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| 1 | Inflammatory bowel disease in an underdeveloped region of Northeastern Brazil显示文摘AIM: To evaluate the demographic characteristics and clinical phenotypes of inflammatory bowel disease(IBD) in a geographic area in Northeastern Brazil.METHODS: This retrospective study was conducted at the Hospital of the Federal University of Piauí in Northeastern Brazil. Demographic characteristics and clinical phenotypes of IBD were analyzed in relation to the time of diagnostic confirmation, which was defined as the date of disease onset. Data were collected between January 2011 and December 2012 and included all census patients 18 years of age or older during that period for whom there was diagnostic confirmation of Crohn's disease(CD), ulcerative colitis(UC), or unclassified colitis according to the Montreal criteria. We also analyzed the period of time between the onset of clinical manifestations and the diagnosis of IBD(delay in the diagnosis). Statistical analyses included means and standard deviations for numeric variables and the Pearson χ2 adherence test for nominal variables. The annual index occurrence and overall prevalence of IBD at our institution were also calculated, with P values < 0.05 indicating statistical significance. This study was approved by the Institutional Ethics and Research Committee.RESULTS: A total of 252 patients with IBD were included, including 152(60.3%) UC patients and 100(39.7%) CD patients. The clinical and demographic characteristics of all patients with IBD showed a female to male ratio of 1.3:1.0 and a mean age of35.2(SD = 14.5) years. In addition, the majority of patients were miscegenated(171, 67.9%), had received higher education(157, 62.4%), lived in urban areas(217, 86.1%), and were under the age of 40 years(97, 62.5%). For patients with CD, according to the Montreal classification, the predominant features present from the onset of disease were an age between 17 and 40 years(A2); colonic disease location(L2); and nonstricturing, nonfistulizing disease behavior(B1). However, approximately one-quarter of all CD patients demonstrated perineal involvement. We also observed considerable delay in the diagnosis of IBD throughout the entire study period(mean = 35.5 mo). In addition, the annual index occurrence rose from 0.08 to 1.53 cases/105 inhabitants/year during the study period, and the prevalence rate was 12.8 cases/105 inhabitants in 2012. Over the last two decades, there was a noted increase in the frequency of IBD in the study area.CONCLUSION: In this study, there was a predominance of patients with UC, young people under 40 years of age, individuals with racial miscegenation, and low annual incomes. | José Miguel Luz Parente Claudio Saddy Rodrigues Coy Viriato Campelo Mírian Perpétua Palha Dias Parente Leonardo Araújo Costa Renata Mendes da Silva Celso Stephan José Murilo Robilotta Zeitune | 2015 | World Journal of Gastroenterology2015，21，4： | 3 |
| 2 | Assessing the relationship between the rumen microbiota and feed efficiency in Nellore steers显示文摘Background:Ruminants rely upon a complex community of microbes in their rumen to convert host-indigestible feed into nutrients.However,little is known about the association between the rumen microbiota and feed efficiency traits in Nellore(Bos indicus)cattle,a breed of major economic importance to the global beef market.Here,we compare the composition of the bacterial,archaeal and fungal communities in the rumen of Nellore steers with high and low feed efficiency(FE)phenotypes,as measured by residual feed intake(RFI).Results:The Firmicutes to Bacteroidetes ratio was significantly higher(P<0.05)in positive-RFI steers(p-RFI,low feed efficiency)than in negative-RFI(n-RFI,high feed efficiency)steers.The differences in bacterial composition from steers with high and low FE were mainly associated with members of the families Lachnospiraceae,Ruminococcaceae and Christensenellaceae,as well as the genus Prevotella.Archaeal community richness was lower(P<0.05)in p-RFI than in n-RFI steers