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| 1 | 骨折相关性感染定义的共识显示文摘骨折相关性感染(fracture related infection,FRI)是创伤骨科一种常见的严重并发症.迄今为止,尚无明确定义,因此很难对该并发症带来的影响进行准确评估和对现有的研究展开比较.为解决这一难题,在AO基金会的支持下,我们成立了一个由科学家和医学专家组成的专家组,旨在对FRI定义达成的共识. | Metsemakers WJ Morgenstern M McNally MA Moriarty TF McFadyen I Scarborough M Athanasou NA Ochsner PE Kuehl R Raschke M Borens O 谢肇 Velkes S Hungerer S Kates SL Zalavras C Giannoudis PV Richard RG Verhofstad MH 喻胜鹏 孙东 汪小华 | 2018 | 中华骨科杂志2018，38，9： | 8 |
| 2 | Antioxidative and anti-endotoxin effects of propofol on endothelial cells显示文摘Objective To investigate the antioxidant and anti-endotoxin effects of propofol on endothelial cells and the possible mechanisms.Methods Cultured endothelial cells were treated with hydrogen peroxide (H 2O 2), propofol + H 2O 2, lipopolysaccharide (LPS) and propofol + LPS, respectively. Endothelial cell damage was monitored for possible lactic dehydrogenase (LDH) release. The transcription and the protein expression levels of endothelial nitric oxide synthase (eNOS) were measured.Results LDH release was higher in groups treated with H 2O 2 or LPS than in the control group. After pretreatment with propofol, the effects induced by H 2O 2 were attenuated, but propofol did not decrease the LDH release induced by LPS. Both H 2O 2 and LPS significantly increased the eNOS transcript levels and the increases were significantly attenuated after pretreatment with propofol. Both H 2O 2 and LPS significantly increased the eNOS protein expression and the increase was attenuated after pretreatment with propofol. Conclusion Propofol could protect endothelial cells against oxidative stress by inhibiting eNOS transcription and protein expression, but could not antagonise endotoxin induced cell injuries. | 彭志勇 罗敏 叶仕桥 Critchley Lester AH Joynt Gavin M Ho Anthony MH 姚尚龙 | 2003 | Chinese Medical Journal2003，，5： | 7 |
| 3 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial显示文摘 | Pierre J Guillou Philip Quirke Helen Thorpe Joanne Walker David G Jayne Adrian MH Smith Richard M Heath Julia M Brown | 2005 | The Lancet . 2005 (9472)2005，，9472： | 6 |
| 4 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial显示文摘 | Pierre J Guillou Philip Quirke Helen Thorpe Joanne Walker David G Jayne Adrian MH Smith Richard M Heath Julia M Brown | 2005 | The Lancet2005，，9472： | 4 |
| 5 | Antimicrobial Agents from Selected Medicinal Plants in Libya显示文摘Objective:To test the in vitro antimicrobial efficacy of water and methanol extracts of 23 plan species that are commonly used in Libyan folk medicine.Methods:The antimicrobial activity was determinec using the well-diffusion method.Four test microorganisms were used namely,Escherichia coli,Salmonella species,Staphylococcus aureus and Bacillus subtilis.The minimum inhibitory concentration(MIC) was determined for the high biologically active crude plant extracts.Results:Among 23 medicinal plants used in the study,only 5 methanolic extracts[Rosmarinus offcinalis L,Carduus marianium L.,Lantana camara L.,Rhus tripartite(ueria) Grande,and Thymus capitatus(L.) Hoffm(link)]showed the highest antimicrobial activity againsl Staphylococcus aureus,Bacillus subtilis and Salmonella species,while 22 methanolic and aqueous extracts showed moderate to weak antimicrobial activity on all tested organisms.However 19 of the extracts showed no activity at all against Gram-ve and Gram +ve microorganisms.MIC was found to be 1.25 mg/mL(Thymus capitatus),3 mg/mL(Rhus tripartite),4 mg/mL(Carduus marianium),5 mg/mL(Rosamarinus officinalis) and5 mg/mL(Lantana camara),respectively.Conclnsions:The present results revealed that,crude methanolic extracts of the investigated Libyan folk medicinal plants exhibited mild to high in vitro antibacterial activities against Gram-positive and Gram-negative microorganisms. | Hasan MH Muhaisen Miftah Mailoud Ab-Mous Fadel A Ddeeb Aboclaid All Rtemi Omer M Taba Mehtab Parveen | 2016 | Chinese Journal of Integrative Medicine2016，22，3： | 2 |
| 6 | Effect of copper tube casing on strain distribution and mechanical properties of Al-7075 alloy processed by equal channel angular pressing显示文摘 | MH Shaeri F Djavanroodi M Sedighi S Ahmadi MT Salehi SH Seyyedein | 2013 | The Journal of Strain Analysis for Engineering Design2013，，8： | 2 |
| 7 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial显示文摘 | Pierre J Guillou Philip Quirke Helen Thorpe Joanne Walker David G Jayne Adrian MH Smith Richard M Heath Julia M Brown | 2005 | 2005 (9472)2005，，9472： | 2 |
| 8 | 年龄和靶器官损害对24h动态血压预后价值的影响显示文摘靶器官损害标志物和测量24h动态血压可以改善心血管风险分层。随着年龄的增长,靶器官损害和血压升高的发病率增加。该研究目的是评估年龄和靶器官损害对动态血压预测预后价值的影响。 | 黄洁 叶鹏 Olesen TB Stidsen JV Blicher MK Pareek M Rasmussen S Vishram-Nielsen JKK Olsen MH | 2017 | 中华高血压杂志2017，25，10： | 2 |
| 9 | Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial显示文摘 | Pierre J Guillou Philip Quirke Helen Thorpe Joanne Walker David G Jayne Adrian MH Smith Richard M Heath Julia M Brown | 2005 | The Lancet2005，，9472： | 2 |
