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| 1 | Developmental Lead Exposure Alters the Distribution of Protein Kinase C Activity in the Rat Hippocampus显示文摘Chronic low-level lead (Pb) exposure in children is known to cause a deficit in learning and memory. In vitro studies have demonstrated that Pb altered protein kinase C (PKC) activityt Especially, hippocampal PKC has been correlated with performance in several learning tasks. The effects of Pb exposure on hippocampal PKC were investigated during development at various postnatal ages: postnatal day (PN) 7, 14, 28, and 56. Two-tenth % Pb acetate was administered to pregnant and lactating dams and then administered to weanling rats in drinking water. PKC activity was measured in both membrane and cytosolic fractions from the hippocampi of the controls and Pb-exposed animals. Pb-induced increase in PKC activity in the cytosolic fraction was obsereved in the PN56 rats. In contrast, PKC activity was decreased by Pb at PN7 in the membrane fraction. Furthermore, a significant decrease in the ratio of membrane to cytosolic PKC activity which is representative of PKC distribution was observed in the PN28 and PN56 Pb-exposed rats relative to the same-age controls. This study indicates that chronic Pb exposure during development influences hippocampal PKC activity and distribution. These changes may be involved in the subclinical neurotoxicity of chronic Pb exposure in young children. | HWEI-HSIEN CHEN TANGENG MA ARTHUR S. HUME AND ING K. HO(Deportment of Pharmacology and Toxicology, University ofMississippi Medical Center, 2500 North State Street,Jackson, MS 39216, USA) | 1998 | Biomedical and Environmental Sciences1998，11，1： | 7 |
| 2 | Molecular phylogeny of all human enterovirus serotypes based on comparison of sequences at the 5' end of the region encoding VP2显示文摘 | Maher K Pallansch MA | 1998 | Virus Res1998，58，12： | 1 |
| 3 | Evaluation of the diagnosticvalue of measuring IgG,IgM and IgA antibodies to the recombinant16-kilodalton antigen of mycobacterium tuberculosis in childhood tu-berculosis显示文摘 | Imaz MS Comini MA Zerbini E | 2001 | Int J Tuberc Lung Dis2001，5，11： | 1 |
| 4 | patient with multiple sclerosis显示文摘 | Valsasina P Rocca MA Agosta F Mean diffusivity and frac- tional anisotropy histograms of the cervical cord in MS patients | 2005 | Neuroimage2005，26，3： | 1 |
| 5 | The role of complement, C5a and its receptors in sepsis and multiorgan dysfunction syndrome显示文摘 | Flierl MA Schreiber H Huber-Lang MS | 2006 | J Invest Surg2006，19，4： | 1 |
| 6 | A conformationnumber to quantify the degree of conformality in brachytherapy and extemal beam irradiation:Application to the prostate 显示文摘 | Van'Riet MS Mak AC Moeland MA | 1997 | Int J Ra- diat Oncol Biol Phys1997，37，3： | 1 |
| 7 | Portal venous and segmental anatomy of the right hemiliver: observation based on three - dimensional spiral CT renderings 显示文摘 | Van Leeuwen MS Norrdzij J Fernandez MA | 1994 | AJR1994，163，6： | 1 |
| 8 | HeartWare miniature axial-flow ventrieular assist device-design and initial feasibility test显示文摘 | Slaughter MS Sobieski MA Tamez D | 2009 | Tex Heart Inst J2009，36，1： | 1 |
| 9 | Tricks of the trade for the appropriate management of newly diagnosed acute promyelocytic leukemia显示文摘 | Sanz MA Tallman MS Lo-Coco F | 2005 | Blood2005，105，： | 1 |
| 10 | The orthopaedic implications of diphosphonate therapy 显示文摘 | Weaver M J Miller MA Vrahas MS | 2010 | J Am Acad Orthop Surg2010，18，6： | 1 |
| 11 | The Risk Factors of External Ventricular Drainage-Related Infection at Hospital Kuala Lumpur: An Observational Study显示文摘 | Omarl MA Mohd Haspani MS | 2010 | Malays J Med Sci2010，17，3： | 1 |
| 12 | Effects of combining electrical stimulation with BDNF gene transfer on the regeneration of crushed rat sciatic nerve显示文摘 | Alrashdan MS Sung MA Kwon YK | | 0，，： | 1 |
| 13 | Molecular events in the cardiomyopathy of sepsis显示文摘 | Flied MA Rittirsch D Huber Lang MS | 2008 | Mol Med2008，14，： | 1 |
| 14 | Tissuefactor dependent liver injury causes release of retinoidreceptors (RXR-α and RAR-α) as lipid droplets 显示文摘 | Abdel-Bakky MS Hammad MA Walker LA | 2011 | Biochem Biophys Res Commun2011，410，1： | 1 |
| 15 | Attributes of Stachybotrys chartarum and its association with human disease 显示文摘 | Hossian MA Ahmed MS Ghannoum MA | 2004 | JAllergy Clin Immunol2004，113，2： | 1 |
| 16 | Comparison of automated and manual nucleic acid extraction methods for detection of enterovirus RNA显示文摘 | Knepp JH Geahr MA Forman MS | 2003 | J Clin Microbiol2003，41，8： | 1 |
| 17 | Chemical and biological investigations of Dillenia indica Linn显示文摘 | Parvin MN Rahman MS Islam MS Rashid MA | 2009 | Bangladesh J Pharmacol2009，4，2： | 1 |
| 18 | p53 tumor suppressor gene mutations predict decreased survival of patients with sporadic colorectal carcinoma 显示文摘 | Kahlenberg MS Stober DL Rodriguez-Bigas MA | 2000 | Cancer2000，88，8： | 1 |
| 19 | Physical characterization and dissolution properties of Ibuprofen:Eudragit coprecipitates显示文摘 | Kislalioglu MS Khan MA Blount C | 1991 | J Pharm Sci1991，80，8： | 1 |
| 20 | 2001 consensus guidelines for the management of women with cervical intraepithelial neoplasia显示文摘 | Hoffman MS Martino MA | 2004 | Am J Obstet Gynecol2004，191，3： | 1 |
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