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| 1 | 红外相机技术在陕西观音山自然保护区兽类监测研究中的应用显示文摘国外使用红外相机技术开展野生动物调查研究已有较长的历史,最早的报道见于Champion(1927),在20世纪90年代逐渐发展成熟,广泛用于动物种群数量和密度的研究。 | 武鹏峰 刘雪华 蔡琼 何祥博 Melissa Songer 朱云 邵小明 | 2012 | 兽类学报2012，32，1： | 138 |
| 2 | 利用红外相机技术分析秦岭有蹄类动物活动节律的季节性差异显示文摘2009年8月至2013年4月期间,在陕西观音山自然保护区,利用18台红外相机收集到羚牛(Budorcas taxicolor)、川西斑羚(Naemorhedus griseus)、中华鬣羚(Capricornis milneedwardsii)、毛冠鹿(Elaphodus cephalophus)、小麂(Muntiacus reevesi)、林麝(Moschus berezovskii)6种有蹄类动物的照片数据,通过相对丰富度指数分析了它们的活动规律及季节性差异。结果表明:(1)6种有蹄类动物在研究区域总丰富度达到了58.71%,其中羚牛的相对丰富度是28.02%,川西斑羚13.24%,毛冠鹿10.08%,中华鬣羚4.21%,小麂2.26%,林麝0.90%。(2)6种有蹄类动物的月相对丰富度反映了其年活动格局,其中羚牛、川西斑羚、毛冠鹿、中华鬣羚、小麂表现出一致性,即夏季活动最为频繁,秋季减弱,冬季达到活动低谷,春季逐渐回升;而林麝则在冬季活动最为频繁,夏季最弱。(3)日时间段相对丰富度反映了动物全年的日活动规律,其中川西斑羚和羚牛相似,主要以白天活动为主;毛冠鹿、小麂、林麝具有明显的晨昏活动习性;中华鬣羚活动高峰出现在02:00–06:00和20:00–22:00,以夜间活动为主。(4)分析不同季节6种有蹄类动物日活动规律,羚牛在春季出现一定的差异,活动高峰出现在16:00–20:00;川西斑羚、毛冠鹿、中华鬣羚在冬季表现出一定的差异,活动高峰相对延迟或者提前;小麂春季表现出差异,活动主要集中在00:00–10:00和18:00–20:00;林麝由于数据相对较少,在4个季节表现出不同的活动规律。(5)夜行性分析得到中华鬣羚具有较强的夜间活动能力,夜间相对丰富度达到了65.81%。这些研究结果有助于监测有蹄类动物种群的变化,为保护区有效保护管理提供了数据支持。 | 贾晓东 刘雪华 杨兴中 武鹏峰 Melissa Songer 蔡琼 何祥博 朱云 | 2014 | 生物多样性2014，22，6： | 72 |
| 3 | Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer显示文摘Long non-coding RNAs(lnc RNAs) play important roles in cancer. They are involved in chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through a variety of chromatin-based mechanisms and via cross-talk with other RNA species. lnc RNAs can function as decoys, scaffolds, and enhancer RNAs. This review summarizes the characteristics of lnc RNAs, including their roles, functions, and working mechanisms, describes methods for identifying and annotating lnc RNAs, and discusses future opportunities for lnc RNA-based therapies using antisense oligonucleotides. | Yiwen Fang Melissa J. Fullwood | 2016 | Genomics, Proteomics & Bioinformatics2016，14，1： | 63 |
| 4 | Bone Morphogenetic Protein (BMP) signaling in development and human diseases显示文摘Bone Morphogenetic Proteins(BMPs)are a group of signaling molecules that belongs to the Transforming Growth Factor-b(TGF-b)superfamily of proteins.Initially discovered for their ability to induce bone formation,BMPs are now known to play crucial roles in all organ systems.BMPs are important in embryogenesis and development,and also in maintenance of adult tissue homeostasis.Mouse knockout models of various components of the BMP signaling pathway result in embryonic lethality or marked defects,highlighting the essential functions of BMPs.In this review,we first outline the basic aspects of BMP signaling and then focus on genetically manipulated mouse knockout models that have helped elucidate the role of BMPs in development.A significant portion of this review is devoted to the prominent human pathologies associated with dysregulated BMP signaling. | Richard N.Wang Jordan Green Zhongliang Wang Youlin Deng Min Qiao Michael Peabody Qian Zhang Jixing Ye Zhengjian Yan Sahitya Denduluri Olumuyiwa Idowu Melissa Li Christine Shen Alan Hu Rex C.Haydon Richard Kang James Mok Michael J.Lee Hue L.Luu Lewis L.Shi | 2014 | Genes & Diseases2014，1，1： | 47 |
