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| 1 | Renal function and physical fitness after 12-mo supervised training in kidney transplant recipients显示文摘AIM To evaluate the effect of a 12-mo supervised aerobic and resistance training, on renal function and exercise capacity compared to usual care recommendations.METHODS Ninety-nine kidney transplant recipients(KTRs) were assigned to interventional exercise(Group A; n = 52) and a usual care cohort(Group B; n = 47). Blood and urine chemistry, exercise capacity, muscular strength, anthropometric measures and health-related quality of life(HRQo L) were assessed at baseline, and after 6 and 12 mo. Group A underwent a supervised training three times per week for 12 mo. Group B received only general recommendations about home-based physical activities.RESULTS Eighty-five KTRs completed the study(Group A, n = 44; Group B, n = 41). After 12 mo, renal function remained stable in both groups. Group A significantly increased maximum workload(+13 W, P = 0.0003), V'O2 peak(+3.1 mL/kg per minute, P = 0.0099), muscular strength in plantar flexor(+12 kg, P = 0.0368), height in the countermovement jump(+1.9 cm, P = 0.0293) and decreased in Body Mass Index(-0.5 kg/m^2, P = 0.0013). HRQo L significantly improved in physical function(P = 0.0019), physical-role limitations(P = 0.0321) and social functioning scales(P = 0.0346). Noimprovements were found in Group B.CONCLUSION Twelve-month of supervised aerobic and resistance training improves the physiological variables related to physical fitness and cardiovascular risks without consequences on renal function. Recommendations alone are not sufficient to induce changes in exercise capacity of KTRs. Our study is an example of collaborative working between transplant centres, sports medicine and exercise facilities. | Giulio Sergio Roi Giovanni Mosconi Valentina Totti Maria Laura Angelini Erica Brugin Patrizio Sarto Laura Merlo Sergio Sgarzi Michele Stancari Paola Todeschini Gaetano La Manna Andrea Ermolao Ferdinando Tripi Lucia Andreoli Gianluigi Sella Alberto Anedda Laura Stefani Giorgio Galanti Rocco Di Michele Franco Merni Manuela Trerotola Daniela Storani Alessandro Nanni Costa | 2018 | World Journal of Transplantation2018，8，1： | 4 |
| 2 | A human translational model based on neuroplasticity for pharmacological agents potentially effective in Treatment-Resistant Depression: focus on dopaminergic system显示文摘Major depressive disorder(MDD)is a common psychiatric condition characterized by two main symptoms,low mood and anhedonia.About 15–30%of people suffering from MDD do not respond to standard-of-care antidepressants,e.g.,the serotonin re-uptake inhibitors(SSRI),and are considered affected by Treatment-Resistant Depression(TRD).The neurobiology of this condition is presently unknown.Recent attempts of developing novel treatments for TRD have been driven by four major breakthroughs:(1)Increasing dopaminergic neurotransmission improves TRD symptoms;(2)Anhedonia occurs when central dopaminergic neurotransmission is low;(3)Enhanced neuroplasticity is critical for the action of antidepressants;(4)Ketamine shows antidepressant properties in TRD patients and triggers neuroplasticity in preclinical animal models.These breakthroughs are at the basis of a putative human translational cellular model for antidepressant agents that we are proposing in this article.The rationale is briefly described here. | Ginetta Collo Emilio Merlo Pich | 2020 | Neural Regeneration Research2020，15，6： | 4 |
| 3 | Ketamine enhances structural plasticity in human dopaminergic neurons:possible relevance for treatment-resistant depression显示文摘Depression refers to a series of mental health issues characterized by loss of interest and enjoyment in everyday life,low mood and selected emotional,cognitive,physical and behavioral symptoms.Depression is a common disorder,affecting 5–15%of the general population.When diagnosed as major depressive disorder(MDD),patients are | Ginetta Collo Emilio Merlo Pich | 2018 | Neural Regeneration Research2018，13，4： | 3 |
