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| 1 | Effects of binder strength and aggregate size on the compressive strength and void ratio of porous concrete显示文摘To test the influence of binder strength, porous concretes with 4 binder strengths between 30.0-135.0 MPa and 5 void ratios between 15%-35% were tested. The results indicated that for the same aggregate, the rates of strength reduction due to the increases in void ratio were the same for binders with different strengths. To study the influence of aggregate size, 3 single size aggregates with nominal sizes of 5.0, 13.0 and 20.0 mm (Nos. 7, 6 and 5 according to JIS A 5001) were used to make porous concrete. The strengths of porous concrete are found to be dependent on aggregate size. The rate of strength reduction of porous concrete with small aggregate size is found to be higher than that with larger aggregate size. At the same void ratio, the strength of porous concrete with large aggregate is larger than that with small aggregate. The general equations for porous concrete are related to compressive strength and void ratio for different binder strengths and aggregate sizes. | P. Chindaprasirt S. Hatanaka N. Mishima Y. Yuasa T. Chareerat | 2009 | International Journal of Minerals,Metallurgy and Materials2009，16，6： | 22 |
| 2 | 河北省不同利用方式农田土壤氮磷环境风险分析显示文摘弄清不同利用方式农田土壤氮磷养分平衡状况,进而明确其环境风险特征,为进一步指导土壤养分管理及环境政策制定具有重要意义。研究以河北省的粮田、果园和菜地为研究对象,通过分析三种利用方式氮磷的输入、化肥和有机肥的分配比例及氮磷养分的盈余状况,并结合化肥使用环境风险指数,评价三种不同利用方式化肥氮磷的环境风险类型。结果表明,氮总输入量为菜地明显高于果园和粮田,磷总输入量为菜地和果园明显高于粮田,且粮田和菜地氮磷输入主要以化肥为主。三种不同利用方式农田氮磷均呈盈余状态,其中氮盈余率为果园(532.6%)明显高于菜地(61.5%)和粮田(31.6%),磷盈余率为菜地(700.4%)和果园(615.7%)明显高于粮田(66.6%)。化肥氮磷的环境风险指数均为菜地(0.83)明显高于粮田(0.59-0.62),三种不同利用方式下化肥氮磷的环境风险类型均达低度风险及以上,特别是菜地达严重风险。为了农业的可持续发展,河北省粮田应控制氮磷肥的投入,果园和菜地应加大减少氮磷肥化肥投入,以减少对环境的潜在危害。同时为了更好地培肥地力,在控制施肥总量的前提下应加大粮田和菜地有机肥的投入比例。 | 李玲 段英华 徐明岗 Mishima Shin-Ichiro Chien Hsiaoping | 2016 | 中国农业资源与区划2016，37，7： | 14 |
| 3 | Effect of probiotic Lactobacillus plantarum Dad-13 powder consumption on the gut microbiota and intestinal health of overweight adults显示文摘BACKGROUND Shifting on lifestyle,diet,and physical activity contributed on increasing number of obese people around the world.Multiple factors influence the development of obesity.Some research suggested that gut microbiota(GM)plays an important role in nutrient absorption and energy regulation of individuals,thus affecting their nutritional status.Report of Indonesia Basic Health Research showed that the prevalence of obesity in every province tended to increase.Although the root cause of obesity is excessive calorie intake compared with expenditure,the differences in gut microbial ecology between healthy and obese humans may affect energy homeostasis.GM affect body weight,especially obesity.Probiotics that are consumed while alive and able to colonize in the intestine are expected to increase the population of good bacteria,especially Bifidobacteria and Lactobacilli,and suppress pathogens such as Enterobacteriaceae and Staphylococcus.The strain of L.plantarum Dad-13 has been demonstrated to survive and colonize in the gastrointestinal tract of healthy Indonesian adults who consume fermented milk containing L.plantarum Dad-13.The consumption of probiotic L.plantarum Dad-13 powder decreased E.coli and non-E.coli coliform bacteria in school-aged children in Indonesia.L.plantarum is a dominant bacterium in the average Indonesian’s GM.For this reason,this bacterium is probably a more suitable probiotic for Indonesians.AIM To determine the effect of the consumption of indigenous probiotic Lactobacillus plantarum Dad-13 powder in overweight adults in Yogyakarta(Indonesia).METHODS Sixty overweight volunteers with a body mass index(BMI)equal to or greater than 25 consume indigenous probiotic powder L.plantarum Dad-13(2×109 CFU/gram/sachet)for 90 d.The study was a randomized,double-blind,placebocontrolled study.The volunteers filled in a diary on a daily basis,which consisted of questions on study product intake(only during ingestion period),other food intake,number of bowel movements,fecal quality(consistency and color),any medications received,and any symptom of discomfort,such as diarrhea,constipation,vomiting,gassing,sensation of illness,etc.Fecal samples and the subjects’diaries were collected on the morning of day 10+1,which was marked as the end of the baseline period and the start of the ingestion period.During the ingestion period(from day 11 to day 101),several parameters to measure and analyze the results included body weight and height(once a month),the lipid profile,GM analysis using MiSeq,short-chain fatty