| 5 | 应用红外相机技术研究秦岭观音山自然保护区内野猪的行为和丰富度显示文摘2009年7月,在陕西观音山自然保护区凉风垭小区域(中高海拔)和西沟小区域(低海拔)安装18台红外相机,2009年8月至2013年4月共收集野猪照片1 195张。定义9种野猪行为,分别为站立、走动、跑动、采食、饮水、修饰、发情、拱土、坐着休息,并逐一比对照片中野猪的行为,统计各种行为所占的比例;引入月相对丰富度和时间段相对丰富度两个指数分别研究野猪的年活动规律和日活动规律;利用一个种群估测模型探讨野猪密度的年际变化。结果表明:(1)春季野猪以走动、采食和站立为主,分别占总行为次数的36%、25.6%和17.4%;夏季野猪以走动、站立、采食和跑动为主,分别占总行为次数的35.7%、23.6%、17%和16.5%;秋季野猪以采食、走动和发情为主,分别占总行为次数的50.3%、19.3%和17.8%;冬季野猪以采食、走动和站立为主,分别占总行为次数的53.7%、26.7%和11.9%。(2)野猪在8月、9月和12月活动较为频繁;全年日活动高峰出现在午后14:00-16:00,低谷出现在22:00-04:00,四季活动规律不同。(3)2009-2012年野猪密度呈逐年上升趋势。这些研究结果有助于了解野猪的行为活动和种群动态,并采取针对性的措施对野猪进行有效管理。 | 王长平 刘雪华 武鹏峰 蔡琼 邵小明 朱云 Melissa Songer | 2015 | 兽类学报2015，35，2： | 40 |
| 6 | 生存之道:P2P借贷平台的业务模式研究显示文摘现有文献多聚焦于研究P2P网络借贷平台带来的风险及其监管模式,缺乏对于其业务模式的研究。少量针对业务模式的研究成果也仅限于横向比较国内外平台的表象特点,缺乏细致、深入分析。本文不讨论P2P网络借贷平台因操作不规范而引起的各种风险及其监管,而是关注平台如何通过业务模式的改进来降低借贷行为内生的信用风险,从而扩大用户基础,实现规模经营和盈利。理论和西方行业领导者的实践都表明,提高平台对借款人进行信用评级的能力,平台确定贷款利率以及规模经营是平台盈利的关键。 | 宋鹏程 吴志国 Melissa Guzy | 2013 | 新金融2013，，11： | 29 |
| 7 | 水稻抗性淀粉突变体抗性淀粉结构的比较研究显示文摘利用凝胶渗透色谱法和毛细管电泳法对2个富含抗性淀粉的水稻突变体RS111、AE及其野生型亲本R7954、IR36的抗性淀粉组成结构进行了比较研究,分析了2个突变体与野生型亲本抗性淀粉中直链淀粉和支链淀粉的差异。RS111的抗性淀粉主要来源于直链淀粉,支链淀粉所占比例很小,直链淀粉与支链淀粉的比率相对于野生型亲本来说大大提高,从抗性淀粉中支链淀粉的链长分布来看,RS111与R7954比较一致,只是RS111中聚合度为10的短链比例明显小于亲本R7954;而另一突变体AE的抗性淀粉来源中,支链淀粉所占比例很大,直链淀粉与支链淀粉的比率相对于野生型亲本来说变化不大,支链淀粉中聚合度为10左右的短链比例大大高于亲本IR36,而聚合度为16、21左右的中长链比例远远低于亲本。 | 焦桂爱 唐绍清 罗炬 Melissa FITZGERALD Leslie T.ROFEROS 胡培松 | 2006 | 中国水稻科学2006，20，6： | 27 |
| 8 | 江西省高中生校园欺凌影响因素分析显示文摘目的描述江西省南昌市及婺源县高中生校园欺凌发生情况及其影响因素,为减少校园欺凌的发生提供参考。方法采用分层整群随机抽样的方法,在南昌市抽取5所学校,每所学校抽取高一、高二各2个班的学生作为研究对象;婺源县采用整群抽样的方法抽取1所学校,该校所有高一、高二学生作为研究对象,进行校园欺凌情况问卷调查。结果高中生校园欺凌率为26.6%,其中农村地区(OR=1.52)、男性(OR=1.44)、饮酒(OR=1.36)、打架(OR=2.34)、每天上网1~3h(OR=1.29)、每天上网≥3h(OR=1.43)、体型偏瘦(OR=1.25)是校园欺凌发生的危险因素(P值均<0.05);而父母有时关心(OR=0.58)、父母经常关心(OR=0.70)是校园欺凌发生的保护因素(P值均<0.05)。就非人口学危险因素而言,与无危险因素者相比,危险因素增加至≥3个时发生校园欺凌的可能性增加1.93倍(P<0.01)。结论江西省高中生校园欺凌的发生是多种因素共同作用产生的结果。教育部门及家庭应共同努力为青少年创建积极健康的学习生活环境。减少校园欺凌的发生。 | 王健 李春玫 谢飞 姜小庆 Melissa Deadmond Gabriela Vieyra 戴新平 杨维 袁兆康 | 2018 | 中国学校卫生2018，39，12： | 23 |
| 9 | Synchronous colorectal cancer: Clinical, pathological and molecular implications显示文摘Synchronous colorectal carcinoma refers to more than one primary colorectal carcinoma detected in a single patient at initial presentation.A literature review has shown that the prevalence of the disease is approximately 3.5%of all colorectal carcinomas.This disease has a male to female ratio of 1.8:1.The mean age at presentation of patients with synchronous colorectal cancer is in the early half of the seventh decade.Patients with inflammatory bowel diseases(ulcerative colitis and Crohn’s disease),hereditary non-polyposis colorectal cancer,familial adenomatous polyposis and serrated polyps/hyperplastic polyposis are known to have a higher risk of synchronous colorectal carcinoma.These predisposing factors account for slightly more than 10%of synchronous colorectal carcinomas.Synchronous colorectal carcinoma is more common in the right colon when compared to solitary colorectal cancer.On pathological examination,some synchronous colorectal carcinomas are mucinous adenocarcinomas.They are usually associated with adenomas and metachronous colorectal carcinomas.Most of the patients with synchronous colorectal cancer have two carcinomas but up to six have been reported in one patient.Patients with synchronous colorectal carcinoma havea higher proportion of microsatellite instability cancer than patients with a solitary colorectal carcinoma.Also,limited data have revealed that in many synchronous colorectal