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| 1 | RNA-binding protein LIN28B inhibits apoptosis through regulation of the AKT2/FOXO3A/BIM axis in ovarian cancer cells显示文摘LIN28B is an evolutionarily conserved RNA-binding protein that regulates mRNA translation and miRNA let-7 maturation in embryonic stem cells and developing tissues.Increasing evidence demonstrates that LIN28B is activated in cancer and serves as a critical oncogene.However,the underlying molecular mechanisms of LIN28B function in tumorigenesis are still largely unknown.Here we report that LIN28B was expressed in over half of the patients with epithelial ovarian cancer who were examined(n=584).Functional experiments demonstrated that LIN28B inhibited ovarian cancer cell apoptosis.Furthermore,we showed that the proapoptotic factor BIM played an essential role in the antiapoptotic function of LIN28B.RNA-IP microarray analysis suggested that LIN28B binds to mRNAs that are associated with the DNA damage pathway,such as AKT2,in ovarian cancer cells.By binding to AKT2 mRNA and enhancing its protein expression,LIN28B regulated FOXO3A protein phosphorylation and decreased the transcriptional level of BIM,which antagonized the antiapoptosis activity of LIN28B.Taken together,these results mechanistically linked LIN28B and the AKT2/FOXO3A/BIM axis to the apoptosis pathway.The findings may have important implications in the diagnosis and therapeutics of ovarian cancer. | Xiaojuan Lin Jianfeng Shen Dan Peng Xinhong He Congjian Xu Xiaojun Chen Janos LTanyi Kathleen Montone Yi Fan Qihong Huang Lin Zhang Xiaomin Zhong | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 8 |
| 2 | Quantitative analysis of γ-oryzanol content in cold pressed rice bran oil by TLC-image analysis method显示文摘Objective:To develop and validate an image analysis method for quantitative analysis ofγ-oryzanol in cold pressed rice bran oil.Methods:TLC-densitometric and TLC-image analysis methods were developed,validated,and used for quantitative analysis of γ-oryzanol in cold pressed rice bran oil.The results obtained by these two different quantification methods were compared by paired t-test.Results:Both assays provided good linearity,accuracy,reproducibility and selectivity for determination of γ-oryzanol.Conclusions:The TLC-densitomelric and TLC-image analysis methods providett a similar reproducibility,accuracy and selectivity for the quantitative determination of γ-oryzanol in cold pressed rice bran oil.A statistical comparison of the quantitative determinations of γ-oryzanol in samples did not show any statistically significant difference between TLC-densitometric and TLC-image analysis methods.As both methods were found to be equal,they therefore can be used for the determination of γ-oryzanol in cold pressed rice bran oil. | Apirak Sakunpak Jirapornchai Suksaeree Chaowalit Monton Pathamaporn Pathompak Krisana Kraisintu | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，2： | 7 |
| 3 | Lung inflammatory response in pneumonia Monaldi Arch显示文摘 | Monton C Torres A | 1998 | Chest Dis1998，53，1： | 2 |
| 4 | Helicobacter pylori Is Not Eradicated after Triple Therapy: A Nested PCR Based Study显示文摘 | Saurabh Kumar Patel Girish Narayan Mishra Chandra Bhan Pratap Ashok Kumar Jain Gopal Nath Kathleen Montone | 2014 | BioMed Research International2014，，： | 2 |
| 5 | Metabolome analysis by capillary electrophoresis-mass spectrometry 显示文摘 | MONTON M R SOGA T | 2007 | J Chromator A2007，1168，12： | 1 |
| 6 | Angiotensin II AT(1) receptor antagonists and platelet activation 显示文摘 | Opez-Farre A Sanchez de Miguel L Monton M Jimenez A Lopez-Bloya A Gomez J | 2001 | Nephrol Dial Transplant2001，16，1： | 1 |
| 7 | Comparison of systemic cytokine levels in patients with acute respiratory distress syndrome severe pneumonia,and controls显示文摘 | Bauer TT Monton C Torres A | 2000 | Thorax2000，55，1： | 1 |
| 8 | Comparison of systemic cytokine levels in patients with acute respiratory distress syndrome, severe pneumonia, and controls显示文摘 | Bauer T T Monton C Torres A | 2000 | Thorax2000，55，1： | 1 |
| 9 | Magnetic fabric anisotropy of Plio-Pleistocene sediments from the Adriatic margin of the Northern Apennines (Italy): implications for the time-space evolution of the stress field 显示文摘 | Sagnotti L Winkler A Montone P | 1999 | Tectonophysics1999，311，： | 1 |
| 10 | Rapid method for detection of Aspergillus 5S ribosomal RNA using a genus-specific oligonucleotide probe显示文摘 | Montone K T Litzky L A | 1995 | Am J Clin Pathol1995，103，1： | 1 |
| 11 | Synthesis and characterization of PMMA/silylated MMTs 显示文摘 | Maria A D Aurora A Montone A | 2011 | J Nanopart Res2011，13，11： | 1 |
| 12 | High Levels of Systemic Myeloperoxidase Are Associated With Coronary Plaque Erosion in Patients With Acute Coronary Syndromes: A Clinicopathological Study显示文摘 | Giuseppe Ferrante Masataka Nakano Francesco Prati Giampaolo Niccoli Maria T. Mallus Vito Ramazzotti Rocco A. Montone Frank D. Kolodgie Renu Virmani Filippo Crea | 2010 | Circulation2010，，24： | 1 |
| 13 | Comparison of systemic cyto-kine levels in patients with acute respiratory distress syndrome,severe pneumonia,and controls显示文摘 | Bauer TT Monton C Torres A | 2000 | Thorax2000，55，1： | 1 |
| 14 | Separation of Isobutyl Alcohol and Isobutyl Acetate by Extractive Distillation and Pressure-Swing Distillation:Simulation and Optimization显示文摘 | Munoz R Monton J B Burguet M C | 2006 | Sep Purif Technol2006，50，2： | 1 |
| 15 | Separation of Di-nPropyl Ether and n-Propyl Alcohol by Extractive Distillation and Pressure-Swing Distillation:Computer Simulation and Economic Optimization显示文摘 | Lladosa E Monton J B Burguet M C | 2011 | Chem Eng Process2011，50，1112： | 1 |
| 16 | Fungal rhinosinusitis:a retrospective microbiologic and pathologic review of 400patients at a single university medical center显示文摘 | MONTONE K T LIVOLSI V A FELDMAN M D | 2012 | Int J Otolaryngol2012，2012，68： | 1 |
| 17 | Comparison of systemic cytokine levels inpatients with acute respiratory distress syndrome, severe pneumonia, and controls 显示文摘 | Torsten T Bauer Concepcion Monton Antoni Tortes | 2000 | Thorax2000，55，1： | 1 |
| 18 | Separation of Isobutyl Alcohol and Isobutyl Acetate by Extractive Distillation and Pressure-Swing Distillation:Simulation and Optimization显示文摘 | Munoz R Monton J B Burguet M C | 2006 | Sep Purif Technol2006，50，： | 1 |
| 19 | Ultra fast identification of Aspergillus species in pulmonary cytology specimens by in situ hybridization显示文摘 | Montone KT Fogt F | 2000 | Int J Mol Med2000，5，4： | 1 |
| 20 | Post-transplant lymphoproliferative disease in children 显示文摘 | Collins MH Montone KT Leahey AM | 2001 | Pediatr Transpl2001，5，4： | 1 |
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