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| 1 | Activation of microbial secondary metabolic pathways:Avenues and challenges显示文摘Microbial natural products are a tremendous source of new bioactive chemical entities for drug discovery.Next generation sequencing has revealed an unprecedented genomic potential for production of secondary metabolites by diverse micro-organisms found in the environment and in the microbiota.Genome mining has further led to the discovery of numerous uncharacterized‘cryptic’metabolic pathways in the classical producers of natural products such as Actinobacteria and fungi.These biosynthetic gene clusters may code for improved biologically active metabolites,but harnessing the full genetic potential has been hindered by the observation that many of the pathways are‘silent’under laboratory conditions.Here we provide an overview of the various biotechnological methodologies,which can be divided to pleiotropic,biosynthetic gene cluster specific,and targeted genome-wide approaches that have been developed for the awakening of microbial secondary metabolic pathways. | Bikash Baral Amir Akhgari Mikko Metsä-Ketelä | 2018 | Synthetic and Systems Biotechnology2018，3，3： | 4 |
| 2 | Intramolecular Induction of Asymmetric Darzen's Condensation of Aldehydes with Chiral α-Chloroacetates显示文摘The asymmetric Darzen’s condensation of aldehydes with a-chloroacetates of somenaturally occurring or synthetic chiral alcohols was described. The de% of products fell over therange of 4. 78% to 99%. | Guo Bin HUANG Gan Feng CAO Ke Met WU Liang HUANG(Institute of Materia Medica. Chinese Academy of Medical Sciences & Peking Union Medical College.Xian Nong Tan Street. Beijing 100050) | 1999 | Chinese Chemical Letters1999，10，6： | 4 |
| 3 | Pediatric Nd:YAG laser capsulotomy in the operating room: review of 87 cases显示文摘AIM: To report a large series of children having Nd:YAG laser capsulotomy in the operating room using the lateral decubitus position. METHODS: Medical records of children who underwent Nd:YAG laser capsulotomy in the operating room at Ann & Robert H. Lurie Children's Hospital of Chicago between September 2008 and April 2017 were reviewed. Induction of general anesthesia and intubation was performed in the supine position after which the patient was placed in lateral decubitus position. The Nd:YAG laser capsulotomy was performed using a standard protocol. At the completion of the procedure, the patient was turned back into the supine position and extubated. RESULTS: This study included 87 eyes of 60 patients. Patient's age ranged from 1 to 18 y(mean 6.4±4.1 y). In most cases(84/87, 97%), the procedure was performed under general anesthesia. In all cases, good focus on the membrane was achieved, and the procedure was performed successfully. There were no intraoperative ocular or anesthesia-related complications. CONCLUSION: When performing Nd:YAG laser capsulotomy in the operating room, the lateral decubitus position allowsan easy and safe approach without the risk of potentially devastating complications that have been associated with the previously described sitting and prone positions. | Michael Kinori Narasimhan Jagannathan Anne M Langguth Marjorie A Sasso Marilyn B Mets Bahram Rahmani Hawke Yoon Rebecca Mets-Halgrimson Sudhi P Kurup Janice L Zeid | 2019 | International Journal of Ophthalmology(English edition)2019，12，5： | 2 |