carcinomas,carcinomas in the same patient have different patterns of microsatellite instability status,p53 mutation and K-ras mutation.Overall,the prognosis of patients with synchronous colorectal carcinoma is not significantly different from that in patients with solitary colorectal carcinoma,although a marginally better prognosis has been reported in patients with synchronous colorectal carcinoma in some series.A different management approach and long-term clinical follow-up are recommended for some patients with synchronous colorectal cancer. | Alfred King-Yin Lam Sally Sze-Yan Chan Melissa Leung | 2014 | World Journal of Gastroenterology2014，20，22： | 22 |
| 10 | 一种高效便捷的水稻DNA提取法及其应用显示文摘以水稻叶片、根和种子为材料,采用高通量快速法提取基因组DNA,用稻瘟病Pita基因分子标记进行检测,获得与预期片段大小一致的特异性条带,对165份育种材料的检测结果与稻瘟病接种鉴定一致。操作方法如下:将少量水稻叶片、根或种子放入200μL PCR盘中,加入70μL缓冲液A(含NaOH和Tween20),在PCR仪中加热到95℃,保持10min,再加入70μL缓冲液B(Tris-HCl和EDTA),该提取液可以直接用于PCR扩增。该方法具有几个优点:1)成本低,仅用4种化学试剂,共140μL提取液;2)操作简便,仅需3步,每人每天可以提取上千份样品;3)仪器设备简单,只用常规的PCR仪;4)可直接提取干种子的DNA;5)DNA质量好,能检测出水稻中的抗稻瘟病单基因Pita,并且与稻瘟病接种鉴定结果一致;6)用量少,只需要5~20mg叶片、20mg根或半粒籽粒。尤其是检测大量样本的基因型时,此种方法更显得高效便捷。 | 赵国珍 贾育林 严宗卜 Christopher W DEREN Melissa H JIA 戴陆园 | 2012 | 中国水稻科学2012，26，4： | 21 |
| 11 | 我国P2P借贷行业监管模式研究显示文摘近年来P2P借贷行业在我国迅速发展,但目前我国还没有建立起相应的监管架构。本文对P2P借贷的优势和风险进行了分析,在借鉴英美等国P2P借贷行业监管经验的基础上,认为我国的P2P借贷监管应当兼顾投融资效率和投资者保护,在维护投资者利益的同时尽量给P2P借贷平台足够的发展空间;加快民间信贷和隐私保护等立法进程刻不容缓;P2P借贷行业应当由中央银行和银监会联合监管,并需要建立行业协会,促进行业自律。 | 宋鹏程 吴志国 赵京 Melissa Guzy | 2014 | 南方金融2014，，1： | 21 |
| 12 | 海拔对大熊猫主食竹结构、营养及大熊猫季节性分布的影响显示文摘大熊猫主要采食竹子,主食竹对大熊猫生存具有重要的作用。秦岭佛坪地区的大熊猫主要取食巴山木竹和秦岭箭竹。本文研究了海拔对这两种竹林的结构与营养含量的影响以及海拔与大熊猫季节性分布的关系。结果表明:(1)海拔对竹林基径、株高有显著影响(P<0.05);整齐度、均匀度、基径和株高分布的偏度值和峰度值均随海拔变化而变化。(2)海拔对主食竹营养含量的影响随季节而变化(春季:粗蛋白和总糖P=0.02;夏季:粗纤维P=0.01;秋季:粗蛋白P=0.04、粗纤维P=0.04和总糖P<0.01)。每个竹种在叶、枝、杆3个部位间的营养均有显著性差异(P<0.05)。(3)海拔对竹林结构及营养的显著影响决定了大熊猫对主食竹的取食策略,夏季在高海拔活动,其余季节在低海拔活动。本文研究结果对理解海拔、主食竹结构、营养以及大熊猫迁移活动之间的关系有重要作用,为圈养大熊猫的饲料配比提供理论依据,也为野外大熊猫的保护和规范保护区内部的人类活动提供科学支撑。 | 李亚军 蔡琼 刘雪华 Melissa Songer 武鹏峰 贾晓东 何祥博 | 2016 | 兽类学报2016，36，1： | 17 |
| 13 | From targeting the tumor to targeting the immune system: Transversal challenges in oncology with the inhibition of the PD-1/PD-L1 axis显示文摘After that the era of chemotherapy in the treatment of solid tumors have been overcome by the 'translational era', with the innovation introduced by targeted therapies, medical oncology is currently looking at the dawn of a new 'immunotherapy era' with the advent of immune checkpoint inhibitors(CKI) antibodies.The onset of PD-1/PD-L1 targeted therapy has demonstrated the importance of this axis in the immune escape across almost all human cancers.The new CKI allowed to significantly prolong survival and to generate durable response, demonstrating remarkable efficacy in a wide range of cancer types.The aim of this article is to review the most up to date literature about the clinical effectiveness of CKI antibodies targeting PD-1/PD-L1 axis for the treatment of advanced solid tumors and to explore transversal challenges in the immune checkpoint blockade. | Melissa Bersanelli Sebastiano Buti | 2017 | World Journal of Clinical Oncology2017，8，1： | 15 |