acid(SCFA)analysis using gas chromatography,and the measurement of fecal pH using a pH meter.RESULTS The consumption of indigenous probiotic powder L.plantarum Dad-13 caused the average body weight and BMI of the probiotic group to decrease from 84.54±17.64 kg to 83.14±14.71 kg and 33.10±6.15 kg/m2 to 32.57±5.01 kg/m2,respectively.No significant reduction of body weight and BMI in the placebo group was observed.An analysis of the microbiota showed that the number of Bacteroidetes,specifically Prevotella,increased significantly,while that of Firmicutes significantly decreased.No significant change in lipid profile in both groups was found.Also,no significant change in SCFAs(e.g.,butyrate,propionate,acetic acid)and pH level was found after the consumption of the probiotic.CONCLUSION No significant differences in pH before and after ingestion were observed in both the probiotic and placebo groups as well as in the lipid profile of both cholesterol and triglyceride,high-density lipoprotein(HDL),low-density lipoprotein(LDL),and the LDL/HDL ratio.In addition,no significant changes in the concentration of SCFAs(e.g.,acetic acid,propionate,and butyrate)were found after consumption.Interestingly,a significant decrease in body weight and BMI(P<0.05)was determined in the treatment group.An analysis of GM shows that L.plantarum Dad-13 caused the Firmicutes population to decrease and the Bacteroidetes population(especially Prevotella)to increase. | Endang Sutriswati Rahayu Mariyatun Mariyatun Nancy Eka Putri Manurung Pratama Nur Hasan Phatthanaphong Therdtatha Riko Mishima Husnita Komalasari Nurul Ain Mahfuzah Fathyah Hanum Pamungkaningtyas Wahyu Krisna Yoga Dina Aulia Nurfiana Stefanie Yolanda Liwan Mohammad Juffrie Agung Endro Nugroho Tyas Utami | 2021 | World Journal of Gastroenterology2021，27，1： | 6 |
| 4 | Hemorrhagic shock due to submucosal esophageal hematoma along with mallory-weiss syndrome:A case report显示文摘BACKGROUND Esophageal submucosal hematoma is a rare condition.Although the exact etiology remains uncertain,vessel fragility with external factors is believed to have led to submucosal bleeding and hematoma formation;the vessel was ruptured by a sudden increase in pressure due to nausea,and the hematoma was enlarged by antiplatelet or anticoagulant therapy.Serious conditions are rare,with a better prognosis.We present the first known case of submucosal esophageal hematoma-subsequent hemorrhagic shock due to Mallory-Weiss syndrome.CASE SUMMARY A 73-year-old female underwent endovascular treatment for an unruptured cerebral aneurysm.The patient received aspirin and clopidogrel before surgery and heparin during surgery,and was well during the surgery.Several hours after returning to the ICU,she complained of chest discomfort,vomited 500 m L of fresh blood,and entered hemorrhagic shock.Esophageal submucosal hematoma with Mallory-Weiss syndrome was diagnosed through an endoscopic examination and computed tomography.In addition to a massive fluid and erythrocyte transfusion,we performed a temporary compression for hemostasis with a Sengstaken-Blakemore(S-B)tube.Afterwards,she became hemodynamically stable.On postoperative day 1,we performed an upper gastrointestinal endoscopy and confirmed no expansion of the hematoma nor any recurring bleeding;therefore,we removed the S-B tube and clipped the gastric mucosal laceration at the esophagogastric junction.We started oral intake on postoperative day 10.The patient made steady progress,and was discharged on postoperative day 33.CONCLUSION We present the first known case of submucosal esophageal hematoma subsequent hemorrhagic shock due to Mallory-Weiss syndrome. | Jiro Oba Daisuke Usuda Shiho Tsuge Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki Hayabusa Takano Shintaro Shimozawa Yuta Hotchi Kenki Usami Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita | 2022 | World Journal of Clinical Cases2022，10，27： | 3 |
| 5 | Effects of Y(Ⅲ) Ions on the Fluorescence Properties of Ce(Ⅲ) Ion and the Organic Ligands in the Comp显示文摘EffectsofY(Ⅲ)IonsontheFluorescencePropertiesofCe(Ⅲ)IonandtheOrganicLigandsintheComplexLIWen-lian.(ChangchunInstituteofPhysics... | LI Wen-lian. (Changchun Institute of Physics and the Excited State Process Laboratory, Chinese Academy of Sciences , Changchun , 1 30021 ) Takayuku Mishima , Gin-Ya Adachi and Jiro Shiokawa (Department of Applied Chemistry, Faculty of Engineering, | 1997 | Chemical Research in Chinese Universities1997，13，3： | 3 |
| 6 | The Effect of Flow Direction on CHF for Low Pressure Water in Thin Rectangular Channel 显示文摘 | Mishima K Nishihara H | 1985 | Nuclear Engineering and Design1985，86，： | 2 |
