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| 1 | Weight gain following breast cancer diagnosis: Implication and proposed mechanisms显示文摘Weight gain occurs in the majority of women following breast cancer treatment. An overview of studies describing weight gain amongst women treated with early to modern chemotherapy regimens is included. Populations at higher risk include women who are younger, closer to ideal body weight and who have been treated with chemotherapy. Weight gain ranges between 1 to 5 kg, and may be associated with change in body composition with gain in fat mass and loss in lean body mass. Women are unlikely to return to pre-diagnosis weight. Possible mechanisms including inactivity and metabolic changes are explored. Potential interventions are reviewed including exercise, dietary changes andpharmacologic agents. Although breast cancer prognosis does not appear to be significantly impacted, weight gain has negative consequences on quality of life and overall health. Future studies should explore change in body composition, metabolism and insulin resistance. Avoiding weight gain in breast cancer survivors following initial diagnosis and treatment should be encouraged. | Grace Makari-Judson Barry Braun D Joseph Jerry Wilson C Mertens | 2014 | World Journal of Clinical Oncology2014，5，3： | 8 |
| 2 | Bcl-2 degradation is an additional pro-apoptotic effect of polo-like kinase inhibition in cholangiocarcinoma cells显示文摘AIM To examine the influence on apoptotic mechanisms following inhibition of polo-like kinases as therapeuticallyapproach for cholangiocellular cancer treatment. METHODS As most cholangiocarcinomas are chemotherapyresistant due to mechanisms preventing tumor cell death, we investigated the effect of Cisplatin on cholangiocellular carcinoma(CCA) cell lines KMCH-1 and Mz-Ch-1. Polo-like kinases(PLK) are important regulators of the cell cycle and their inhibition is discussed as a potential therapy while PLK inhibition can regulate apoptotic mediators. Here, cells were treated with PLK inhibitor BI6727(Volasertib), Cisplatin, and in combination of both compounds. Cell viability was assessed by MTT; apoptosis was measured by DAPI staining and caspase-3/-7 assay. Western blot and q RT-PCR were used to measure expression levels of apoptosis-related molecules Bax and Bcl-2. RESULTS The cell viability in the CCA cell lines KMCH-1 and Mz-Ch-1 was reduced in all treatment conditions compared to vehicle-treated cells. Co-treatment with BI6727 and cisplatin could even enhance the cytotoxic effect of cisplatin single treatment. Thus, co-treatment of cisplatin with BI6727 could slightly enhance the cytotoxic effect of the cisplatin in both cell lines whereas there was evidence of increased apoptosis induction solely in Mz-Ch-1 as compared to KMCH-1. Moreover, PLK inhibition decreases protein levels of Bcl-2; an effect that can be reversed by the proteasomal degradation inhibitor MG-132. In contrast, protein levels of Bax were not found to be altered by PLK inhibition. These findings indicate that cytotoxic effects of Cisplatin in Mz-Ch-1 cells can be enhanced by co-treatment with BI6727.CONCLUSION In conclusion, BI6727 treatment can sensitize CCA cells to cisplatin-induced apoptosis with proteasomal Bcl-2 degradation as an additional pro-apoptotic effect. | Svenja Sydor Sami Jafoui Lena Wingerter Sandra Swoboda Joachim C Mertens Guido Gerken Ali Canbay Andreas Paul Christian D Fingas | 2017 | World Journal of Gastroenterology2017，23，22： | 5 |
| 3 | Metal uptake by young trees from dredged brackish sediment:Limitations and possibilities for phytoextraction and phytostabilisation显示文摘 | MERTENS J VERVAEKE P SCHRIJVER A D | | Science of the total environ- ment0，326，： | 1 |
| 4 | Developments of Nonthermal Processes for Food Preservation显示文摘 | Mertens B Knorr D | 1992 | Food Technol1992，46，： | 1 |
| 5 | Observations of sexually transmitted disease consultations in India显示文摘 | Mertens TE Smith GD Kantharaj K Mugrditchian D | 1998 | Public Health1998，112，2： | 1 |
| 6 | Selection of phage-displayed peptides recognised by monoclonal antibodies directed against the lipopolysaccharide of Brucella显示文摘 | Walgraffe D Laurent T | 2001 | Int Rev Immunol2001，20，2： | 1 |
| 7 | Simian rotaviruses possess divergent gene constellations that originated from interspecies transmission and reas- sortment 显示文摘 | Matthijnssens J Taraporewala Z F Yang H Rao S Yuan L Cao D Hoshino Y Mertens P P Carner G R McNeal M Sestak K Van Ranst M Patton J T | 2010 | J Virol2010，84，4： | 1 |
| 8 | Five-year re- sults of vitrectomy and silicone oil in patients with prolifera- tive vitreoretinopathy 显示文摘 | van Menrs J C Mertens D A Peperkamp E | 1993 | Retina1993，13，4： | 1 |
| 9 | Ala228 variant of trail receptor 1 affecting the ligand binding site is associated with chronie lymphocytic leukemia, mantle cell lymphoma, prostate cancer, head and neck squamous cell carcinoma and bladder cancer显示文摘 | Wolf S Mertens D Pscherer A | 2006 | Int J Cancer2006，118，7： | 1 |
| 10 | Creating a System for Meeting the Fiber Requirements of Dairy Cows显示文摘 | Mertens D R | 1997 | J Dairy Sci1997，80，： | 1 |
| 11 | Formation of intermetallie cobalt phases in the near surface region of cemented carbides for improved diamond layer deposition显示文摘 | Cremera R Mertens R Neuschutitz D | 1999 | Thin Solid Films1999，，： | 1 |
| 12 | Characterization of the field-saturated hydraulic conductivity on a hillslope:in situ single ring pressure infiltrometer measurements显示文摘 | Mertens J Jacques D Vanderborght J | 2002 | Journal of Hydrology2002，，： | 1 |
| 13 | 显示文摘 | D R J R Loften | 1980 | J Dairy Sci1980，63，9： | 1 |
| 14 | Randomized clinical trial of cryotherapy versus laser photocoagulation for retinopexy in conventional retinal detachment surgery 显示文摘 | Veckeneer M Van Overdam K Bouwens D Feron E Mertens D Peperkamp E | 2001 | Am J Ophthalmol2001，132，3： | 1 |
| 15 | Global histone acetyla- tion levels: prognostic relevance in patients with renal cell carci- noma显示文摘 | Mosashvilli D Kahl P Mertens C | 2010 | Cancer Sci2010，101，12： | 1 |
| 16 | Borate distribution in stabilized stainless steel slag 显示文摘 | Durinck D Arnout S Mertens G | 2008 | Journal of the American Ceramic Society2008，91，2： | 1 |
| 17 | Creating a system for meeting the fiber requirements of dairy cows 显示文摘 | Mertens D L | 1997 | J Dairy Sci1997，80，： | 1 |
| 18 | A qualitative study of the adoption of buprenorphine for opioid addiction treatment显示文摘 | GREEN CA MCCARTY D MERTENS J et d | 2014 | J Subst Abuse Treat2014，46，3： | 1 |
| 19 | From pathogenesis to treat-ment of chronic lymphocytic leukaemia 显示文摘 | Zenz T Mertens D Kuppers R | 2010 | Nat Rev Cancer2010，10，1： | 1 |
| 20 | Creating a system for meeting the fiber requirements of dairy cows显示文摘 | MERTENS D R | 1997 | Journal of Dairy Science1997，80，7： | 1 |
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