| 14 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 15 | Toxic stress,inflammation and symptomatology of chronic complications in diabetes显示文摘Diabetes affects at least 382 million people worldwide and the incidence is expected to reach 592 million by 2035.The incidence of diabetes in youth is skyrocketing as evidenced by a 21% increase in type 1 diabetes and a 30.5% increase in type 2 diabetes in the United States between 2001 and 2009.The effects of toxic stress,the culmination of biological and environmental interactions,on the development of diabetes complications is gaining attention.Stress impacts the hypothalamus-pituitaryadrenal axis and contributes to inflammation,a keybiological contributor to the pathogenesis of diabetes and its associated complications.This review provides an overview of common diabetic complications such as neuropathy,cognitive decline,depression,nephropathy and cardiovascular disease.The review also provides a discussion of the role of inflammation and stress in the development and progression of chronic complications of diabetes,associated symptomatology and importance of early identification of symptoms of depression,fatigue,exercise intolerance and pain. | Charles A Downs Melissa Spezia Faulkner | 2015 | World Journal of Diabetes2015，6，4： | 12 |
| 16 | 复杂并发症产生在简单并且 polycystic 肝包囊显示文摘 Liver cysts are common,affecting 5%-10% of the population.Most are asymptomatic,however 5% of patients develop symptoms,sometimes due to complications and will require intervention.There is no consensus on their management because complications are so uncommon.The aim of this study was to perform a collected review of how a series of complications were managed at our institutions.Six different patients presenting with rare complications of liver cysts were obtained from Hepatobiliary Units in the United Kingdom and The Netherlands.History and radiological imaging were obtained from case notes and computerised radiology.As a result,1 patient admitted with inferior vena cava obstruction was managed by cyst aspiration and lanreotide;1 patient with common bile duct obstruction was first managed by endoscopic retrograde cholangiopancreatography and stenting,followed by open fenestration;1 patient with ruptured cysts and significant medical co-morbidities was managed by percutaneous drainage;1 patient with portal vein occlusion and varices was managed by open liver resection;1 patient with infected cysts was treated with intravenous antibiotics and is awaiting liver transplantation.The final patient with a simple liver cyst mimicking a hydatid was managed by open liver resection.In conclusion,complications of cystic liver disease are rare,and we have demonstrated in this series that both operative and non-operative strategies have defined roles in management.The mainstays of treatment are either aspiration/sclerotherapy or,alternatively laparoscopic fenestration.Medical management with somatostatin analogues is a potentially new and exciting treatment option but requires further study. | Christian Macutkiewicz Ricci Plastow Melissa Chrispijn Rafik Filobbos Basil A Ammori David J Sherlock Joost PH Drenth Derek A O’Reilly | 2012 | World Journal of Hepatology2012，4，12： | 10 |
