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| 1 | Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease显示文摘AIM: To evaluate the safety and feasibility of bone marrow cell (BMC) transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS: Ten patients (eight males) with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 ml of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS: The median age of the patients was 52 years (range 24-70 years). All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 (2.19 ± 0.9) and 4 mo (2.10 ± 1.0) after cell transplantation that baseline levels (2.78 ± 1.2). Albumin levels 4 mo after BMC infusion (3.73 ± 0.5) were higher than baseline levels (3.47 ± 0.5). International normalized ratio (INR) decreased from 1.48 (SD = 0.23) to 1.43 (SD = 0.23) one month after cell transplantation. CONCLUSION: BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease. | Andre Castro lyra Milena Botelho Pereira Soares luiz Flavio Maia da Silva Marcos Fraga Fortes André Goyanna Pinheiro Silva Augusto César de Andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson Andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz Guilherme Costa lyra | 2007 | World Journal of Gastroenterology2007，13，7： | 21 |
| 2 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 3 | 3D additive manufactured composite scaffolds with antibiotic-loaded lamellar fillers for bone infection prevention and tissue regeneration显示文摘Bone infections following open bone fracture or implant surgery remain a challenge in the orthopedics field.In order to avoid high doses of systemic drug administration,optimized local antibiotic release from scaffolds is required.3D additive manufactured(AM)scaffolds made with biodegradable polymers are ideal to support bone healing in non-union scenarios and can be given antimicrobial properties by the incorporation of antibiotics.In this study,ciprofloxacin and gentamicin intercalated in the interlamellar spaces of magnesium aluminum layered double hydroxides(MgAl)andα-zirconium phosphates(ZrP),respectively,are dispersed within a thermoplastic polymer by melt compounding and subsequently processed via high temperature melt extrusion AM(~190◦C)into 3D scaffolds.The inorganic fillers enable a sustained antibiotics release through the polymer matrix,controlled by antibiotics counterions exchange or pH conditions.Importantly,both antibiotics retain their functionality after the manufacturing process at high temperatures,as verified by their activity against both Gram+and Gram-bacterial strains.Moreover,scaffolds loaded with filler-antibiotic do not impair human mesenchymal stromal cells osteogenic differentiation,allowing matrix mineralization and the expression of relevant osteogenic markers.Overall,these results suggest the possibility of fabricating dual functionality 3D scaffolds via high temperature melt extrusion for bone regeneration and infection prevention. | María C´amara-Torres Stacy Duarte Ravi Sinha Ainhoa Egizabal Noelia´Alvarez Maria Bastianini Michele Sisani Paolo Scopece Marco Scatto Alessandro Bonetto Antonio Marcomini Alberto Sanchez Alessandro Patelli Carlos Mota Lorenzo Moroni | 2021 | Bioactive Materials2021，6，4： | 2 |
| 4 | Finite element dynamic analysis of practical disc 显示文摘 | Mota Soares C A Petyt M | 1978 | J Sound Vibr1978，61，： | 2 |
| 5 | NEW TOXOPLASMA GONDII GENOTYPES ISOLATED FROM FREE-RANGE CHICKENS FROM THE FERNANDO DE NORONHA, BRAZIL: UNEXPECTED FINDINGS显示文摘 | Dubey J P Rajendran C Costa D G C Ferreira L R Kwok O C H Qu D Su C Marvulo M F V Alves L C Mota R A Silva J C R | 2010 | The Journal of Parasitology2010，，4： | 2 |
| 6 | Genetic polymorphism,medical therapy and sequential cardiac function in patients with heart failure显示文摘 | CUOCO M A PEREIRA A C MOTA GDE F | 2008 | Arq Bras Cardiol2008，90，： | 1 |
| 7 | Improvement for Mass-exchange Networkr Design显示文摘 | Castro P Motas H Femandes M C | 1999 | Chemical Engineering Science1999，54，11： | 1 |
| 8 | Optimal design for active damping in sandwich structures using the Direct MultiSearch method 显示文摘 | Araujo A L Madeira J F A Mota Soares C M | 2013 | Composite Structures2013，105，： | 1 |
| 9 | Established human papillomavirus type 16 expressing tumors are effective ly eradicated following vaccination with long peptides 显示文摘 | Zwaveling S Ferreira Mota S C Nouta J | 2002 | J Immunol2002，169，1： | 1 |
| 10 | Towards property oriented testing 显示文摘 | MACHADO P D L SILVA D A MOTA A C | 2007 | Electrical Notes in Theoretical Computer Science2007，184，： | 1 |
| 11 | Preferential ammonium uptake during growth cycle and identification of ammonium transporter genes in young pear trees 显示文摘 | Mota M Neto C B Monteiro A A | 2011 | Journal of Plant Nutrition2011，34，6： | 1 |
| 12 | Biodegradation of colorants in refinery effluents : potential use of the fungus Phanerochaete chrysosporium显示文摘 | Guimaraes C Bento L S M Mota M | 1999 | International Sugar Journal1999，101，： | 1 |
| 13 | The metabolic syndome-a multifaced disease显示文摘 | Mota M Panus C Mota E | 2004 | Rom J Intern Med2004，42，2： | 1 |
| 14 | Development of a finite element model for the identification of mechanical and piezoelectric properties through gradient optimization and experimental vibration data显示文摘 | Araujo A L Mota Soares C M Herskovits J | 2002 | Composite Structures2002，58，： | 1 |
| 15 | Lupus relapse presented as frosted branch retinal angiitis:case report显示文摘 | Hemandez-Da Mota SE Arellanes-Garcia L Recillas-Gispert C | 2011 | Ocul Immunol Inflamm2011，19，： | 1 |
| 16 | Rational design and optimization of downstream processes of virus particles for biopharmaceutical applications: current advances显示文摘 | Vicente T Mota JP Peixoto C | 2011 | Biotechnol Adv2011，29，6： | 1 |
| 17 | Molecular typing of Pyrus based on RAPD markers显示文摘 | Oliveira C M Mota M Monte Corvo L | 1999 | Sci Hort1999，79，： | 1 |
| 18 | The thyroid and autoimmtmity显示文摘 | Lichiardopol C Mota M | 2009 | Rom J Intern Med2009，47，3： | 1 |
| 19 | Endothelial nitric oxide synthase gene variant modulates the relationship between serum cholesterol levels and blood pressure in the general population:new evidence for a direct effect of lipids in arterial blood pressure显示文摘 | Pereira A C Sposito A C Mota G F | 2006 | Atherosclerosis2006，184，1： | 1 |
| 20 | Direct organogenesis from hypocotyl-derived explants of annatto ( Bixa orellana ) 显示文摘 | Paiva N V B da Mota T R Otoni W C | 2003 | Plant Cell Tissue and Organ Culture2003，75，2： | 1 |
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