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| 1 | 乳腺单纯型大汗腺癌代表一种独特的雄激素受体阳性的三阴型乳腺癌亚型显示文摘乳腺单纯型大汗腺癌在所有乳腺癌中不足1%,是一种胞质内富含嗜酸性颗粒,核圆形,核仁明显的乳腺癌,肿瘤ER、PR及HER-2均阴性,对基于激素和HER-2方案的化疗无效,因此通常被归为三阴型乳腺癌进行治疗,甚至部分病例接受强化化疗。但与其他类型三阴型乳腺癌不同的是,该亚型乳腺癌表达雄激素受体(AR)是大部分非大汗腺分化的三阴型乳腺癌(NA—TNC)所不具有的特征。因此AR可作为乳腺大汗腺癌的一个关键诊断标记及治疗靶点。 | Mills A M E Gottlieb C M Wendorth S 王婷 余英豪 | 2016 | 临床与实验病理学杂志2016，32，11： | 10 |
| 2 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 3 | 终末期肾病患者大血管和微血管内皮功能障碍与亚临床心功能不全的关系显示文摘终末期肾病(end-stagerenaldisease,ESRD)患者的心脏衰竭和心血管病死亡率较高,而我们对此缺乏深入透彻的了解,是否存在可变因素导致了这些高危患者发生心功能不全。为了评估血管内皮功能能否作为ESRD患者潜在的心功能不全的可变因素,研究人员应用横断面研究在一个控制良好的ESRD队列中,分析大血管和微血管功能障碍与左、右心功能不全的相关性。 | 刘莉 叶鹏 Dubin RF Guajardo I Ayer A Mills C Donovan C Beussink L Scherzer R Ganz P Shah SJ | 2016 | 中华高血压杂志2016，24，9： | 5 |
| 4 | Preventing infective complications in inflammatory bowel disease显示文摘Over the past decade there has been a dramatic change in the treatment of patients with Crohn’s disease and ulcerative colitis,which comprise the inflammatory bowel diseases(IBD).This is due to the increasing use of immunosuppressives and in particular the biological agents,which are being used earlier in the course of disease,and for longer durations,as these therapies result in better clinical outcomes for patients.This,however,has the potential to increase the risk of opportunistic and serious infections in these patients,most of which are preventable.Much like the risk for potential malignancy resulting from the use of these therapies long-term,a balance needs to be struck between medication use to control the disease with minimization of the risk of an opportunistic infection.This outcome is achieved by the physician’s tailored use of justified therapies,and the patients’education and actions to minimize infection risk.The purpose of this review is to explore the evidence and guidelines available to all physicians managing patients with IBD using immunomodulating agents and to aid in the prevention of opportunistic infections. | Justine Mill Ian C Lawrance | 2014 | World Journal of Gastroenterology2014，20，29： | 4 |
| 5 | Unintended targeting of Dmp1-Cre reveals a critical role for Bmpr1a signaling in the gastrointestinal mesenchyme of adult mice显示文摘Cre/lox P technology has been widely used to study cell type-specific functions of genes. Proper interpretation of such data critically depends on a clear understanding of the tissue specificity of Cre expression. The Dmp1-Cre mouse, expressing Cre from a 14-kb DNA fragment of the mouse Dmp1 gene, has become a common tool for studying gene function in osteocytes, but the presumed cell specificity is yet to be fully established. By using the Ai9 reporter line that expresses a red fluorescent protein upon Cre recombination, we find that in2-month-old mice, Dmp1-Cre targets not only osteocytes within the bone matrix but also osteoblasts on the bone surface and preosteoblasts at the metaphyseal chondro-osseous junction. In the bone marrow, Cre activity is evident in certain stromal cells adjacent to the blood vessels, but not in adipocytes. Outside the skeleton, Dmp1-Cre marks