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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Dairy, calcium and vitamin D intake and postmenopausal breast cancer risk in the cancer prevention study II Nutrition Cohort 显示文摘 | Mc Cullough ML Rodriguez C | 2005 | Caneer Epidemiol Biomarkers Prey2005，14，12： | 1 |
| 3 | Endoscopic injection of ethanolamine as a treatment for achalasia: a first report显示文摘 | Ojembarrena E Rodriguez ML | 1996 | Enhdos-copy1996，28，7： | 1 |
| 4 | Visual acuity outcomes of patients 50 years of age and older with high myopia and untreated choroidal neovascularization显示文摘 | Tabandeh H Flynn HW Scott IU Lewis ML Rosenfeld PJ Rodriguez F | 1999 | Ophthalmology1999，106，： | 1 |
| 5 | Response to epidermal growth factor receptor inhibitors in non-small cell lung cancer cells:limited antiproliferative effects and absence of apoptosis associated with persistent activity of extracellular signal-regula-ted kinase or Akt kinase pathways显示文摘 | Janmaat ML Kruyt FA Rodriguez JA | 2003 | Clin Cancer Res2003，9，6： | 1 |
| 6 | Predictive factors for outcome in a phase Ⅱ study of gefitinib in second - line treatment of advanced esophageal cancer patients显示文摘 | Janmaat ML Gallegos-Ruiz MI Rodriguez JA | 2006 | Clin Oncol2006，24，10： | 1 |
| 7 | Predictive fac- tors for outcome in a phase II study of gefitinib in second-line treatment of advanced esophageal cancer patients 显示文摘 | Janmaat ML Gallegos-Ruiz MI Rodriguez JA | 2006 | J Clin On- col2006，24，10： | 1 |
| 8 | Critical update for the clinical use of L-carnitine analogs in cardio-Metabolic disorders显示文摘 | Mingorance C Rodriguez R Justo ML | 2011 | Vasc Health Risk Manag2011，7，： | 1 |
| 9 | Involvement of all-trans-retinoic acid in the breakdown of retinoic acid receptors alpha and gamma through proteasomes in MCF-7 human breast cancer cells显示文摘 | Tanaka T Rodriguez de la Concepci6n ML De Luca LM | 2001 | Biochem Pharmacol2001，61，11： | 1 |
| 10 | Re-sponse to epidermal growth factor receptor inhibitors in nonsmallcell lung cancer cells : limited antiproliferative effects and ab-sence of apoptosis associated with persistent activity of extracellu-lar signal-regulated kinase or Akt kinase pathways 显示文摘 | JANMAAT ML KRUYT FAE RODRIGUEZ JA el al | 2003 | ClinCancer Res2003，9，6： | 1 |
| 11 | Detoxi- fication of dilute acid hydrolysates of lignocellulose with lime显示文摘 | Martinez A Rodriguez ME Wells ML | 2001 | Biotechnol Prog2001，17，2： | 1 |
| 12 | Quantification of via-ble Escherichia coli 0157 : H7 in meat products by duplex real-timePCR assays 显示文摘 | Gordillo R Rodriguez A 'Werning ML | 2014 | Meat Sci2014，962，： | 1 |
| 13 | Detoxification of dilute acid hydrolysates of lignocellulose with lime显示文摘 | Martinez A Rodriguez ME Wells ML | 2001 | Biotechnol Progress2001，，17： | 1 |
| 14 | Inhibition of the epidermal growth factor receptor induces apoptosis in A431 cells but not in non-small-cell lung cancer cell lines 显示文摘 | Janmaat ML Kruyt FAE Rodriguez JA | 2002 | Proc Am Assoc Cancer Res2002，43，： | 1 |
| 15 | In vivo major histocom- patibility complex class I (MHCI) expression on MHCIIow tumor cells is regulated by gammadelta T J NK cells during the early steps of tumor growth显示文摘 | Riond J Rodriguez S Nicolau ML | 2009 | Cancer Immun2009，9，： | 1 |
| 16 | Toxoplasma gondii antibodies in Mexican blood donors 显示文摘 | Galvan Ramirez ML Covarrubias X Rodriguez R | 2005 | Transfusion2005，45，2： | 1 |
| 17 | Cytogenetic a- nalysis in the diagnosis and management of lipoblastomas: re- sults from a single institution 显示文摘 | Fallon SC Brandt ML Rodriguez JR | 2013 | J Surg Res2013，184，1： | 1 |
| 18 | Human platelets contain seinderin, a Ca2+ -dependent actin filament- severing protein 显示文摘 | Rodriguez Del Castillo A Vitale ML Tchakarov L | 1992 | Thromb Haemost1992，67，2： | 1 |
| 19 | Correlation between irnpression cytology and tear function parameters in Sjogen syndrome显示文摘 | Rives L Rodriguez J J Alvarez ML | 1993 | Acta Ophthalmologica1993，71，： | 1 |
| 20 | Calcium,Dairy Products,and Risk of Prostate Cancer in a Prospective Cohort of United States Men显示文摘 | Rodriguez C McCullough ML Mondul AM | 2003 | Cancer Epidemiol Biomarkers Prev2003，12，： | 1 |
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