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| 1 | Intensivist-based deep sedation using propofol for pediatric outpatient flexible bronchoscopy显示文摘AIM To evaluate the safety and efficacy of sedating pediatric patients for outpatient flexible bronchoscopy.METHODS A retrospective chart review was conducted for all children, age 17 years or under who underwent flexible bronchoscopy under deep sedation in an outpatient hospital-based setting. Two sedation regimens were used; propofol only or ketamine prior to propofol. Patients were divided into three age groups; infants(less than 12 mo), toddlers(1-3 years) and children(4-17 years). Demographics, indication for bronchoscopy, sedative dosing, sedation and recovery time and adverse events were reviewed.RESULTS Of the total 458 bronchoscopies performed, propofol only regimen was used in 337(74%) while propofol and ketamine was used in 121(26%). About 99% of the procedures were successfully completed. Children in the propofol + ketamine group tend to be youngerand have lower weight compared to the propofol only group. Adverse events including transient hypoxemia and hypotension occurred in 8% and 24% respectively. Median procedure time was 10 min while the median discharge time was 35 min. There were no differences in the indication of the procedure, propofol dose, procedure or recovery time in either sedative regimen. When compared to other age groups, infants had a higher incidence of hypoxemia.CONCLUSION Children can be effectively sedated for outpatient flexible bronchoscopy with high rate of success. This procedure should be performed under vigilance of highly trained providers. | Kamal Abulebda Samer Abu-Sultaneh Sheikh Sohail Ahmed Elizabeth A S Moser Renee C McKinney Riad Lutfi | 2017 | World Journal of Critical Care Medicine2017，6，4： | 8 |
| 2 | Aberrant Th2 inflammation drives dysfunction of alveolar macrophages and susceptibility to bacterial pneumonia显示文摘The ubiquitin ligase,Itch,is required to prevent autoinflammatory disease in mice and humans.Itch-deficient mice develop lethal pulmonary inflammation characterized by the production of Th2 cytokines(for example,interleukin-4(IL-4));however,the contribution of Itch to immune defense against respiratory pathogens has not been determined.We found that Itch-deficient mice were highly susceptible to intranasal infection with the respiratory pathogen Klebsiella pneumoniae.Infected Itch-deficient mice exhibited increased immune cell infiltration,cytokine levels and bacterial burden in the respiratory tract compared with control mice.However,numbers of resident alveolar macrophages were reduced in the lungs from Itch-deficient mice both before and after infection.High levels of Th2 cytokines in the respiratory tract correlated with deceased alveolar macrophages,and genetic ablation of IL-4 restored alveolar macrophages and host defense to K.pneumoniae in Itch-deficient mice,suggesting that loss of alveolar macrophages occurred as a consequence of Th2 inflammation.Adoptive transfer of Itch−/−CD4+T cells into Rag−/−mice was sufficient to drive reduction in numbers of Itch-replete alveolar macrophages.Finally,we found that Stat6 signaling downstream of the IL-4 receptor directly reduced fitness of alveolar macrophages when these cells were exposed to the Itch−/−inflamed respiratory tract.These data suggest that Th2 inflammation directly impairs alveolar macrophage fitness in Itch−/−mice,and elucidate a previously unappreciated link between Th2 cells,alveolar macrophages and susceptibility to bacterial infection. | Emily K Moser Natania S Field Paula M Oliver | 2018 | Cellular & Molecular Immunology2018，15，5： | 2 |