| 17 | Management of gastroesophageal reflux disease: Patient and physician communication challenges and shared decision making显示文摘Gastroesophageal reflux disease(GERD) is a common upper esophageal condition and typical symptoms can include heartburn and sensation of regurgitation while atypical symptoms include chronic cough, asthma, hoarseness, dyspepsia and nausea. Typically, diag-nosis is presumptive given the presence of typical and atypical symptoms and is an indication for empiric therapy. Treatment management can include lifestyle modifications and/or medication therapy with proton pump inhibitor(PPI) class being the preferred and most effective. Complete symptom resolution is not always achieved and long-term PPI therapy can put patients at risk for serious side effects and needless expense. The brain-gut connection and hypervigilance plays an important role in symptom resolution and treatment success, especially in the case of non-PPI responders. Hypervigilance is a combination of increased esophageal sensory sensitivity in combination with exaggerated threat perception surrounding esophageal symptoms. Hypervigilance requires a different approach to GERD managements, where continued PPI therapy and surgery are usually not recommended. Rather, helping physicians and patients understand the brain-gut connection can guide and improve care.Education and reassurance should be the main pillars or treatment. However, it is important not to suggest the symptoms are due to anxiety alone, this often leads to patient dissatisfaction. Patient dissatisfaction with treatment reveals the need for a more patient-centered approach to GERD management and better communication between patients and providers. Shared decision making(SDM) with the incorporation of patient-reported outcomes(PRO) promotes patient adherence and satisfaction. SDM is a joint discussion between clinician and patient in which a mutually shared solution is explored for GERD symptoms. For SDM to work the physician needs to capture patients' perceptions which may not be obtained in the standard interview. This can be done through the use of PROs which promote a dialogue with patients about their symptoms and treatment priorities in the context of the SDM patient encounter. SDM could potentially help in the management of patient expectations for GERD treatment, ultimately positively impacting their health-related quality of life. | Scott Klenzak Igor Danelisen Grace D Brannan Melissa A Holland Miranda AL van Tilburg | 2018 | World Journal of Clinical Cases2018，6，15： | 10 |
| 18 | Upper gastrointestinal tract capsule endoscopy using a nurse-led protocol: First reported experience显示文摘AIM To test the feasibility and performance of a novel upper gastrointestinal(GI) capsule endoscope using a nurse-led protocol. METHODS We conducted a prospective cohort analysis of patients who declined gastroscopy(oesophagogastroduodenoscopy, OGD) but who consented to upper GI capsule endoscopy. Patients swallowed the upper GI capsule following ingestion of 1 liter of water(containing simethicone). A series of positional changes were used to exploit the effects of water flow and move the upper GI capsule from one gravity-dependent area to another using a nurse-led protocol. Capsule transit time, video reading time, mucosal visualisation, pathology detection and patient tolerance was evaluated.RESULTS Fifty patients were included in the study. The mean capsule transit times in the oesophagus and stomach were 28 s and 68 min respectively. Visualisation of the following major anatomical landmarks was achieved(graded 1-5: Poor to