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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | 世界人口发展趋势预示危险前兆显示文摘联合国公布的人口数据证实,全球人口的长期趋势仍呈持续增长态势,全球人口数量要大于此前的预测值.各同已承担不起尤视发展趋势造成的后果,这些趋势包括:大多数周家生育率下降,而另一些国家在推行计划生育政策方面力度有限,老龄人口的持续增加和城市化进程的加速构成新的挑战。 | Barry Mirkin 王超 | 2014 | 英语文摘2014，，6： | 2 |
| 3 | Programmed assembly of DNA functionalized quantum dots 显示文摘 | MITCHELL G P MIRKIN C A LETSINGER R L | 1999 | J Am Chem Soc1999，121，35： | 1 |
| 4 | Array-based elect rical detection of DNA wit h nanoparticle probes显示文摘 | Park SJ Taton TA Mirkin CA | 2002 | Science2002，295，5559： | 1 |
| 5 | ScanometricDNA array detection with nanoparticle probes显示文摘 | Taton T A Mirkin C A Letsinger R L | 2000 | Science2000，289，5485： | 1 |
| 6 | A DNA-based method for rationally assembling nanoparticles into macroscopic materials 显示文摘 | MIRKIN C A LETSINGER R L MUCIC R C | 1996 | Letters to Nature1996，382，15： | 1 |
| 7 | Feature weighting and anomalous cluster initializing in K-Means clustering 显示文摘 | Amorim R C Mirkin B Minkowski M | 2012 | Pattern Recognition2012，45，3： | 1 |
| 8 | Some remarks on the use of time-varying delay to model sample-and-hold circuits显示文摘 | Mirkin L | 2007 | IEEE Transactions on Automatic Control2007，52，6： | 1 |
| 9 | A Nanoplotter with both parallel and serial writing capabilities 显示文摘 | MIRKIN C | 2000 | Science2000，288，： | 1 |
| 10 | Gene expression profilesand structural/functional features of the peri-implantation endometrium in natural and gonadotropin-stimulated cycles 显示文摘 | Mirkin S Nikas G Hsiu JG | 2004 | J Clin Endocrinol Metab2004，89，： | 1 |
| 11 | 查看详情显示文摘 | Cai C X Mirkin M V | | 0，，01： | 1 |
| 12 | Colorimetric Screening of DNA-Binding Molecules with Gold Nanoparticle Probes显示文摘 | Han M S Lytton-Jean A K R Mirkin C A | | 0，，： | 1 |
| 13 | Effects of bazedoxifene/ conjugated estrogens on endometrial safety and bone in postme- nopausalwomen 显示文摘 | Mirkin S Komm BS Pan K | 2013 | Climacteric2013，16，3： | 1 |
| 14 | Photoinduced conversion of silver nanospheres to nanoprisms 显示文摘 | Jin R C Cao Y W Mirkin C A | 2001 | Sci- ence2001，294，： | 1 |
| 15 | A DNA based method for rationally assembling nanoparti- cles into macroscopic materials 显示文摘 | Mirkin C A Letsinger R L Mucic R C () | 1996 | Nature1996，382，： | 1 |
| 16 | 显示文摘 | Mirkin C A Letsinger R L | 1996 | Nature1996，382，60： | 1 |
| 17 | H~ control and estimation with preview-part II: fixed-size ARE solutions in discrete time显示文摘 | TADMOR G MIRKIN L | 2005 | IEEE Transactions on Automatic Control2005，50，1： | 1 |
| 18 | Oligonucleotide - Modified Gold Nanoparticles for Intracellular Gene Regulation 显示文摘 | Rosi N L Giljohann D A Thaxton S C Lytton -Jean A K Han M S Mirkin C A | 2006 | Science2006，312，5776： | 1 |
| 19 | Dynamic interconversion of amorphous microparticles and crystalline rods in salen-based homochiral infinite coordination polymers 显示文摘 | Jeon Y M Heo J Mirkin C A | 2008 | J Am Chem Soc2008，129，： | 1 |
| 20 | A DNA-based method for rationally assembling nanopartic les into macroscopic materials显示文摘 | Letsinger R L Mucic R C | 1996 | Nature1996，382，： | 1 |
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