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| 1 | Effect of early preoperative 5-fluorouracil on the integrity of colonic anastomoses in rats显示文摘AIM:To determine the effect of chemotherapy on wound healing by giving early preoperative 5-fluorouracil (5-FU)to rats with colonic anastomoses. METHODS:Sixty Albino-Wistar male rats(median weight,235 g)were used in this study.The rats were fed with standard laboratory food and given tap water ad libitum.The animals were divided into three groups: Group 1:Control group(chemotherapy was not administered),Group 2:Intraperitoneally(IP)administered 5-FU group(chemotherapy was administered IP to animals at a dose of 20 mg/kg daily during the 5 d preceeding surgery),Group 3:Intravenously(IV)administered 5-FU group.Chemotherapy was administered via the penil vein,using the same dosing scheme and duration as the second group.After a 3-d rest to minimize the side effects of chemotherapy,both groups underwent surgery.One centimeter of colon was resected 2 cm proximally from the peritoneal reflection,thensutured intermittently and subsequently end-to-end anastomosed.In each group,half the animals were given anaesthesia on the 3rd postoperative(PO)day and the other half on the 7th PO day,for in vivo analytic procedures.The abdominal incisions in the rats were dissected,all the new and old anastomotic segments were clearly seen and bursting pressures of each anastomotic segment,tissue hydroxyproline levels and DNA content were determined to assess the histologic tissue repair process. RESULTS:When the IV group was compared with the IP group,bursting pressures of the anastomotic segments on the 3rd and 7th PO days,were found to be significantly decreased,hydroxyproline levels at the anastomotic segment on the 7th PO day were significantly decreased(P<0.01). CONCLUSION:In this study,we conclude that early preoperative 5-FU,administered IV,negatively affects wound healing.However,IP administered 5-FU does not negatively affect wound healing. | Leyla Ozel M Sefa Ozel Ahmet Burak Toros Melih Kara Kemal Sirri Ozkan Gurkan Tellioglu Osman Krand Meral Koyuturk Ibrahim Berber | 2009 | World Journal of Gastroenterology2009，15，33： | 7 |
| 2 | Thiamin confers enhanced tolerance to oxidative stress in Arabidopsis 显示文摘 | Meral T-O Gad M Luhua S | 2009 | Plant Physiology2009，151，1： | 1 |
| 3 | Thestudy of disorder and nanocrystallinity in C-S-H,sup-plementary cementitious materials and geopolymers u-sing pair distribution function analysis显示文摘 | Meral Cagla Benmore C J Monteiro Paulo J M | 2011 | Cementand Concrete Reseach2011，41，： | 1 |
| 4 | Effects of a GnRH agonist on oocyte number and maturation in mice superovulated with eCG and Hcg显示文摘 | Kanter M Yildiz C Meral I | 2004 | Theriogenology2004，61，： | 1 |
| 5 | Investigation of norovirus infection incidence among 0-5 years old children with acute gastroenteritis admitted to two different hospitals in Ankara, Turkey显示文摘 | Ahay A Bozday G Meral M | 2013 | Mikrobiyol Bul2013，47，1： | 1 |
| 6 | Comparison of the efficacy of nebulised budesonide with parenteral corticosteroids in the treatment of acute exacerbations of chronic obstructive pulmonary disease显示文摘 | Mirici A Meral M Akgun M | 2003 | Clin Drug Invest2003，23，1： | 1 |
| 7 | Two different dosagesof nebulized steroid versus parenteral steroid in the managementof COPD exacerbations: a randomized control trial 显示文摘 | Yilmazel Ucar E Araz 0 Meral M | 2014 | Med SciMonit2014，28，20： | 1 |
| 8 | Comparison of the efficacy of nebulised budesonide with parenteral cortieosteroids in the treatment of acute exacerbations of chronic obstructive pulmonary disease显示文摘 | Mirici A Meral M Akgun M | 2003 | Clin Drug Invest2003，23，1： | 1 |
| 9 | Comparison of the efficacy of nebulised budesonide with parenteral corticosteroids in the treatment of acute exacerbations of chronic obstructive pulmonary disease显示文摘 | Mirici A Meral M Akgun M | 2003 | ClinDruglnvestiq2003，23，1： | 1 |
| 10 | Improved Phase-Locked Loop for Ro bust and Fast Tracking of Three Phases under Un balanced Electric Grid Conditions显示文摘 | Meral M E | 2012 | lET Genera tion Transmission & Distribution2012，6，2： | 1 |
| 11 | Steroids in acute exacerbations of chronic obstructive pulmonary disease: are nebulized and systemic forms comparable 显示文摘 | Gunen H Mirici A Meral M et aI | 2009 | ? Curr ()pin Pulm Med2009，15，： | 1 |
| 12 | Investigation of norovirus infection incidence among 0-5 years old children with acute gastroenteritis admitted to two different hospitals in ankara, Turkey 显示文摘 | Altay A Bozday G Meral M | 2013 | Article Turkish2013，47，1： | 1 |
| 13 | Inhalation therapy with magnesium sulfate and salbutamol sulfate in bronchial asthma显示文摘 | Meral A Coker M Tanac R | 1996 | Turk J Pe- diatr1996，38，2： | 1 |
| 14 | Comparison of the Efficacy of Nebulised Budesonide with parenteral Corticosteroids in the Treatment of Acute Exacerbations of Chronic Obstructice Pulmonary Disease显示文摘 | MIRICI A MERAL M AKGUN M | 2003 | Clin Drug Invest2003，23，1： | 1 |
| 15 | Natural language watermarking via morphosynatctic alterations显示文摘 | MERAL H M SANKUR B OZSOY A S | 2009 | Computer Speech & Language2009，23，1： | 1 |
| 16 | Two different dosages of nebulized steroid versus parenteral steroid in the management of COPD exacerbations: a randomized control trial 显示文摘 | Yilmazel Ucar E Araz O Meral M | 2014 | Med Sci Monit2014，28，20： | 1 |
| 17 | Effects ofa GnRH agonist on oocyte number and maturation in mice superovulated with eCG and hCG显示文摘 | Kanter M Yildiz C Meral I | 2004 | Theriogenology2004，61，： | 1 |
| 18 | The investigation of occlusal con- tacts during the retention period显示文摘 | Dincer M Meral O Tumer N | 2003 | Angle Orthod2003，73，6： | 1 |
| 19 | Comparison of the Efficacy of Nebulised Budesonide with Parenteral Corticosteroids in the Treatment of Acute Exacerbations of Chronic Obstructive Pulmonary Disease显示文摘 | MIRICI A MERAL M AKGUN M | 2003 | Clin Drug Invest2003，23，1： | 1 |
| 20 | Comparison of the Efficacy of Nebulised Budesonide with Parenteral Corticosteroids in the Treatment of Acute Exacerbations of Chronic Obstructive Pulmonary Disease显示文摘 | MIRICI A MERAL M AKGUN M | 2003 | Clin Drug Invest2003，23，1： | 1 |
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