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| 1 | Transcranial Direct Current Stimulation in ADHD:A Systematic Review of Efficacy,Safety,and Protocol-induced Electrical Field Modeling Results显示文摘Transcranial direct current stimulation(tDCS)is a promising method for altering cortical excitability with clinical implications.It has been increasingly used in neurodevelopmental disorders,especially attention-deficit hyperactivity disorder(ADHD),but its efficacy(based on effect size calculations),safety,and stimulation parameters have not been systematically examined.In this systematic review,we aimed to(1)explore the effectiveness of tDCS on the clinical symptoms and neuropsychological deficits of ADHD patients,(2)evaluate the safety of tDCS application,especially in children with ADHD,(3)model the electrical field intensity in the target regions based on the commonly-applied and effective versus less-effective protocols,and(4)discuss and propose advanced tDCS parameters.Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses approach,a literature search identified 14 empirical experiments investigating tDCS effects in ADHD.Partial improving effects of tDCS on cognitive deficits(response inhibition,working memory,attention,and cognitive flexibility)or clinical symptoms(e.g.,impulsivity and inattention)are reported in10 studies.No serious adverse effects are reported in 747 sessions of tDCS.The left and right dorsolateral prefrontal cortex are the regions most often targeted,and anodal tDCS the protocol most often applied.An intensity of 2 mA induced stronger electrical fields than 1 mA in adults with ADHD and was associated with significant behavioral changes.In ADHD children,however,the electrical field induced by 1 mA,which is likely larger than the electrical field induced by 1 mA in adults due to the smaller head size of children,was sufficient to result in significant behavioral change.Overall,tDCS seems to be a promising method for improving ADHD deficits.However,the clinical utility of tDCS in ADHD cannot yet be concluded and requires further systematic investigation in larger sample sizes.Cortical regions involved in ADHD pathophysiology,stimulation parameters(e.g.intensity,duration,polarity,and electrode size),and types of symptom/deficit are potential determinants of tDCS efficacy in ADHD.Developmental aspects of tDCS in childhood ADHD should be considered as well. | Mohammad Ali Salehinejad Vahid Nejati Mohsen Mosayebi-Samani Ali Mohammadi Miles Wischnewski Min-Fang Kuo Alessio Avenanti Carmelo M・Vicario Michael A.Nitsche | 2020 | Neuroscience Bulletin2020，36，10： | 3 |
| 2 | TORSIONAL AND BENDING VIBRATION MEASUREMENT ON ROTORS USING LASER TECHNOLOGY显示文摘 | T.J MILES M LUCAS N.A HALLIWELL S.J ROTHBERG | 1999 | Journal of Sound and Vibration1999，，3： | 2 |
| 3 | Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford显示文摘BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)patients.AIM To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving remission.METHODS A retrospective review of Australian and Oxford,United Kingdom data for UC patients.Clinical response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were assessed.Cox regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing them.Safety outcomes were recorded.RESULTS Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were included.The clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo respectively.Anti-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 mo.CONCLUSION VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome. | Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara Mogilevski Peter De Cruz Graham Radford-Smith Emma Flanagan Sally Bell Soleiman Kashkooli Miles Sparrow Simon Ghaly Peter Bampton Elise Sawyer Susan Connor Quart-ul-ain Rizvi Jane M Andrews Gillian Mahy Paola Chivers Simon Travis Ian Craig Lawrance | 2020 | World Journal of Gastroenterology2020，26，30： | 2 |
| 4 | Polyconal antibodies to domoic acid, and their use in immunoassays for do moic acid in sea water and shellfish显示文摘 | GARTHWAITE I ROES K M MILES C O | 1998 | Nat Toxins1998，6，： | 1 |
| 5 | Recovery of nerve conduction following microvascular ecompression for trigeminal neuralgia 显示文摘 | Leandri M Eldridge P Miles J | 1998 | Neurology1998，51，6： | 1 |
| 6 | Combustion-properties of biomass 显示文摘 | Jenkins B M Baxter L L Miles T R | 1998 | Fuel Processing Technology1998，54，： | 1 |
| 7 | CT staging of renal carcinoma:a prospective comparison of three dynamic computed tomography techniques显示文摘 | Miles K A London N J M Lavelle J M | 1991 | Eur J Radiol1991，13，7： | 1 |
| 8 | Experimental investigations of ligamentous healing 显示文摘 | Clayton ML Miles JS Abdulla M | 1968 | Clin Orthop Relat Res1968，61，： | 1 |
| 9 | Colour perfusion imaging: A new application of computed tomography显示文摘 | Miles KA Hayball M Dixon AK | 1991 | Lancet1991，337，8742： | 1 |
| 10 | The effects of high-air velocity on broiler performance 显示文摘 | SIMMONS J D LOTT B D MILES D M | 2003 | Poultry Science2003，82，2： | 1 |
| 11 | HPLC analysis of reduced and oxidized coenzyme QlO in plasma by a single dilution step 显示文摘 | TANG H R MILES V M DEGRAUW A | 2001 | Clin Chern2001，47，： | 1 |
| 12 | Pediatric diffuse large B - cell lymphoma demonstrates a high proliferation index, frequent c - Myc protein expression, and a high incidence of germinal center subtype: Report of the French - American - British ( FAB ) international study group 显示文摘 | Miles RR Raphael M McCarthy K | 2008 | Pediatr Blood Cancer2008，51，3： | 1 |
| 13 | Coenzyme QIO ehanges-are associated with metabolic syndrome显示文摘 | Miles M V Morrison J A Horn P S | 2004 | Clinica Chimica Acta2004，344，12： | 1 |
| 14 | Perfusion C T: a worthwhile enhance- ment 显示文摘 | Miles K A Griffiths M R | 2003 | Br J Radio12003，76，904： | 1 |
| 15 | Currency Substitution, Flexible Exchange Rates, and Monetary Independence 显示文摘 | MILES M A | 1978 | American Economic Re- view1978，68，5： | 1 |
| 16 | Perfusion CT: a worthwhile enhancement显示文摘 | Miles K A Griffiths M R | 2003 | Br J Radiol2003，76，2： | 1 |
| 17 | The Evolution and Development of Entrepreneurial Marketing显示文摘 | HILLS G E HULTMAN C M MILES M P | 2008 | Journal of SmallBusiness Management2008，46，1： | 1 |
| 18 | Combi- nation slralegy targeling VEGF and HGF/e-met in human renal cell carcinoma models显示文摘 | CIAMPORCERO E MILES K M ADELAIYE R | 2015 | Mol Cancer Ther2015，14，1： | 1 |
| 19 | Photovoltaie solar cells : an overview of state-of-the-art cell development and environmental issues 显示文摘 | MILES R W HYNES K M FORBES I | 2005 | Progress in Crystal Growth and Characterization of Materials2005，51，13： | 1 |
| 20 | Co lour perfusion imaging: a new application of computed tomography 显示文摘 | Miles KA Hayball M Dixion AK | 1991 | Lancet1991，337，8742： | 1 |
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