| 4 | Chemical and spectroscopic characterization of humic substances from sediment and riparian soil of a highly polluted urban river (Suquía River, Cordoba, Argentina)显示文摘The Suquía River,the largest urban river in C ordoba(Argentina),has been severely polluted for decades.Actions must be taken to restore its environmental quality by managing riparian zones for increased water-self purification.The current study aimed to characterize organic matter(OM)dynamics and humic substances(HS)spectrochemical properties along the lower-middle basin of the Suquía River.Riparian soil(0e20 cm)and sediment(0e10 cm)samples were collected from a reference location(S1)and four polluted sites(S2eS5)during a low-flow period.The contents of soil and sedimentary OM and HS fractions were analyzed by wet oxidation,as well as HS Fourier transform infrared(FT-IR)and ultravioletevisible(UVeVis)spectrochemical properties.The OM and HS fractions from riparian soil were high upstream of C ordoba City(S1 and S2,50.2e50.4 g/kg OM)and within a 50 km downstream location(S5,30.9 g/kg OM)owing to a surplus of fresh plant biomass-carbon(C)inputs.Highly heterogeneous sediment samples did not show any significant differences among sites(P>0.05).The lowest values of the ratio of absorbances at 465 and 665 nm(E4/E6)(1.78)and the Δ log K(0.15)coefficient(a measure of HS maturity degree)were obtained downstream of C ordoba City,for both riparian soil and sediment,indicating that HS were enriched by more condensed aromatic structures within highly degraded portions of the river.All samples exhibited similar IR spectra,implying overlapping recalcitrant-C structures at the functional group level,but with different absorbance intensity.Data from the current study constitute a baseline for understanding the chemical nature of HS from sediment and riparian soil along the Suquía River and can be used as a reference for future studies tracking OM compositional changes over time. | Carolina Merlo Carolina Vázquez Ana Graciela Iriarte Carlos Matías Romero | 2020 | International Journal of Sediment Research2020，35，3： | 3 |
| 5 | One Step on the Smart Grid Path: Load and Generation Coordination in a Virtual Power System显示文摘 | E. Cagno F. Castelli Dezza M. Delfanti M. Merlo A. Trianni | 2011 | Journal of Energy and Power Engineering2011，5，3： | 2 |
| 6 | Hypermethylation associated inactivation indicates a tumor suppressor role p15 INK4B显示文摘 | Jen J Merlo A | 1996 | Cancer Res1996，51，4： | 1 |
| 7 | Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF) 显示文摘 | Merlos M Giral M Balsa D | 1997 | The Journal of Phar- macology Experimental Therapeutics1997，280，1： | 1 |
| 8 | Frequency of micronu clei in lymphocytes from a group of floriculturists exposed to pesticides显示文摘 | Bolognesi C Parrini M Merlo F | 1993 | J Toxicol Environ Heahh1993，40，40： | 1 |
| 9 | Inactivation of the CDKN2/ p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers显示文摘 | Herman JG Merlo A Mao L | 1995 | Cancer Res1995，55，20： | 1 |
| 10 | Estrogen activates matrix metallopro-teinases-2 and -9 to increase beta amyloid degradation显示文摘 | Merlo S Sortino MA | 2012 | Mol Cell Neurosci2012，49，4： | 1 |
| 11 | Elevated levels of plasma prekallikrein,high molecular weight kininogen and factorⅪin coronary heart disease显示文摘 | Merlo C Wuillemin WA Redondo M | 2002 | Atherosclerosis2002，161，2： | 1 |
| 12 | Survival after single versus bilateral lung transplantation for high-risk patients with pulmonary fibrosis 显示文摘 | Weiss ES Allen JG Merlo CA | 2009 | Ann Thorac Surg2009，88，5： | 1 |
| 13 | Prevalence of functional gastrointestinal disorders in school-aged children in El Salvador显示文摘 | R. Zablah C.A. Velasco-Benítez I. Merlos S. Bonilla M. Saps | 2015 | Revista de Gastroenterología de México (English E2015，，3： | 1 |
| 14 | Activation of FOXO1 by Cdkl in cycling cells and postmitotic nettrons显示文摘 | Yuan Z Becker EB Merlo P | 2008 | Science2008，319，： | 1 |
| 15 | The relationship between individual creativity and team creativity: aggregating across people and time显示文摘 | Merlo P Mann L | 2004 | Journal of Organizational Behavior2004，25，： | 1 |
| 16 | Rupatadine: a new selective histamine H1 receptor and platelet-activat- ing factor(PAF) antagonist显示文摘 | Izquierdo I Merlos M Garcia-Rafanell JR | 2003 | Drugs of Today2003，39，6： | 1 |
| 17 | Hyperm-ethylation-associated inactivation indicates atumor supperessor role for p15显示文摘 | HERMAN J G JEN J MERLO A | 1996 | Cancer Res1996，56，： | 1 |
| 18 | Binding and functions of extracellular ATP in cultured cerebellar granular neurons显示文摘 | Merlo D and Volonte C | 1996 | Biochem Biophys Res Commun1996，225，3： | 1 |
| 19 | FOXP3 Expression and Overall Survival in Breast Cancer 显示文摘 | Merlo A Casalini P Carcangiu M L | 2009 | J Clin Oncol2009，27，11： | 1 |
| 20 | Frequent co - alteration of TP53, pl6/CDK2A, pl4AR4F, PTEN tumor suppressor gene in human glioma cell lines显示文摘 | Ishii N Maier D Merlo A | 1999 | Brain Pathol1999，9，3： | 1 |
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