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| 1 | Reduced striatal volumes in Parkinson’s disease:a magnetic resonance imaging study显示文摘Background:The presence and extent of structural changes in the brain as a consequence of Parkinson’s disease(PD)is still poorly understood.Methods:High-resolution 3-tesla T1-weighted structural magnetic resonance images in sixty-five PD and 27 age-matched healthy control participants were examined.Putamen,caudate,and intracranial volumes were manually traced in the axial plane of 3D reconstructed images.Striatal nuclei volumes were normalized to intracranial volume for statistical comparison.Disease status was assessed using the Unified Parkinson’s Disease Rating Scale and Hoehn and Yahr scale.Cognitive status was assessed using global status tests and detailed neuropsychological testing.Results:Both caudate and putamen volumes were smaller in PD brains compared to controls after adjusting for age and gender.Caudate volumes were reduced by 11%(p=0.001)and putamen volumes by 8.1%(p=0.025).PD striatal volumes were not found to be significantly correlated with cognitive or motor decline.Conclusion:Small,but significant reductions in the volume of both the caudate and putamen occur in PD brains.These reductions are independent of the effects of age and gender,however the relation of these reductions to the functional loss of dopamine,which is characteristic of PD,remains unclear. | Toni L Pitcher Tracy R Melzer Michael R MacAskill Charlotte F Graham Leslie Livingston Ross J Keenan Richard Watts John C Dalrymple-Alford Tim J Anderson | 2012 | Translational Neurodegeneration2012，1，1： | 2 |
| 2 | MRI findings are more common in selected patients with acute low back pain than controls显示文摘 | Hancock M Maher C Macaskil P | | 0，，02： | 1 |
| 3 | The MoCA: well- suited screen for cognitive impairment in Parkinson disease显示文摘 | Dalrymple - Alford J C MacAskill M R Nakas C T | 2010 | Neurology2010，75，19： | 1 |
| 4 | Serum levels of phosphorus, parathyroid hormone, and calcium and risks of death and cardiovascular disease in individuals with chronic kidney disease: A systematic review and meta- analysis 显示文摘 | Palmer S C Hayen A Macaskill P | 2011 | JAMA2011，305，11： | 1 |
| 5 | Serum Levels of phos- phorus, Parathyroid hormone,and calcium and risks of death and cardiovascular disease in individuals with chronic Kidney disease: a systematic review and meta-analysis显示文摘 | Palmer S C Hayen A Macaskill P | 2011 | JAMA2011，305，11： | 1 |
| 6 | Production-time balances for mixed-model lines显示文摘 | Macaskill J L C | 1972 | Management Science1972，19，： | 1 |
| 7 | Serum levels of phospho-rus,parathyroid hormone,and calcium and risks of death and car-diovascular disease in individuals with chronic kidney disease:a systematic review and meta-analysis显示文摘 | Palmer S C Hayen A Macaskill P | 2011 | JAMA2011，305，11： | 1 |
| 8 | Production Line Balances for Mixed Model Lines显示文摘 | Macaskill J L C | 1972 | Management Science1972，19，4： | 1 |
| 9 | Characterizing mild cognitive impairment in Parkin- son's disease显示文摘 | Dalrymple-AlfordJ C Livingston L MacAskill M R | 2011 | Mov Disord2011，26，4： | 1 |
| 10 | Gcn4 co-ordinates morphogenetic and metabolic responses to amino acid starvation in Candida albicans 显示文摘 | Tripathi G Wiltshire C Macaskill S Tournu H Budge S Brown ALIp | 2002 | EMBO J2002，21，20： | 1 |
| 11 | Serum levels of phospho- rus,parathyroid hormone, and calcium and risks of death and cardiovascular disease in individuals with chronic kidney disease: a systematic review and meta-analysis显示文摘 | Palmer S C Hayen A Macaskill P | 2011 | JAMA2011，305，11： | 1 |
| 12 | Serum levels of phosphorus,parathyroid hormone,and calcium and risks of death and cardiovascular disease in individu-als with chronic kidney disease a systematic review and meta-analysis显示文摘 | Palmer S C Hayen A Macaskill P | 2011 | JAMA:the journal of the Ameri-can Medical Association2011，305，： | 1 |
| 13 | Serum levels of phospho-rus,parath-yroid hormone,and calcium and risks of death and cardiovas cular disease in individuals with chronic kidney dis-ease:a systematic review and meta-analysis显示文摘 | Palmer S C Hayen A Macaskil P | | 0，，11： | 1 |
| 14 | Serum levels of phosphorus, parathyroid hormone, and calcium and risks of death and cardiovascular disease in individuals with chronic kidney di- sease: a systematic review and meta - analysis显示文摘 | PALMER S C HAYEN A MACASKILL P | 2011 | JAMA2011，305，11： | 1 |
| 15 | Serum levels ofphosphorus, parathyroid hormone,and calcium and risks of deathand cardiovascular disease in individuals with chronic kidney di-sease :a systematic review and meta - analysis 显示文摘 | PALMER S C HA YEN A MACASKILL P | 2011 | JAMA2011，14，11： | 1 |
| 16 | The MoCA: well-suited screen for cognitive impairment in Parkinson disease 显示文摘 | Dalrymple-Alford J C MacAskill M R Nakas C T ei al | 2010 | Neurology2010，75，19： | 1 |
| 17 | Serum levels of phosphorus, parathyroid hormone, and calcium and risks of death and cardiovascular disease in individuals with chronic kidney disease; a systematic review and meta- analysis显示文摘 | Palmer S C Hayen A Macaskill P | 2011 | JAMA2011，305，11： | 1 |
| 18 | The embedded finite difference method for the Poisson equation in a domain with an irregular boundary and Dirichlet boundary conditions 显示文摘 | Jomaa Z Macaskill C | 2005 | J Comput Phys2005，202，2： | 1 |
| 19 | Computer simulation of two-dimensional random wave propagation显示文摘 | Macaskill C Ewart T E | 1984 | IMA J Appl Math1984，33，1： | 1 |
| 20 | Meta-analysis: vitamin D compounds in chronic kidney disease显示文摘 | PALME S C MCGREGOR D O MACASKILL P | 2007 | Ann Intern Med2007，147，12： | 1 |
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