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| 1 | c-Met targeted therapy of cholangiocarcinoma显示文摘Cholangiocarcinoma continues to be a challenging disease to treat. Systemic therapy is used in unresectable disease, disease progression after surgery, and in the palliative setting. Unfortunately, results of multiple phase Ⅱ trials have rarely yielded positive results. As data on the molecular carcinogenesis of cholangiocarcinoma is developing, we are more able to understand the disease process and can use this understanding to create unique targeted therapies. We reviewed the role of c-Met/ hepatocyte growth factor (HGF) in the development of cholangiocarcinoma. Furthermore, we explored the use of the c-Met guided cascade as a target to treat cholangiocarcinoma. We reviewed the current use and options for future development of c-Met agents to treat this disease. | Matei P Socoteanu Frank Mott Gianfranco Alpini Arthur E Frankel | 2008 | World Journal of Gastroenterology2008，14，19： | 16 |
| 2 | Mapping novel genetic loci associated with female liver weight variations using Collaborative Cross mice显示文摘Background: Liver weight is a complex trait, controlled by polygenic factors and differs within populations. Dissecting the genetic architecture underlying these variations will facilitate the search for key role candidate genes involved directly in the hepatomegaly process and indirectly involved in related diseases etiology.Methods: Liver weight of 506 mice generated from 39 different Collaborative Cross(CC) lines with both sexes at age 20 weeks old was determined using an electronic balance. Genomic DNA of the CC lines was genotyped with high-density single nucleotide polymorphic markers.Results: Statistical analysis revealed a significant(P < 0.05) variation of liver weight between the CC lines, with broad sense heritability(H^2) of 0.32 and genetic coefficient of variation(CV_G) of 0.28. Subsequently, quantitative trait locus(QTL) mapping was performed, and results showed a significant QTL only for females on chromosome 8 at genomic interval 88.61-93.38 Mb(4.77 Mb). Three suggestive QTL were mapped at chromosomes 4, 12 and 13. The four QTL were designated as LWL1-LWL4 referring to liver weight loci 1-4 on chromosomes 8, 4, 12 and 13,respectively.Conclusion: To our knowledge, this report presents, for the first time, the utilization of the CC for mapping QTL associated with baseline liver weight in mice. Our findings demonstrate that liver weight is a complex trait controlled by multiple genetic factors that differ significantly between sexes. | Hanifa J.Abu-Toamih Atamni Maya Botzman Richard Mott Irit Gat-Viks Fuad A.Iraqi | 2018 | Animal Models and Experimental Medicine2018，1，3： | 3 |
| 3 | 丙戊酸钠的可接受性和耐受性,一种新型持续有效的颗粒制剂可以单药治疗3岁以上癫痫儿童 | Motte J. Pedespan J.M. Sevestre M. Chiron C. 王经纬 | 2006 | 世界核心医学期刊文摘(儿科学分册)2006，0，A03： | 2 |
| 4 | The adaptive significance of amphistomatic leaves 显示文摘 | Mott K A Gibson A G O'Leary J W | 1982 | Plant Cell Environ1982，9，： | 2 |
| 5 | Enhanced expression of the protein kinase substrate p36 in human hepatocellular carcinoma显示文摘 | Frohlich M Motte P Galvin K | 1990 | Mol Cell Biol1990，10，6： | 2 |
