud cell tumor: a report of two cases emphasizing the utility of reverse transcriptase-polymerase chain reaction显示文摘 | Trupiano JK Machen SK Barr FG | 1999 | Mod Pathol1999，12，9： | 1 |
| 7 | Surgical approaches in thyroid cancer and lymph-node metastase 显示文摘 | Dralle H Machens A | 2008 | Best Pract Res Clin Endocrinol Metab2008，22，6： | 1 |
| 8 | Thyroid carcinoma invading the cervicovisceral axis:routes of invasion and clinical implications显示文摘 | MACHENS A HINZE R LAUTENSCHLAGER C | 2001 | Surgery2001，129，1： | 1 |
| 9 | Interleukin-7 is a survivalfactor for CD4 + CD25 + T-cells and is expressed by diabetes-suppressive dendritic cells 显示文摘 | Hamaha J Machen J Wright M | 2006 | Diabetes2006，55，1： | 1 |
| 10 | Abnormal carcinoembryonic antigen levels and medullary thyroid cancer progression: a multivariate analysis显示文摘 | Machens A Ukkat J Hauptmann S | 2007 | Arch Surg2007，142，3： | 1 |
| 11 | The prognostic value of primary tumor size in papillary and follicular thyroid carcinoma 显示文摘 | Machens A Holzhausen H J Dralle H | 2005 | Cancer2005，103，： | 1 |
| 12 | Long-term outcome and quality of life after thymectomy for myasthenia gravis显示文摘 | Busch C Machens A Pichlmeier U | 1996 | Ann Surg1996，224，2： | 1 |
| 13 | Parental acceptance of pediatric dentistry behavior management techniques 显示文摘 | Murphy MG Fields HW Machen JB | 1984 | Pediatr Dent1984，6，4： | 1 |
| 14 | Multivariate analysis of risk factors for postoperative complications in benign goiter surgery: prospective multicenter study in Germany显示文摘 | Thomusch O Machens A Sekulla C | 2000 | World J Surg2000，24，4： | 1 |
| 15 | Early malignant progression of hereditary medullary thyroid cancer显示文摘 | Niccoli-Sire P Hoegel J | 2003 | N Engl J Med2003，349，16： | 1 |
| 16 | Skip metastasis in thyroid cancer leaping the central lymph node compartment显示文摘 | Machens A Holzhausen HJ Dralle H | 2004 | Arch Surg2004，139，： | 1 |
| 17 | Procalcitonin as a maker for the early diagnosis of sever infection after thermal injury 显示文摘 | SAACHSE C MACHENS H G FELMERER G | 1999 | Burn Care Rehabil1999，20，： | 1 |
| 18 | Effect of intruenous im-muinoglobulin G on the TNF alpha-medicated hepatilc microvascalarinflammatory respones显示文摘 | Ito Y Lukita-Atmagja W Machen NW | 1999 | Shock1999，11，2： | 1 |
| 19 | Breach of the thyroid capsule and lymph node capsule in node-positive papillary and medullary thyroid cancer: Dif- ferent biology显示文摘 | Machens A Dralle H | 2015 | Eur J Surg Oncol2015，41，6： | 1 |
| 20 | Pattern of nodal metas- tasis for primary and reoperative thyroid cancer显示文摘 | Machens A Hinze R Thomusch O | 2002 | World J Stag2002，26，1： | 1 |
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