not only the skeletal muscle fibers, certain cells in the cerebellum and the hindbrain but also gastric and intestinal mesenchymal cells that express Pdgfra. Confirming the utility of Dmp1-Cre in the gastrointestinal mesenchyme, deletion of Bmpr1 a with Dmp1-Cre causes numerous large polyps along the gastrointestinal tract, consistent with prior work involving inhibition of BMP signaling.Thus, caution needs to be exercised when using Dmp1-Cre because it targets not only the osteoblast lineage at an earlier stage than previously appreciated, but also a number of non-skeletal cell types. | Joohyun Lim Joseph Burclaff Guangxu He Jason C Mills Fanxin Long | 2017 | Bone Research2017，5，1： | 4 |
| 6 | Twenty-five years of research on the effects of exercise training in breast cancer survivors:A systematic review of the literature显示文摘AIM:To investigate the role of exercise training the past 25 years on major physiological-psychological outcomes studied thus far in this patient population.METHODS:Pub Med, Medline Plus, the Cochrane Library, Web of Science, SportD iscus, Embase, Scorpus, and Google Scholar were searched from September to November 2013 to identify exercise training studies that used objective measurements of fitness and/or patient reported outcomes assessed pre and post-exercise training with statistical analyses performed in at least one of the following outcome measurements:Cardiorespiratory function, body composition, muscular strength, fatigue, depression, and overall quality of life. Five reviewers independently identified the studies that met the criteria for the review and discrepancies were resolved by consensus among all authors.RESULTS:Fifty-one studies were included in this review with 5 from the period between 1989-1999, 11 from 2000-2006, and 35 from 2007-2013. The evolution of study designs changed from aerobic only exercise training interventions(1989-1999), to a combination of aerobic and resistance training(2000-2006), to studies including an arm of resistance training or examining the effects of resistance training as the main mode of exercise(2007-2013). Overall, the benefits of exercise showed improvements in cardiorespiratory function, body composition, strength, and patient reported outcomes including fatigue, depression, and quality of life.CONCLUSION:Exercise training appears to be safe for most breast cancer patients and improvements in physiological, psychological, and functional parameters can be attained with regular participation in moderate intensity exercise. | Claudio L Battaglini Robert C Mills Brett L Phillips Jordan T Lee Christina E Story Marcelo GB Nascimento Anthony Carl Hackney | 2014 | World Journal of Clinical Oncology2014，5，2： | 3 |