| 6 | Ectopic expression of the osteogenic master gene RUNX2 in melanoma显示文摘The transcription factor RUNX2 is the osteogenic master gene expressed in mesenchymal stem cells during osteogenic commitment as well as in pre-osteoblasts and early osteoblasts.However,RUNX2 is also ectopically expressed in melanoma and other cancers.Malignant melanoma(MM)is a highly metastatic skin cancer.The incidence of MM has increased considerably in the past half-century.The expression levels and mutation rates of genes such as BRAF,KIT,NRAS,PTEN,P53,TERT and MITF are higher in melanoma than in other solid malignancies.Additionally,transcription factors can affect cellular processes and induce cellular transformation since they control gene expression.Recently,several studies have identified alterations in RUNX2 expression.In particular,the regulation of KIT by RUNX2 and the increased expression of RUNX2 in melanoma specimens have been shown.Melanocytes,whose transformation results in melanoma,arise from the neural crest and therefore show'stemness'features.RUNX2 plays an important role in the re-activation of the MAPK and PI-3K/AKT pathways,thus endowing melanoma cells with a high metastatic potential.In melanoma,the most frequent metastatic sites are the lung,liver,brain and lymph nodes.In addition,bone metastatic melanoma has been described.Notably,studies focusing on RUNX2may contribute to the identification of an appropriate oncotarget in melanoma. | Maria Teresa Valenti Luca Dalle Carbonare Monica Mottes | 2018 | World Journal of Stem Cells2018，10，7： | 2 |
| 7 | Long-term outcome of com- bined modality therapy in retroperitoneal and deep-trunk soft-tis- sue sarcoum: analysis of prognostic factors显示文摘 | Youssef E Fontanesi J Mott M | 2002 | Int J Radiat Oncol2002，54，2： | 1 |
| 8 | Salutary effect of pigment epithelium-derived factor in diabetic nephropathy : evidence for antifibrogenic activities 显示文摘 | Wang J J Zhang SX Mott R | 2006 | Diabetes2006，55，6： | 1 |
| 9 | The role of ABO blood groups in the incidence of deep vein thrombosis 显示文摘 | Wautrecht J C Galle C Motte S | 1998 | Thromb Haemost1998，79，3： | 1 |
| 10 | Pigment epithelium-derived factor(PEDF) is an endogenous antiinflammatory factor 显示文摘 | Zhang SX Wang JJ Gao G Shao C Mott R Ma JX | 2006 | FASEB J2006，20，2： | 1 |
| 11 | Enhanced expression of the protein kinase substrate p36 in human hepatocellular carcinoma显示文摘 | Frohlich M Motte P Galvin K | 1990 | Mol Cell Biol1990，10，6： | 1 |
| 12 | Cerium treatments for temporary protection of electroplated steel 显示文摘 | MOTTE C MAURY N OLIVIER M G | 2005 | Surface and Coatings Technology2005，200，7： | 1 |
| 13 | Water uptake of internally mixed particles containing ammonium sulfate and dicarboxylic acids 显示文摘 | PRENNI A J DE MOTT P J KREIDENWEIS S M | 2003 | Atmos Environ2003，37，： | 1 |
| 14 | Reflection and refraction coefficients at a fluidsolid interface显示文摘 | G Mott | 2001 | The Jourilal of the Acoustical Society of America2001，50，2： | 1 |
| 15 | Measurements and simulation of inertial and high capillary number flow phenomena in gas-condensate relative permeability显示文摘 | MOTT R CABLE A SPEARING M | 2000 | SPE629322000，，： | 1 |
| 16 | Melanoma associated with pseudoepitheliomat ous hyperplasia: a case series and investigation into the role of epidermal growth factor receptor显示文摘 | Mott RT Rosonberg A Livingston S | 2002 | J Cutan Pathol2002，29，8： | 1 |
| 17 | Insulin resistance and in- sulin secretory dysfunction as precursors of noninsulind- edependent diabetes mellitus 显示文摘 | Lillioja S Mott D Spraul M | 1993 | N Eng J Med1993，329，27： | 1 |
| 18 | Novel biomarkers of mercury-induced autoimmune dysfunction:a cross-sectional study in Amazonian Brazil显示文摘 | Motts JA Shirley DL Silbergeld EK | 2014 | Environ Res2014，132，： | 1 |
| 19 | Therapeutic effects of pparalpha agonists on diabetic retinopathy in type l diabetes models显示文摘 | CHEN Y HU Y LIN M JENKINS AJ KEECH AC MOTT R | 2013 | Diabetes2013，62，1： | 1 |
| 20 | Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: A structure–activity study显示文摘 | Bryan T. Mott Ran He Xiaochun Chen Jennifer M. Fox Curt I. Civin Ravit Arav-Boger Gary H. Posner | 2013 | Bioorganic & Medicinal Chemistry2013，，： | 1 |
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