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| 1 | Insights into the role of gut microbiota in obesity: pathogenesis, mechanisms, and therapeutic perspectives显示文摘 | Lijuan Sun Lanjing Ma Yubo Ma Faming Zhang Changhai Zhao Yongzhan Nie | 2018 | Protein & Cell2018，9，5： | 29 |
| 2 | A transmission electron microscopy study on the crystallization of amorphous Ni-P electroless deposited coatings显示文摘 | Ma Faming Luo Shoufu Li Pengxing | 1988 | Thin Solid Films1988，166，： | 1 |
| 3 | Seven facts and five initiatives for gut microbiome research显示文摘The gut microbiome has attracted increasing attention over the past 15 years.Along with the fast-growing body of research literature and media reports,the public's opinions on the gut microbiome have begun to appear polarized.Some believe that the gut microbiome is at the core of human health and is related to every single disease.To the opposite,some people question the scientific basis of gut microbiome studies and criticize that many of them are farfetched;there is even a joke spreading in the biomedical research field—'keeping gut microbiome in mind,no mechanism is hard to find'. | Danyi Li Chunhui Gao Faming Zhang Ruifu Yang Canhui Lan Yonghui Ma Jun Wang | 2020 | Protein & Cell2020，11，6： | 1 |
| 4 | Gut microbisal methionine impacts circadian clock gene expression and reactive oxygen species level in host gastrointestinal tract显示文摘Dear Editor,Circadian rhythms are the periodic turmover of biological behaviors and physiological functions of many organisms(Allada and Bass,2021).In mammals,circadian rhythms are maintained by the clock system,involving central clock in suprachiasmatic nucleus and peripheral clock in organs like intestine;and at cellular level a cell-autonomous transcriptional and translational feedback loop involving clock genes like BMAL1(brain and muscle ARNT-Like 1,also known as ARNTL),CLOCK(clock circadian regulator),PER1/2/3(period circadian regulator 1/2/3)and CRY1/2(cryptochrome circadian regulator 1/2)(Allada and Bass,2021). | Xiaolin Liu Yue Ma Ying Yu Wenhui Zhang ingjing Shi Xuan Zhang Min Dai Yuhan Wang Hao Zhang Jiahe Zhang Jianghua Shen Faming Zhang Moshi Song Jun Wang | 2023 | Protein & Cell2023，14，4： | 1 |
| 5 | Reconstruction and Dynamics of the Human Intestinal Microbiome Observed In Situ显示文摘The human gut microbiome has primarily been studied through the use of fecal samples,a practice that has generated vital knowledge on the composition and functional capacities of gastrointestinal microbial communities.However,this reliance on fecal materials limits the investigation of microbial dynamics in other locations along the gastrointestinal tract(in situ),and the infrequent availability of fecal samples prevents analysis at finer temporal scales(e.g.,hours).In our study,we utilized colonic transendoscopic enteral tubing,a technology originally developed for fecal microbiota transplantation,to sample the ileocecal microbiome twice daily;metagenomic and metatranscriptomic analyses were then conducted on these samples.A total of 43 ileocecal and 28 urine and fecal samples were collected from five healthy volunteers.The ileocecal and fecal microbiomes,as profiled in the five volunteers,were found to be similar in metagenomic profiling,yet their active genes(metatranscriptome)were found to be highly distinct.Both microbiomes were perturbed after laxative exposure;over time,they exhibited reduced dissimilarity to their pre-treatment state,thereby demonstrating resilience as an innate property of the gut microbiome,although they did not fully recover within our observation time window.Sampling of the ileocecal microbiome during the day and at night revealed the existence of diurnal rhythms in a series of bacterial species and functional pathways,particularly those related to short-chain fatty acid production,such as Propionibacterium acnes and coenzyme A biosynthesis Ⅱ.Autocorrelation analysis and fluctuations decomposition further indicated the significant periodicity of the diurnal oscillations.Metabolomic profiling in the fecal and urine samples mirrored the perturbance and recovery in the gut microbiome,indicating the crucial contribution of the gut microbiome to many key metabolites involved in host health.This study provides novel insights into the human gut microbiome and its inner resilience and diurnal rhythms,as well as the potential consequences of these to the host. | Xiaolin Liu Min Dai Yue Ma Na Zhao Ziyu Wang Ying Yu Yakun Xu Huijie Zhang Liyuan Xiang He Tian Guanghou Shui Faming Zhang Jun Wang | 2022 | Engineering2022，8，8： | 0 |
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