excellent): Oesophagus, 4.8(± 0.5); gastro-oesophageal junction(GOJ), 4.8(± 0.8); cardia, 4.8(± 0.8); fundus, 3.8(± 1.2); body, 4.5(± 1); antrum, 4.5(± 1); pylorus, 4.7(± 0.8); duodenal bulb, 4.7(± 0.7); second part of the duodenum(D2), 4.7(± 1). The upper GI capsule reached D2 in 64% of patients. The mean video reading time was 48 min with standard playback mode and 20 min using Quickview(P = 0.0001). No pathology was missed using Quickview. Procedural tolerance was excellent. No complications were seen with the upper GI capsule. CONCLUSION The upper GI capsule achieved excellent views of the upper GI tract. Future studies should compare the diagnostic accuracy between upper GI capsule and OGD. | Hey-Long Ching Ailish Healy Victoria Thurston Melissa F Hale Reena Sidhu Mark E McAlindon | 2018 | World Journal of Gastroenterology2018，24，26： | 9 |
| 19 | Capsule endoscopy:Current practice and future directions显示文摘Capsule endoscopy(CE)has transformed investigation of the small bowel providing a non-invasive,well tolerated means of accurately visualising the distal duodenum,jejunum and ileum.Since the introduction of small bowel CE thirteen years ago a high volume of literature on indications,diagnostic yields and safety profile has been presented.Inclusion in national and international guidelines has placed small bowel capsule endoscopy at the forefront of investigation into suspected diseases of the small bowel.Most commonly,small bowel CE is used in patients with suspected bleeding or to identify evidence of active Crohn’s disease(CD)(in patients with or without a prior history of CD).Typically,CE is undertaken after upper and lower gastrointestinal flexible endoscopy has failed to identify a diagnosis.Small bowel radiology or a patency capsule test should be considered prior to CE in those at high risk of strictures(such as patients known to have CD or presenting with obstructive symptoms)to reduce the risk of capsule retention.CE also has a role in patients with coeliac disease,suspected small bowel tumours and other small bowel disorders.Since the advent of small bowel CE,dedicated oesophageal and colon capsule endoscopes have expanded the fields of application to include the investigation of upper and lower gastrointestinal disorders.Oesophageal CE may be used to diagnose oesophagitis,Barrett’s oesophagus and varices but reliability in identifying gastroduodenal pathology is unknown and it does not have biopsy capability.Colon CE provides an alternative to conventional colonoscopy for symptomatic patients,while a possible role in colorectal cancer screening is a fascinating prospect.Current research is already addressing the possibility of controlling capsule movement and developing capsules which allow tissue sampling and the administration of therapy. | Melissa F Hale Reena Sidhu Mark E McAlindon | 2014 | World Journal of Gastroenterology2014，20，24： | 9 |
| 20 | Alumina-coated Ag nanocrystal monolayers as surfaceenhanced Raman spectroscopy platforms for the direct spectroscopic detection of water splitting reaction intermediates显示文摘 | Xing Yi Ling Ruoxue Yan Sylvia Lo Dat Tien Hoang Chong Liu Melissa A. Fardy Sher Bahadar Khan Abdullah M. Asiri Salem M. Bawaked Peidong Yang | 2014 | Nano Research2014，7，1： | 8 |
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