and the genus Methanobrevibacter was either increased or exclusive of p-RFI steers.The fungal genus Buwchfawromyces was more abundant in the rumen solid fraction of n-RFI steers(P<0.05)and a highly abundant OTU belonging to the genus Piromyces was also increased in the rumen microbiota of highefficiency steers.However,analysis of rumen fermentation variables and functional predictions indicated similar metabolic outputs for the microbiota of distinct FE groups.Conclusions:Our results demonstrate that differences in the ruminal microbiota of high and low FE Nellore steers comprise specific taxa from the bacterial,archaeal and fungal communities.Biomarker OTUs belonging to the genus Piromyces were identified in animals showing high feed efficiency,whereas among archaea,Methanobrevibacter was associated with steers classified as p-RFI.The identification of specific RFI-associated microorganisms in Nellore steers could guide further studies targeting the isolation and functional characterization of rumen microbes potentially important for the energy-harvesting efficiency of ruminants. | Déborah Romaskevis Gomes Lopes Márcio de Souza Duarte Alex J.La Reau Ibrahim Zuniga Chaves Tiago Antônio de Oliveira Mendes Edenio Detmann Cláudia Braga Pereira Bento Maria Eugênia Zerlotti Mercadante Sarah Figueiredo Martins Bonilha Garret Suen Hilário Cuquetto Mantovani | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 3 |
| 3 | Effectiveness of Helicobacter pylori eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma:An up-to-date meta-analysis显示文摘BACKGROUND Gastric mucosa-associated lymphoid tissue(MALT)lymphoma(GML)is usually a low-grade B-cell neoplasia strongly associated with Helicobacter pylori(H.pylori)-induced chronic gastritis.Clinical practice guidelines currently recommend H.pylori eradication as the preferred initial treatment for early-stage GML.To determine the practical effect of bacterial eradication as the sole initial therapy for early-stage GML,an updated analysis and review of available evidence is imperative.AIM To perform a meta-analysis to assess the rate of complete remission(CR)of H.pylori-positive early-stage GML following bacterial eradication.METHODS We performed independent,computer-assisted literature searches using the PubMed/MEDLINE,Embase,and Cochrane Central databases through September 2022.Prospective and retrospective observational studies evaluating the CR of early-stage GML following bacterial eradication in H.pylori-positive patients.The risk of bias was assessed using Joanna Briggs Institute(JBI)Critical Appraisal Tools.The pooled estimate of the complete histopathological remission rate and respective confidence intervals(95%CI)were calculated following the random-effects model.Heterogeneity and inconsistency were assessed using Cochran’s Q test and I2 statistic,and heterogeneity was defined as P<0.01 and I²>50%,respectively.Subgroup and meta-regression analyses were conducted to explore potential sources of heterogeneity.RESULTS The titles and abstracts of 1576 studies were screened;96 articles were retrieved and selected for full-text reading.Finally,61 studies were included in the proportional meta-analysis(P-MA).Forty-six were prospective and fifteen were retrospective uncontrolled,single-arm,observational studies.The overall risk of bias was low to moderate in all but a single report,with an average critical appraisal score across all studies of 79.02%.A total of 2936 H.pylori-positive early-stage GML patients,in whom H.pylori was successfully eradicated,were included in the analysis.The pooled CR of H.pylori-positive early-stage GML after bacterial eradication was 75.18%(95%CI:70.45%-79.91%).P-MA indicated the substantial heterogeneity in CR reported across studies(I2=92%;P<0.01).Meta-regression analysis identified statistically significant effect modifiers,including the proportion of patients with t(11;18)(q21;q21)-positive GML and the risk of bias in each study.CONCLUSION Comprehensive synthesis of available evidence suggests that H.pylori eradication is effective as the sole initial therapy for early-stage GML.Although the substantial heterogeneity observed across studies limits the interpretation of the pooled overall CR,the present study is a relevant to informing clinical practice. | Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Mariana Santos Calmon Marcel Silva Luz Samuel Luca Rocha Pinheiro Clara Faria Souza Mendes dos Santos Gabriel Lima Correa Santos Hanna Santos Marques Henrique Affonso Delgado Kádima Nayara Teixeira Cláudio Lima Souza Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2023 | World Journal of Gastroenterology2023，29，14： | 2 |