| 3 | Hydroxyethyl starch reduces the chemotaxis of white cells through endothelial cell monolayersn 显示文摘 | Hofbauer R Moser D Hornykeycz S | 1999 | Transfusion1999，39，3： | 1 |
| 4 | Mineral compo- sition of the grains oftropical maizevarieties as affect- ed by pre-anthesis drought andrate of nitrogen fertili- zation显示文摘 | Feil B Moser S B Jampatong S | 2005 | Crop Science2005，45，： | 1 |
| 5 | Semantic Integration of Software and Sys- tems Engineering Environments 显示文摘 | Moser T Biffl S | 2012 | Systems Man and Cy- bernetics Part C : Applications and Reviews IEEE Transac- tions on IEEE Transactions on2012，42，1： | 1 |
| 6 | LIM-domain proteincysteine-and glycine-rich protein 2(CRP2)is a novel marker ofhepaticstellate cells and binding partner of the protein inhibitor of activatedSTAT1显示文摘 | Weiskirchen R Moser M Weiskirchen S | 2001 | The Biochemical journal2001，359，3： | 1 |
| 7 | Heparanase-1 gene expression in normal,hyperplastic and neoplastic tissue显示文摘 | Stadlmann S Moser PL Pollheir J | 2003 | Eur J Cancer2003，39，15： | 1 |
| 8 | Activating transcriptionfactor-3(ATF3)functions as a tumor suppressor in colon cancer andis up-regulated upon heat-shock protein 90(Hsp90)inhibition显示文摘 | HACKL C LANG S A MOSER C | 2010 | BMC Cancer2010，10，： | 1 |
| 9 | Production ofsunflower oil methyl esters by optimized alkali-catalyzedmethanolysis显示文摘 | Rashid U Anwar F Moser B R Ashraf S | 2008 | Biomass and Bioenergy2008，32，12： | 1 |
| 10 | Spin polarized tunneling throughsingle-crystal GaAs(001) barriers显示文摘 | Kreuzer S Moser J Wegscheider W | 2002 | Appl Phys Lett2002，80，： | 1 |
| 11 | Partially supervised classification of remote sansing images through SVM-based probability density estimation 显示文摘 | MANTERO P MOSER G SERPICO S B | 2005 | IEEE Transactions on Geoscience and Remote Sensing2005，43，3： | 1 |
| 12 | Histopathological- regression grading matches excellently with local and re- gional spread after neoadjuvant therapy of rectal cancer显示文摘 | Elezkurtaj S Moser L Budczies J | 2013 | Pathol Res PractPathology Research and Practice2013，209，7： | 1 |
| 13 | The relationship of oral chlorpyrifos effects on behavior,cholinesterase inhibition,and muscarinic receptor density in rat显示文摘 | Nostrandt AC Padil a S Moser VC | 1997 | Pharmacol Biochem Behav1997，58，1： | 1 |
| 14 | Mineral composition of the grains of tropical maize varieties as affected by drought and rate of nitrogen fertilization显示文摘 | Feil B Moser S B Jampatong S | 2005 | Crop Science2005，45，： | 1 |
| 15 | A rapid crosstalk of human gamma delta T cells and monocytes drives the acute inflammation in bacterial infections显示文摘 | Eberl M Roberts GW Meuter S Williams JD Topley N Moser B | 2009 | PLoS Pathog2009，5，10： | 1 |
| 16 | Angiostatin binds ATP synthase on the surface of human endothelial cells显示文摘 | Moser T L Stack M S Asplin I | 1999 | Proc Natl Acad Sci USA1999，96，6： | 1 |
| 17 | Differential detection of key enzymes of polyaromatic-hydrocarbon-degradingbacteria using PCR and gene probes显示文摘 | Meyer S Moser R Neef A Stahl U Kampfer P | 1999 | Microbiology1999，145，： | 1 |
| 18 | A stable quasi-solid-state dye-sensitized solar cell with an amphiphilic ruthenium sensitizer and polymer gel electrolyte显示文摘 | Wang P Zakeeruddin S M Moser J E Nazeeruddin M K Sekiguchi T Gr(a)tzel M | | 0，，： | 1 |
| 19 | The relationship of oral chlorpyrifos effects on behavior cholinesterase inhibition and muscarinic receptor density in rat显示文摘 | Padilla S Moser VC | 1997 | Pharmacology Biochemistry and Behaviour1997，58，： | 1 |
| 20 | Stable new sensitizer with improved light harvesting for nanocrystalline dye-sensitized solar cells显示文摘 | P Wang S M Zakeeruddin J E Moser | 2004 | Adv Mater2004，16，： | 1 |
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