| 4 | Condensation Reaction of α-Aroyl-α-acetyl Ketene Cyclic Dithioacetals with Aromatic Aldehydes显示文摘Asaversatilethree-carbonsynthon,a--oxoketenedimethylthioacetalsIhavebeenappliedinmanyfields'''.Inourpreviousworks'-',someproperties,especiallyadditionselectivity,ofthearoxoketenecyclicdithioacetals2werefoundtobequitedifferentfromthoseof1.Herea--aroyl... | Zhong Wei XIE Qun Xin FANG Yu Lan HU Met Xin ZHAO Dong YU Qun LIU(Department of Chemistry, Northeast Normal University, Changchun, 130024) | 1999 | Chinese Chemical Letters1999，10，1： | 2 |
| 5 | A feasible method for fractional snow cover mapping in boreal zone based on a reflectance model显示文摘 | SARI J Mets(a)m(a)ki SAKU T Anttila HUTTUNEN J Markus 2005 | 2005 | Remote Sensing of Environment2005，95，： | 1 |
| 6 | Produc tion and characterization of clinical grade exosomes de- rived from dendritic cells显示文摘 | Lamparski HG Met ha-Damani A Yao JY | 2002 | Immunol Meth2002，270，2： | 1 |
| 7 | The phaxmacokinetics of anesthetic drugs and adjuvants during cardiopulmonary bypass 显示文摘 | Mets B | 2000 | Acta Anaesthesiol Scand2000，44，3： | 1 |
| 8 | The six-minute walk test in community dwelling elderly influence of health status 显示文摘 | BAUTMANS I LAMBERT M METS T | 2004 | BMC Geriatr2004，4，： | 1 |
| 9 | The 6-minute walk as an appropriate exercise test in elderly patients with chronic heart failure 显示文摘 | Mets T | 1996 | Gerontol A Biol Sci Med Sci1996，51，4： | 1 |
| 10 | The 6-minute walk as an appropriate ex- ercise test in elderly patients with chronic heart failure显示文摘 | Peeters P Mets T | 1996 | J Gerontol A Biol Sci Med Sci1996，51，4： | 1 |
| 11 | The pharmacokinetics of anesthetic drugs and adjuvants during cardiopulmonary bypass显示文摘 | Mets B | | 0，，03： | 1 |
| 12 | Haplotype relative risk study of catechol-o-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD):association of the high-enzyme activity Val allele with ADHD impulsive-hyperactive phenotype显示文摘 | Eisenberg J Met TG Steinberg A | 1999 | Am J Med Genet1999，88，5： | 1 |
| 13 | Transient failure to dephosphorylate the cdc2-cyclin B 1 complex accompanies radiation-induced G2-phase arrest in HeLa cells显示文摘 | Metting NF Little JB | 1995 | Radiat Res1995，143，3： | 1 |
| 14 | TRAF6 is a critical signal transducer in IL-33 signaling pathway 显示文摘 | Funakoshi-Tago M Tago K Hayakawa Met cd | 2008 | Cell Signal2008，20，9： | 1 |
| 15 | Binocularity following surgical correction of strabismus in adults显示文摘 | Mets MB Beauchamp C Haldi BA | | 0，，05： | 1 |
| 16 | Subintimal augioplasty for peripheral arterial occlusive disease : a systematic review 显示文摘 | Met R Van Lienden KP Koelemay MJ | 2008 | Cardiovasc lntervent Radiol2008，31，4： | 1 |
| 17 | Significant evidence for linkage of mitesensitive childhood asthma to chromosome 5q31-q33 near the interleukin 12 B locus by a genome-wide search in Japanese families显示文摘 | Yokouchi Y Nukaga Y Shibasaki Met ol | 2000 | Genomics2000，66，2： | 1 |
| 18 | Timing of triggering in relation to the cardiac cycle in nonelite rifle shooters 显示文摘 | Konttinen N Mets T Lyytinen H etal | 2003 | Res Q Exerc Sport2003，74，4： | 1 |
| 19 | Usher Syndrome: Characteristics and Outcomes of Pediatric Cochlear Implant Recipients显示文摘 | Kris R. Jatana Denise Thomas Lisa Weber Marilyn B. Mets Josh B. Silverman Nancy M. Young | 2013 | Otology & Neurotology2013，，3： | 1 |
| 20 | Subintimal Angioplasty for peripheral arterial occlusive disease: a systematic review 显示文摘 | Met R Van Lienden KP Koelemay M J | 2008 | Caidiovasc Intervent Radiol2008，31，4： | 1 |
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