| 7 | Folate and vitamin B12 in idiopathic male infertility显示文摘尽管 methylenetetrahydrofolate reductase,叶酸的酶基因,与自发的男不孕被联系了,很少研究检验了另外的叶酸相关的代谢物和基因。我们调查了自发的男不孕是否与变体被联系在叶酸,维生素 B 12(B12 ) 和全部的 homocysteine (tHcy ) 联系了基因并且在血测量了这些代谢物。我们进行了与自发的不孕和在生育力中心和胎儿的照顾中心招募的 184 肥沃的男控制包括了 153 个人的盒子控制研究,大学医院, Malmö并且 Lund,瑞典。浆液叶酸的、红房间叶酸(RCF ) ,浆液 B12,血浆 tHcy 和精液质量被测量。题目是为在与 folate/B12/homocysteine 新陈代谢有关的 12 基因的 20 普通变体的 genotyped。代谢物集中和遗传型分布为 covariates 与调整用线性、逻辑的回归在案例和控制之间被作比较。phosphatidylethanolamine N-methyltransferase (PEMT ) M175V 和 TCblR rs173665 多型性显著地与不孕被联系(P=0.01 和 P=0.009,分别地) ,然而并非与精液质量。在补充的非用户之中,有的不肥沃的人降低浆液叶酸的集中比肥沃的人(12.89 对 14.73 nmol l −1 ;P=0.02 ) ,但是在 RCF, B12 或 tHcy 没有重要差别。叶酸, B12 和 tHcy 集中没与任何精液参数被相关。这研究几乎不提供小支持为低叶酸或在自发的男不孕的致病的 B12 地位。尽管另外的数据被需要证实这些起始的调查结果,我们的结果建议那 PEMT 和 TCblR,基因在胆碱和 B12 新陈代谢包含了,在自发的男不孕应得进一步的调查。 | Laurel E Murphy James L Mills Anne M Molloy Cong Qian Tonia C Carter Helena Strevens Dag Wide-Swensson Aleksander Giwercman Richard J Levine | 2011 | Asian Journal of Andrology2011，13，6： | 2 |
| 8 | HPV E6/E7 mRNA原位杂交诊断宫颈低级别鳞状上皮内病变显示文摘宫颈低级别鳞状上皮内病变(LSIL)[亦称宫颈上皮内瘤变,1级(CIN1)]可带来相当大的诊断挑战,并且与观察者之间重复性较差和过诊断有关。此外,一些辅助性检测项目,如p16免疫组化检查在解析LSIL与正常/反应性鳞状上皮病变的差异作用不大。人类乳头状瘤病毒(HPV)RNA原位杂交(ISH)检测在LSIL的诊断中可能是一种较好的辅助诊断方法,但目前这方面尚没有较大宗病例的研究。 | 解建军 张仁亚 Mills A M Coppock J D Willis B C | 2018 | 临床与实验病理学杂志2018，34，11： | 2 |
| 9 | A new approach for filtering noise from high - density oligonucleotide microarray datasets显示文摘 | MILLS J C GORDON J I | 2001 | Nucleic Acids Res2001，29，： | 2 |
| 10 | 乳腺癌错配修复缺陷与PD-L1表达的关系显示文摘错配修复(MMR)缺陷最近被认为与PD-1/PD-L1免疫抑制疗法的敏感性有关。有研究证明,MMR蛋白缺失表达与直肠癌子宫内膜癌肿瘤组织中PDL-1表达存在一定的联系,但在乳腺癌中MMR蛋白与PD-L1表达之间的关系目前尚未见报道,因为乳腺癌中MMR表达缺失较少见。 | Mills A M Dill E A Moskaluk C A 卢菊萍(摘译) 余英豪(审校) | 2019 | 临床与实验病理学杂志2019，35，3： | 2 |
| 11 | A proposal for an international nomenclature of races of Phytophthora infestans and of genes controlling immunity in Solanum demissum derivaties 显示文摘 | Black W Mastenbrock C Mills W R | 1953 | Enphytica1953，2，3： | 1 |
| 12 | Biochemical Interactions of Food-Derived Peptides 显示文摘 | Mills E N C | 1992 | Trends in Food Science & Technology1992，3，： | 1 |
| 13 | Ralstonia solanacearum extracellularpolysaccharide is a specific elicitor of defense responses in wilt-resistant tomato plants 显示文摘 | Milling A Babujee L Allen C | 2011 | PLoS ONE2011，6，1： | 1 |
| 14 | In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002) 显示文摘 | Hu L Zaloudek C Mills GB | 2000 | Clin Cancer Res2000，6，3： | 1 |
| 15 | Fully human antibodies to MCAM/ MUC18 inhibit tumor growth and metastasis of human melanoma显示文摘 | Mills L Tellez C Huang S | | 0，，17： | 1 |
| 16 | SNS-595, a naphthyridine cell cycle inhibitor and stimulator of apoptosis for the treatment of cancers显示文摘 | Mills D A Fekrazad H M Verschraegen C F | 2008 | Current Opinion in Investigational Drugs2008，9，6： | 1 |
| 17 | Predictions of potential human health and ecological risk from power plant discharges of total residual chlorine and chloroform into rivers 显示文摘 | MILLS W B LEW C S LOH J Y | 1998 | Environ Sci Technol1998，32，14： | 1 |
| 18 | Performance and Properties of Mould Fluxes显示文摘 | Mills K C Fox A B Li Z | 2005 | Ironmaking Steelmaking2005，32，1： | 1 |
| 19 | Surface cracking in continuously cast products显示文摘 | Billany T J H Normanton A S Mills K C | 1991 | Ironmaking and Steelmaking1991，，6： | 1 |
| 20 | Multi-sensor information fusion for targed detection and classification显示文摘 | Roggerman M C Mills J P Rogers S K | 1988 | SPIE1988，931，： | 1 |
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