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| 1 | 不同地域患者罗库溴铵药效学的比较——多中心研究显示文摘目的比较中国、奥地利和美国3个不同地域的当地患者罗库溴铵作用的量效关系和时效关系。方法选择中国大连、美国英格伍德、奥地利格拉茨3个医学中心择期手术患者各18例,异丙酚、芬太尼静脉麻醉诱导后,累积剂量法进行药效学观察,首剂静脉注射罗库溴铵50μg/kg,起效后重复首剂静脉给药6次,再静脉注射罗库溴铵300μg,采用肌机械运动监测仪记录肌肉收缩强度,对数剂量.概率单位绘制剂量-反应曲线。比较3个地域患者罗库溴铵的ED50、ED90和ED95以及Dur25和Dur0.8。结果大连和格拉茨患者罗库溴铵的ED50、ED90和ED95均高于英格伍德患者,格拉茨患者的ED50、ED90和ED95高于大连患者(P<0.05);大连和格拉茨患者的Dur25和Dur0.8均短于英格伍德患者(P<0.05),格拉茨患者的Dur25短于大连患者(P<0.05),但两者Dur0.8的差异无统计学意义(P>0.05)。结论3个地域患者罗库溴铵作用的量效关系和时效关系有明显的差别,临床用量需要考虑地域因素的影响。 | 安刚 肖昭扬 李宝珠 黄磷 魏芳 Ashnaf A. Dahaba Henry Bennett Aryeh Shander Helfried Metzler Peter H. Rehak | 2007 | 中华麻醉学杂志2007，27，3： | 7 |
| 2 | The random walk’s guide to anomalous diffusion: a fractional dynamics approach显示文摘 | Ralf Metzler Joseph Klafter | 2000 | Physics Reports2000，，1： | 3 |
| 3 | Fluoroscopically Guided Nasoenteric Feeding Tube Placement Versus Bedside Placement显示文摘 | ALAN E. HILLARD JOHN J. WADDELL MICHAEL H. METZLER DIANE McALPIN | 1995 | Southern Medical Journal1995，，4： | 2 |
| 4 | Elevated relapse rate under oral methotrexate versus leflunomide for maintenance of remission in Wegener's granulomatosis显示文摘 | Metzler C Miehle N Manger K | 2007 | Rheumatology ( Oxford )2007，46，7： | 1 |
| 5 | Microstrip Series Arrays 显示文摘 | Metzler | 1981 | IEEE Trans on AP1981，29，1： | 1 |
| 6 | Physical pictures of transport in heterogeneous media:Advection-dispersion,random-walk and fractional derivative formulations显示文摘 | Berkowitz B Klafter J and Metzler R | 2002 | Water Resources Research2002，38，10： | 1 |
| 7 | Strategic gaming analysis for electric power systems:an MPEC approach显示文摘 | Hobbs B F Metzler C B Pang J S | 2000 | IEEE Transactions on Power Systems2000，15，2： | 1 |
| 8 | Churg Strauss syndrome--successful induction of remission with methotrexate and unexpected high cardiac and pulmonary relapse ratio during maintenance treatment显示文摘 | Metzler C Hellmich B Gause A | 2004 | Clin Exp Rheumatol2004，22，636： | 1 |
| 9 | Electrostatic enhancement of the dust separation in a nozzle scrubber 显示文摘 | Metzler P Weib P Uttner H B | 1997 | Electrostatic1997，42，12： | 1 |
| 10 | High expression of precursor microRNA-155/BIC RNA in children with Bnrkitt lymphoma显示文摘 | Metzler M Wilda M Busch K | 2004 | Genes Chromosome Cancer2004，39，2： | 1 |
| 11 | Th17cells,not IL-17+γδT cells,drive arthritic bone destruction in mice and humans显示文摘 | P llinger B Junt T Metzler B | 2011 | J Immunol2011，186，4： | 1 |
| 12 | HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis 显示文摘 | Singaraja R R Hadano S Metzler M | 2002 | Hum Mol Genet2002，11，23： | 1 |
| 13 | Maintenance of remission with leflunomide in Wegener's granulomatosis显示文摘 | Metzler C Fink C Lamprecht P | 2004 | Rheumatology(Oxford)2004，43，3： | 1 |
| 14 | A randomized, pharmacokinetic and pharmacodynamic, cross-over study of duodenal or jejunal administration compared to nasogastric administration of omeprazole suspension in patients at risk for stress ulcers显示文摘 | Jeffrey O Phillips Keith M Olsen Jill A Rebuck Nick J Rangnekar Brent W Miedema Michael H Metzler | 2001 | The American Journal of Gastroenterology2001，，： | 1 |
| 15 | Canine distemper virus-associated cardial necrosis in the dog显示文摘 | Higgins R J Krakowka S Metzler A E | 1981 | Vet Pathol1981，18，： | 1 |
| 16 | HIP1 functions in clath- tin-mediated endocytosis through binding to clathrin and adaptor protein 2显示文摘 | Metzler M Legendre-Guillemin V Gan L | 2001 | J Biol Chem2001，276，39： | 1 |
| 17 | Primary demyelination in experimental canine distemper virus induced encephalomye litis in gnotobiotic dogs显示文摘 | HIGGINS R J KRAKOWKA S G METZLER A E | 1982 | Acta Neuropathologica1982，，58： | 1 |
| 18 | Mental rotation of three-dimensional ob- jects 显示文摘 | Shepard RN Metzler J | 1971 | Science1971，171，3972： | 1 |
| 19 | Establishment of a streptozotocin-induced diabetic domestic pig model and a systematic evaluation of pathological changes in the hard and soft tissue over a 12-month period显示文摘 | Von Wilmowsky C Stockmann P Metzler P | | 0，，07： | 1 |
| 20 | Elevated relapse rate under oral methotrexate versus leflunomide for maintenance of remission in Wegener's granulomatosis显示文摘 | Metzler C Miehle N Manger K | 2007 | Rheumatology(Oxford)2007，46，7： | 1 |
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