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| 1 | 高纤维膳食和补充乙酸盐改变肠道菌群,预防醋酸脱氧皮质酮-盐型高血压小鼠高血压和心力衰竭的发展显示文摘水果和蔬菜的膳食摄入与高血压的发生率较低有关,但所涉及的机制尚未阐明。该研究评估了高纤维膳食和短链脂肪酸(short-chain fatty acid,SCFA)(乙酸盐)对肠道微生物群和预防心血管病的影响。方法:用盐皮质激素诱发小鼠高血压模型,观测正常喂食组、高纤维喂食组和补充乙酸盐组的肠道微生物、心脏结构/功能和血压水平。 | 刘莉 叶鹏 Marques FZ Nelson EM Chu PY Horlock D Fiedler A Ziemann M Tan JK Kuruppu S Rajapakse NW El-Osta A Mackay CR Kaye DM | 2016 | 中华高血压杂志2016，24，12： | 8 |
| 2 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 3 | The Changing Cold Regions Network:Observation,diagnosis and prediction of environmental change in the Saskatchewan and Mackenzie River Basins,Canada显示文摘Climate change is causing rapid and severe changes to many Earth systems and processes,with widespread cryospheric,ecological,and hydrological impacts globally,and especially in high northern latitudes.This is of major societal concern and there is an urgent need for improved understanding and predictive tools for environmental management.The Changing Cold Regions Network(CCRN)is a Canadian research consortium with a focus to integrate existing and new experimental data with modelling and remote sensing products to understand,diagnose,and predict changing land,water,and climate,and their interactions and feedbacks over the geographic domain of the Mackenzie and Saskatchewan River Basins in Canada.The network operates a set of 14 unique and focused Water,Ecosystem,Cryosphere and Climate(WECC)observatories within this region,which provide opportunities to observe and understand processes and their interaction,as well as develop and test numerical simulation models,and provide validation data for remote sensing products.This paper describes this network and its observational,experimental,and modelling programme.An overview of many of the recent Earth system changes observed across the study region is provided,and some local insights from WECC observatories that may partly explain regional patterns and trends are described.Several of the model products being developed are discussed,and linkages with the local to international user community are reviewed—In particular,the use of WECC data towards model and remote sensing product calibration and validation is highlighted.Some future activities and prospects for the network are also presented at the end of the paper. | Chris M DEBEER Howard S WHEATER William L QUINTON Sean K CAREY Ronald E STEWART Murray D MACKAY Philip MARSH | 2015 | Science China Earth Sciences2015，58，1： | 5 |
| 4 | Transcribed her-eroplasmic repeated sequences in the porcine mitochondrial DNA D-loop region显示文摘 | Ghlvlzzani SC Mackay SL Madsen C S | 1993 | J Mol Evol1993，37，1： | 1 |
| 5 | Multilineage paential of adult human mesenchymal stem cells 显示文摘 | PITFENGER M F MACKAY A M BECK S C | 1999 | Science1999，284，5411： | 1 |
| 6 | Imaging and velocity estimation with depth-focusing analysis显示文摘 | MacKay S Abma R | 1992 | Geophysics1992，57，12： | 1 |
| 7 | Guideline to reference gene selection for quantitative real-time PCR显示文摘 | Radonic A Thulke S Mackay 1M | 2004 | Biochem Biophys Res Commun2004，313，4： | 1 |
| 8 | Droplet size distribu- tions in chemical dispersion of oil spills:towards a mathe- matical model显示文摘 | Daling P S Mackay D Mackay N | 1990 | Oil and Chemical Pollution1990，7，3： | 1 |
| 9 | Multilineage potential of adult human mesenchymal stem cells显示文摘 | Pittenger M F Mackay A M Beck S C | | 0，，5411： | 1 |
| 10 | Blockade of programmed death ligand 1 enhances the therapeutic efficacy of combination immunotherapy against melanoma显示文摘 | Pilon-Thomas S Mackay A Vohra N | 2010 | J Immunol2010，184，7： | 1 |
| 11 | Genetic control of so- matic embryogenesis initiation in loblolly pine and implications for breeding显示文摘 | MacKay J J Becwar M R Park Y S | 2006 | Tree Genet Genomes2006，2，1： | 1 |
| 12 | Human interleukin-I0 suppresses production of inflammatory mediators by LPS-stimulated equine peritoneal macrophages显示文摘 | Hawkins D L Mackay R J Mackay S L | 1998 | Veterinary Immunology & Immunopathology1998，66，1： | 1 |
| 13 | Effects of distribution-based pa- rameter aggregation on a spatially distributed agricultural nonpoint source pollution model 显示文摘 | Chen E Mackay D S | 2004 | Journal of Hydrolo- gy2004，295，1： | 1 |
| 14 | Phase II study of oral ridaforolimus in patients with metastatic and/or lo- cally advanced recurrent endometrial cancer: NCIC CTG 1ND 192显示文摘 | Mackay H Welch S Tsao M S | 2011 | J Clin Oncol2011，29，： | 1 |
| 15 | Comparison of constructions of irregular Gallager codes 显示文摘 | MacKay D J C Wilson S T Matthew C D | 1999 | IEEE Trans Commun1999，47，10： | 1 |
| 16 | Cocaine abusers have reduced auditory P50 amplitude and suppression compared to both normal controls and alcoholics显示文摘 | Biggins C MacKay S | 1996 | Biol Psychiatry1996，39，： | 1 |
| 17 | Guideline to reference gene selection for quantitative real-time PCR 显示文摘 | Radonic A Thulke S Mackay IM | 2004 | Siochem Siophys Res Commun2004，313，4： | 1 |
| 18 | The natural history of ankylosing spondylitis as defined by radiological progression 显示文摘 | Brophy S Mackay K A1 Saidi A | 2002 | J Rheumatol2002，29，： | 1 |
| 19 | Impacts of input parameter spa-tial aggregation on an agricultural nonpoint source pollutionmodel显示文摘 | Fitzhugh T W Mackay D S | 2000 | Journal of Hydrology2000，236，： | 1 |
| 20 | Multilineage potential of adult human mesenchymal stem cells显示文摘 | Pittenger M F Mackay A M Beck S C | 1999 | Science1999，284，： | 1 |
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