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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | Market Orientation and Performance: Modelling a Neural Network 显示文摘 | Silva M Moutinho L Coelho A Marques A | 2009 | European Journal of Marketing2009，43，3： | 1 |
| 3 | Relocation of a Ca2 + -dependent protein kinase activity during pollen tube reorientation显示文摘 | Moutinho A Trewavas A J Malho R | 1998 | Plant Cell1998，10，： | 1 |
| 4 | Hover control of an UAV with backstepping design including input saturations显示文摘 | Azinheira J R Moutinho A | 2008 | IEEE Trans on Control System Technologe2008，16，3： | 1 |
| 5 | Attitude estimation in SO(3):A comparative UAV case study显示文摘 | Moutinho A Figueir?a M Azinheira J R | 2015 | Journal of Intelligent&Robotic Systems2015，80，3： | 1 |
| 6 | A backstepping controller for path-tracking of an underactuated autonomous airship显示文摘 | Azinheira J R Moutinho A Paiva E C | 2009 | Int J Robust and Nonlinear Control2009，19，4： | 1 |
| 7 | Abnormal uterine bleeding as a presenting symptom is related to multiple uterine leiomyoma : an ultrasound - based study 显示文摘 | FONSECA MOUTINHO J A BARBOSA L S TORRES D G | 2013 | Int J Womens Health2013，18，5： | 1 |
| 8 | Dynamic epigenetic reg- ulation of the micmRNA-200 family mediates epithelial and mes- enchymal transitions in human tumorigenesis 显示文摘 | Davalos V Moutinho C Villanueva A | 2012 | Oncogene2012，31，16： | 1 |
| 9 | Signalling pathways in pollen tube growth and reorientation显示文摘 | Malho R Camacho L Moutinho A | 2000 | Ann Bot2000，85，： | 1 |
| 10 | Promoter CpG island hypermethylation of the DNA repair enzyme MGMT predicts clinical response to dacarbazine in a phase I1 study for metastatic colorectal cancer 显示文摘 | Amatu A Sartore-Bianchi A Moutinho C | 2013 | Clin Cancer Res2013，19，8： | 1 |
| 11 | Modeling Bank Customer Satisfaction Through Mediation of Attitudes Towards Human and Automated Banking显示文摘 | MOUTINHO L SMITH A | 2000 | International Journal of Bank Marketing2000，18，3： | 1 |
| 12 | Appli- cation of FT-IR-ATR Spectroscopy to Evaluate the Penetration of Sur- face Sizing Agents into the Paper Structure 显示文摘 | Paulo J Ferreira lose A Gamelas Isabel M Moutinho | 2009 | Industrial and Engi- neering Chemistry Research2009，48，8： | 1 |
| 13 | The association between metabolic syndrome and its components and heart failure in patients referred to a primary care facility显示文摘 | COELHO F A MOUTINHO M A DE MIRANDA V A | 2007 | Alq Bras Cardiol2007，89，1： | 1 |
| 14 | Application of FT- IR-ATR spectroscopy to evaluate the penetration of surface sizing a- gents into the paper structure 显示文摘 | Ferreira P J Gamelas J A Moutinho I M | 2009 | Industrial & Engineering Chemis- try Research2009，48，8： | 1 |
| 15 | Promoter CpG island hypermethylation of the DNA repair enzyme mgmt predicts clinical response to dacarbazine in a phase ii study for metastatic colorectal cancer 显示文摘 | Amatu A Sartore-Bianchi A Moutinho C | 2013 | Clin Cancer Res2013，19，8： | 1 |
| 16 | The association between metabolic syndrome and its components and heart failure in patients referred to a primary care facility 显示文摘 | COELHO F A MOUTINHO M A DE MIRANDA V A | 2007 | Alq Bras Cardiol2007，89，1： | 1 |
| 17 | Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis显示文摘 | Davalos V Moutinho C Villanueva A | 2012 | Oncogene2012，31，16： | 1 |
| 18 | Market orientation and performance: Modelling a neural network显示文摘 | Silva M Moutinho L Coelho A | 2009 | European Journal of Marketing2009，43，3： | 1 |
| 19 | The association between metabolic syndrome and its components and heart failure in patients referred to a primary care facility显示文摘 | Coelho F A Moutinho M A de Miranda V A | 2007 | Arq Bras Cardiol2007，89，1： | 1 |
| 20 | Flavour development via lipolysis of milkfats: changes in free fatty acid pool 显示文摘 | REGADO M A CRISTOYAO B M MOUTINHO C G | 2007 | Int J Food Sei Teehnol2007，42，： | 1 |
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