| 7 | Angiotensin receptor blocker neprilysin inhibitors显示文摘Heart failure(HF)is a clinical syndrome that results from a structural or functional cardiac disorder that reduces the ability of the ventricle of the heart to fill with,or eject,blood.It is a multifaceted clinical condition that affects up to 2%of the population in the developed world,and is linked to significant morbidity and mortality;it is therefore considered a major concern for public health.Regarding the mechanism of HF,three neurohumoral factors-the reninangiotensin-aldosterone system,the sympathetic nervous system,and natriuretic peptides—are related to the pathology of chronic HF(CHF),and the targets of treatment.Angiotensin receptor blocker and neprilysin inhibitor(angiotensinreceptor neprilysin inhibitor),namely sacubitril/valsartan(SAC/VAL),has been introduced as a treatment for CHF.SAC/VAL is an efficacious,safe,and costeffective therapy that improves quality of life and longevity in patients with HF with reduced ejection fraction(HFrEF),and reduces hospital admissions.An inhospital initiation strategy offers a potential new avenue to improve the clinical uptake of SAC/VAL.In the last five years,SAC/VAL has been established as a cornerstone component of comprehensive disease-modifying medical therapy in the management of chronic HFrEF.On the other hand,further work,with carefully designed and controlled preclinical studies,is necessary for understanding the molecular mechanisms,effects,and confirmation of issues such as long-term safety in both human and animal models. | Daisuke Usuda Toshihiro Higashikawa Yuta Hotchi Kenki Usami Shintaro Shimozawa Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Toshihiko Yoshizawa Suguru Asako Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Jiro Oba Tomohisa Nomura Manabu Sugita | 2021 | World Journal of Cardiology2021，13，8： | 2 |
| 8 | FAP-1 and NF-κB expressions in oral squamous cell carcinoma as potential markers for chemo-radio sensitivity and prognosis显示文摘 | Y. Nariai K. Mishima Y. Yoshimura J. Sekine | 2010 | International Journal of Oral & Maxillofacial Surgery2010，，4： | 2 |
| 9 | Differential analysis of experimental hypermelanosis induced by UVB, PUVA, and allergic contact dermatitis using a brownish guinea pig model显示文摘 | Imokawa G Kawai M Mishima Y | 1986 | Arch Dermatol Res1986，278，： | 2 |
| 10 | Correlation between the number of melanosomes,tyrosinase mRNA levels,and tyrosinase activity in cultured murine melanoma cells in response to various melanogenesis regulatory agents显示文摘 | Itoh A Mishima Y | 1995 | J Cell Physiol1995，163，3： | 1 |
| 11 | Senescence-associated beta-galactosidase histochemistry for the primate eye显示文摘 | Mishima K Handa JT Aotaki-Keen A | 1999 | Invest Ophthalmol Vis Sci1999，40，7： | 1 |
| 12 | A new family of macrolide antibodies: fermentation,isolation and physico-chemical properties显示文摘 | Takiguchi Y Mishima H Okuda M | 1980 | J Antibiot1980，33，： | 1 |
| 13 | Characterstics of nitrification of the media-anaerobic-anoxicoxic process显示文摘 | Koji Mishima Takahiko Nishimura Masahide Goi | 1996 | Water Sci Technol1996，34，12： | 1 |
| 14 | Modified protection against Toxoplasma gondii lethal infection and brain cyst formation by vaccination with SAG2 and SRS1显示文摘 | MISHIMA M XUAN X SHIODA A | 2001 | Vet Med Sci2001，63，4： | 1 |
| 15 | A Study of the Dizcharge Procezs of Manganese Oxide in Borate Solution Using in situ Techniques 显示文摘 | Mishima B A L D Ohtsuka T Sato N | 1993 | Electrochimica Acta ( SO013 -4686 )1993，38，： | 1 |
| 16 | Autolmmune pancreatltis with extreme elevation of DUPAN-2 显示文摘 | Mishima S Mizuta Y Yamao T | 2007 | Intern Med2007，46，7： | 1 |
| 17 | Polymers and copolymers of pyrrole and thiophene as electrodes in lithium cells显示文摘 | M. I. SANCHEZ DE PINTO H. T. MISHIMA B. A. LO′PEZ DE MISHIMA | 1997 | Journal of Applied Electrochemistry1997，，7： | 1 |
| 18 | Thermal damage threshold of brain tissue-histological study of heated normal monkey brains 显示文摘 | Matsumi N Matsumoto K Mishima N | 1994 | Neurol Med Chit (Tokyo)1994，34，4： | 1 |
| 19 | Proteasome assembly defect due to a proteasome subunit beta type 8(PSMB8)mutation causes the autoinflammatory disorder,Nakajo-Nishimura syndrome显示文摘 | Arima K Kinoshita A Mishima H | 2011 | Proc Natl Acad Sci USA2011，108，14： | 1 |
| 20 | A practical ZCS-PWM boost DCDC converter with clamping diode-assisted active edge-resonant cell and its extended topologies显示文摘 | MISHIMA T NAKAOKA M | 2013 | IEEE Transactions on Industrial Electronics2013，60，6： | 1 |
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