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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | ProGRP: a new biomarker for small cell lung cancer显示文摘 | Molina R Filella X Auge J M | 2004 | Clinical Biochem2004，37，： | 1 |
| 3 | Reduced semenquality in chronic prostatitis patients that have cellularautoimmune response to prostate antigens显示文摘 | Motrich R D Maccioni M Molina R | 2005 | Hunm Reprod2005，20，9： | 1 |
| 4 | Reduced semen quality in chronic prostatitis patients that have cellular autoimmune response to prostate antigens 显示文摘 | Motrich RD Maccioni M Molina R | 2005 | Hum Reprod2005，20，9： | 1 |
| 5 | Carbon foam pre- pared by pyrolysis of olive stones under steam 显示文摘 | Rios R Martinez E M Molina S M | 2006 | Carbon2006，44，8： | 1 |
| 6 | Scripta Materialia显示文摘 | Tavangar R Molina J M Weber L | 2007 | 56(5): 3572007，56，5： | 1 |
| 7 | Hydroconversion of heptane over a Colombian montmorillonite modified with mixed pillars of Al Zr and Al-Si显示文摘 | Molina M F Molina R Moreno S | 2005 | Catalysis Today2005，，： | 1 |
| 8 | 显示文摘 | Almansa C Molina S M Rodriguez R F | 2004 | Microporous and Mesoporous Materials2004，76，3： | 1 |
| 9 | Switching of discrete optical solitons in engineered waveguide arrays显示文摘 | VICENCIO R A MOLINA M I KIVSHAR Y S | 2004 | PhysicalReview E2004，70，02： | 1 |
| 10 | The Hox gene abdominal-A specifies heart cell fate in the Drosophila dorsal vessel显示文摘 | Lovato T L Nguyen T P Molina M R | 2002 | Devel- opment2002，129，21： | 1 |
| 11 | Mapping Nanotechnology Patents: The EPO Approach 显示文摘 | Scheu M Veefkind V Verbandt Y Molina Galan E Ab- salom R Forster W | 2006 | World Patent Information2006，28，3： | 1 |
| 12 | Assessing therapeutic responsesin Kras mutant cancers using genetically engineerred mouse mod-els显示文摘 | Singh M Lima A Molina R | 2010 | Nat Biotechnol2010，28，6： | 1 |
| 13 | Drug therapy aud cere?bral perfusion in obsessive-compulsive disorder显示文摘 | Molina V Montz R Martin-Loeches M | 1995 | J Nucl Med1995，36，12： | 1 |
| 14 | Nutritive evaluation of legume seeds for ruminant feeding显示文摘 | Ramos-Morales E Sanz-Sampelayo M R Molina E | | 0，，： | 1 |
| 15 | The effects of divalent cations in the presence of phosphate, citrate and chloride on the aggregation of soy protein isolates显示文摘 | Molina M I Wagner J R | 1999 | Food Research International1999，32，： | 1 |
| 16 | A tenant-based resource allocation model for scaling software-as-a-service applications over cloud computing infrastructures显示文摘 | ESPADAS J MOLINA A JIMENEZ G1 MOLINA M RAMIRE R CONCHA D | 2013 | Future Generation Computer Systems2013，29，1： | 1 |
| 17 | Pressure infiltration of liquid aluminium into packed SiC particulate with a birnodal size distribution 显示文摘 | MOLINA J M SARAVANAN R A ARPON R | 2002 | Acta Mater2002，50，： | 1 |
| 18 | The effect of porosity on the thermal conductivity of Al-12wt% Si/SiC composites 显示文摘 | MOLINA J M PRIETO R NARCISO J | 2009 | Scripta Mater2009，60，7： | 1 |
| 19 | Sparse Bayesian meth- ods for low-rank matrix estimation显示文摘 | Babacan S D Luessi M Molina R | 2012 | IEEE Transactions on Sig- nal Processing2012，60，8： | 1 |
| 20 | Tumor markers in response monitoring and prognosis of non small cell lung cancer:preliminary report显示文摘 | Vinolas N Molina R Galan M C Casas F Callejas M A Filella X | 1998 | Anticancer Res1998，18，1： | 1 |
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