| 10 | Pit-and trench-forming osteoclasts:a distinction that matters显示文摘Osteoclasts(OCs)seeded on bone slices either drill round pits or dig long trenches.Whereas pits correspond to intermittent resorption,trenches correspond to continuous and faster resorption and require a distinct assembly of the resorption apparatus.It is unknown whether the distinction between pits and trenches has any biological relevance.Using OCs prepared from different blood donors,we found that female OCs achieved increased resorption mainly through pit formation,whereas male OCs did so through trench formation.Trench formation went along with high collagenolytic activity and high cathepsin K(CatK)expression,thereby allowing deeper demineralization.A specific CatK inhibitor abrogated the generation of trenches,while still allowing the generation of pits.OCs obtained from bone marrow were more prone to generate trenches than those obtained from blood.Scanning electron microscopy of bone surfaces eroded in vivo showed trenches and pits of similar size as those made by OCs in culture.We conclude that the distinction between trench-and pit-forming OCs is relevant to the differences among OCs from different skeletal sites,different individuals,including gender,and results from differences in colIagenolytic power.This indicates a biological relevance and highlights the importance of discriminating between pits and trenches when assessing resorption. | Ditte MH Merrild Dinisha C Pirapaharan Christina M Andreasen Per Kjxrsgaard-Andersen Anas MJ Mùller Ming Ding Jean-Marie Delaissé Kent Sùe | 2015 | Bone Research2015，3，4： | 2 |
| 11 | Prognostic Value of Promoter Hypermethylation of Retinoic Acid Receptor Beta (RARB) and CDKN2 (p16/MTS1) in Prostate Cancer显示文摘Objective: The molecular mechanism of prostate cancer is poorly understood. The aim of the study was to investigate the prevalence and prognostic value of promoter hypermethylation of retinoic acid receptor beta (RARB) and p16 among benign prostatic hyperplasia (BPH) and prostate cancer patients. Methods: In this case-control study, 63 patients were included in three groups; 21 with BPH as the control group, 21 with prostate cancer and good prognostic factors (based on prostate-specific antigen, Gleason score and stage) as good prognosis group, and 21 with prostate cancer and poor prognostic features as poor prognosis group. The prostate biopsy specimen of each individual was examined for hypermethylation of RARB and p16 promoters by methylation specific PCR (MSPCR). Results: Seven (33.3%) patients with good prognosis and 15 (71.4%) patients with poor prognosis were positive for RARB methylation, which were significantly higher than controls (P <0.0001). p16 promoter methylation was shown in 19.0% and 47.6% patients with good and poor prognosis, respectively. The RARB and p16 promoter methylation in the poor prognosis group was significantly higher than that in the good prognosis group (P =0.02 for RARB and P<0.0001 for p16). Conclusion: Hypermethylation of RARB and p16 promoters may predict prognosis in prostate cancer. | Ameri A Alidoosti A Hosseini Y Parvin M Emranpour MH Taslimi F Salehi E Fadavi P | 2011 | Chinese Journal of Cancer Research2011，23，4： | 2 |
| 12 | Laser Doppler velocimeter based on the self-mixing effect in a fiber-coupled semiconductor laser:theory显示文摘 | MH Koelink M Slot FFM de Mul | 1992 | Applied Optics1992，31，18： | 1 |
| 13 | Acute and chronic hepatitis:Working Group Report of the First World Congress of pediatric Gastroenterology,Hepatology and Nutrition显示文摘 | Balistreri WF Chang MH Ciocca M | 2002 | Journal of Pediatric Gastroenterology and Nutrition2002，35，2： | 1 |
| 14 | Deep inferior epigastric perforator flap in breast reconstruction: experience with the first 50 flaps显示文摘 | Hamdi M Weiler-Mithoff EM Webster MH | 1999 | Plast Reconstr Surg1999，103，： | 1 |
| 15 | Morphological identification of cell death in dorsal root ganglion neurons following peripheral nerve injury and repair in adult rat显示文摘 | Atlasi MA Mehdizadeh M Bahadori MH | 2009 | Iranlan biomedical2009，13，2： | 1 |
| 16 | Abdominal sacrohysteropexy for uterovaginal prolapse:a prospective study on 33 cases显示文摘 | FADY M MOIETY S HASSAN MH | 2010 | ARCHIVES of Gynecology and Obstetvics2010，281，4： | 1 |
| 17 | An epidemiology study of oral clefts in Iran:analysis of 1669 cases显示文摘 | Rajabian MH Sherkat M | 2000 | Cleft Palate Craniofac J2000，37，2： | 1 |
| 18 | Effect of milrinone on short - term outcome of patients with myocardial dysfunction un der going coronary artery bypass graft: A randomized controlled trial显示文摘 | Jebeli M Ghazinoor M Mandegar MH | 2010 | Cardinl J2010，，1： | 1 |
| 19 | Comparison of the immu-nogenicity and safety of Cervarix and Gardasil human papilloma-virus(HPV)cervical cancer vaccines in health women aged 18-45 years显示文摘 | Einstein MH Baron M Levin MJ | 2009 | Hum Vaccin2009，5，10： | 1 |
| 20 | Grafts of genetically modified schwann cells to the spinal cord: survival, axon growth, and myelination显示文摘 | Tuszynski MH Weidner N McCormack M | 1998 | Cell Transplant1998，7，2： | 1 |
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