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| 1 | Molecular detection of monocyte chemotactic protein-1 polymorphism in spontaneous bacterial peritonitis patients显示文摘AIM: To investigate the association of the functional monocyte chemotactic protein-1(MCP-1) promoter polymorphism(A-2518G) with spontaneous bacterial peritonitis(SBP).METHODS: Fifty patients with post-hepatitis C liver cirrhosis and ascites were categorized into two groups; group Ⅰ included 25 patients with SBP and group Ⅱ included 25 patients free from SBP. In addition, a group of 20 healthy volunteers were included. We assessed the MCP-1 gene polymorphism and gene expression as well as interleukin(IL)-10 levels in both blood and ascitic fluid. RESULTS: A significant MCP-1 gene polymorphism was detected in groups Ⅰ and Ⅱ(P = 0.001 and 0.02 respectively). Group Ⅰ was associated with a significantly higher frequency of AG genotype [control 8(40%) vs SBP 19(76.0%), P < 0.001], and group Ⅱ was associated with a significantly higher frequency of GG genotype when compared to healthy volunteers [control 1(5%) vs cirrhotic 16(64%), P < 0.001]. Accordingly, the frequency of G allele was significantly higher in both groups(Ⅰ and Ⅱ) [control 10(25%) vs SBP 27(54%), P < 0.001 and vs cirrhotic 37(74.0%), P < 0.001, respectively]. The total blood and ascetic fluid levels of IL-10 and MCP-1 gene expression were significantly higher in group Ⅰ than in group Ⅱ. Group Ⅰ showed significant reductions in the levels of MCP-1 gene expression and IL-10 in the whole blood and ascetic fluid after therapy. CONCLUSION: MCP-1 GG genotype and G allele may predispose HCV infected patients to a more progressive disease course, while AG genotype may increase the susceptibility to SBP. Patients carrying these genotypes should be under supervision to prevent or restrict further complications. | Maysa Kamal Salama Dina Sabry Mohamed AS Al-Ghussein Rasha Ahmed Sayed AbdAllah Fatma Mohamed Taha Wael Fathy Miriam Safwat Wadie Mona Nabih Amr Abul-Fotouh Tarneem Darwish | 2014 | World Journal of Gastroenterology2014，20，33： | 7 |
| 2 | Human herpesvirus 8 infection in patients with POEMS syndrome-associated multicentric Castleman disease显示文摘 | Belec L Mohamed AS Authier FJ | 1999 | Blood1999，93，11： | 1 |
| 3 | Carbetocin versus syn- tometrine for prevention of postpartum hemorrhage after cesarean section显示文摘 | Mohamed Maged A Ragab AS | 2016 | J Matern Fetal Neonatal Med2016，，： | 1 |
| 4 | The prevalenceandriskfactors of urinary incontinence and its influence on the quality of life among egyptian women 显示文摘 | El- Azab AS Mohamed EM Sabra HI | 2007 | Neurourol Urodyn2007，26，6： | 1 |
| 5 | Preop- erative intravenous dexamethasone combined with glos- sopharyngeal nerve block: role in pediatric postopera- tive analgesia following tonsillectomy 显示文摘 | Mohamed SK Ibraheem AS Adelraheem MG | 2009 | Eur Otorhi nolaryngeal2009，266，： | 1 |
| 6 | Hepatie dys- function in kidney transplant recipients: prevalence and impact on graft and patient survival显示文摘 | Osama AG Mohamed AS Ahmed AH | 2007 | Clinical and Experimental Nephrology2007，11，4： | 1 |
| 7 | Evaluation of transvaginal slings using different materials in the management of female stress urinary incontinence 显示文摘 | MohamedT Emad AS Mohamed N | 2011 | Arab J Uro12011，9，4： | 1 |
| 8 | Ocular manifesta- tion of systemic lupus erythematosus显示文摘 | E1-Shereef RR Mohamed AS Hamdy L | 2013 | Rheumatol Int2013，33，6： | 1 |
| 9 | Human herpesvirus 8 in-fection in patients with POEMS syndrome-associated multicentricCastleman's disease显示文摘 | Belec L Mohamed AS Authier FJ | 1996 | Blood1996，93，11： | 1 |
| 10 | Human herpesvirus 8 infection in patients with POEMS syndrome-associated multicentric Castleman's disease显示文摘 | Belec L Mohamed AS Auther FJ | 1999 | Blood1999，93，： | 1 |
| 11 | The Arabic self--reporting questionnaire (SRQ) as a psychiatric screen- ing instrument in medical patients 显示文摘 | A1-- Subaie AS Mohammed K A1-- Malik T | 1998 | Annual of Saudi Med1998，18，4： | 1 |
| 12 | Human herpesirus 8infection in patients with POEMS syndnome -associatedmulticentrio Castleman s disease 显示文摘 | BelecL Mohamed AS Authier FJ | 1999 | Blood1999，93，6： | 1 |
| 13 | Kinase signaling cascade dysfunction specific to AD in fibroblasts显示文摘 | Zhao WQ Ravindranathe M Mohamed AS | 2002 | Neurobiol Dis2002，11，1： | 1 |
| 14 | Atlantoaxial rotatory subluxation in children 显示文摘 | Neal KM Mohamed AS | 2015 | J Am Acad Orthop Surg2015，23，6： | 1 |
| 15 | Quality by design: Understanding the formulation variables of a cyclosporine a self- nanoemulsified drug delivery systems by Box - Belmken design and desirability hmction 显示文摘 | Ahmed SZ Omaima AS Mohammed AH | 2007 | lnt J Pharma2007，332，： | 1 |
| 16 | Oxidized low density Ilpepretein,stem cells, and atherosclerosis显示文摘 | Yang H Mohamed AS Zhou SH | 2012 | Lipids Health Dis2012，11，1： | 1 |
| 17 | Human herpesvirus 8 infection in patients with POEMS syndrome-associated multicentric Castleman's disease显示文摘 | Iec L Mohamed AS Authier FJ | 1996 | Blood1996，93，11： | 1 |
| 18 | Human Herpesviins 8 infection in patients with POEMS syndrome-associated multicentric Castleman disease显示文摘 | Mohamed AS Authier FJ | 1999 | Blood1999，93，11： | 1 |
| 19 | The pre- sentation, incidence, etiology, and treatment of surgical site infec- tions after spinal surgery显示文摘 | Pull ter Gunne AF Mohamed AS Skolasky RL | 2010 | Spine2010，35，13： | 1 |
| 20 | Hepatic dysfunction in kidney transplant recipients: prevalence and impact on graft and pa- tient survival 显示文摘 | Osama AG Mohamed AS Ahmed AH | 2007 | Clinical and Experimental Nephrology2007，11，4： | 1 |
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