| 4 | Resurfacing of goat articular cartilage by chondrocytes derived from bone marrow 显示文摘 | Butnariu-Ephrat M Robinson D Mendes DG | 1996 | Clin Orthop1996，330，： | 1 |
| 5 | Effect of frozen storage on thechemical and physical properties of black and silver scabbard fish显示文摘 | DAIAS J NUNES M L MENDES R | 1994 | Journal of the Science of Food and Agriculture1994，66，3： | 1 |
| 6 | Cholesterol levels and sensory characteristics of meat from broilers con- suming moderate to high levels of alfalfa显示文摘 | PONTE P I P MENDES I QUARESMA M | 2004 | Poultry Science2004，83，5： | 1 |
| 7 | Short- term electricity prices forecasting in a competitive market by a hybrid intelligent approach显示文摘 | Catal:o J P S Pousinho H M I Mendes V M F | 2011 | Energy Conversion and Management2011，52，： | 1 |
| 8 | Rapid corticosteroid effect on beta(2)-adrenergic airway and airway vascular reactivity in patients with mild asthma显示文摘 | Mendes ES Horvath G Campos M | 2008 | J Allergy Clin Immunol2008，121，3： | 1 |
| 9 | One dimensional model of phase holdups in three phase stratified flow显示文摘 | Khor S H Mendes Tatsis M A Hewitt G F | 1997 | Int J Muhiphase Flow1997，23，5： | 1 |
| 10 | Effect of drying time and the presence of plaque on the in vitro performance of laser florescence in occlusal caries of primary teeth显示文摘 | Mendes FM Hissadomi M Imparato JC | 2004 | Caries Res2004，38，2： | 1 |
| 11 | The Effect of a Psychosocial Intervention and Quality of Life after Acute Myocardial Infarction: The Enhancing Recovery in Coronary Heart Disease (ENRICHD) Clinical Trial显示文摘 | Mendes de Leon C F Czajkowski S M | 2006 | J Cardiopulm Rehabil2006，26，1： | 1 |
| 12 | Coverage of the left subclavian artery during thoracic endovascular aortic repair 显示文摘 | Riesenman P J Farber M A Mendes R R | 2007 | J Vasc Surg2007，45，1： | 1 |
| 13 | Effect of transglutaminaseand carrageenan on restructured fish products containing dietaryfibres 显示文摘 | Cardoso C Mendes R Nunes M L | 2007 | International Journal of Food Science and Technology2007，42，： | 1 |
| 14 | Acclima- tion of Myrtus communis to contrasting Mediterranean light environments effects on structure and chemical composition of foliage and plant water relations 显示文摘 | Mendes M M Gazarini L C Rodrigues M L | 2001 | En- vironmental and Experimental Botany2001，45，2： | 1 |
| 15 | In vivo and in vitro evaluation of an Acetobacter xylinum synthesized microbial cellulose membrane intended forguided tissue repair显示文摘 | Mendes PN Rahal SC Pereira-Junior OC et M | 2009 | Acta Vet Scand2009，51，： | 1 |
| 16 | Cost utility of tumour necrosis factor-α inhibitors for rheumatoid arthritis: an application of Bayesian methods for evidence synthesis in a Markov model 显示文摘 | NGUYEN CM BOUNTHAVONG M MENDES MA | 2012 | Pharmacoeconomics2012，30，7： | 1 |
| 17 | Ectopic micronodular thymoma with lymphoid stroma显示文摘 | Mende S Moschopulos M Marx A | 2004 | Virchows Arch2004，444，4： | 1 |
| 18 | Development of a healthylow-fat fishsausage containing dietary fibre 显示文摘 | Cardoso C Mendes R Nunes M L | 2008 | InternationalJournal of Food Science andTechnology2008，43，： | 1 |
| 19 | Manufacturing Firm Reaction to Supplier Failure and Recovery显示文摘 | Marcos Andre Mendes P Kevin D Rungtusanatham M J | 2007 | International Journal of Operations & Production Management2007，27，3： | 1 |
| 20 | Computing Conditional VaR Using Time-varying Cop- ulas显示文摘 | Mendes B V M | 2005 | Revista Brasileira de Finan~as2005，3，2： | 1 |
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