|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 捻针时真、假穴不同中枢激活效应的脑功能MRI显示文摘目的 利用功能磁共振 (fMRI)观察捻针针刺方法对大脑的作用。方法 用盲法随机分别针刺 13例正常人左侧太冲、丘墟和假穴 ,手法采用捻针和不捻针 ,利用 1 5TMR仪行全脑功能成像 ,用SPM99b分析图像。结果 发现只在真穴捻针针刺时有更强的激活效应 ,有显著性意义的Brodmann激活区域为 :针刺太冲穴激活了左右顶叶BA4 0区 ,右额叶BA4 7和 10区 ,右丘脑 ,左小脑 ;针刺丘墟穴激活了左右顶叶BA4 0区 ,右顶叶BA2区 ,左额叶BA9、10、4 4区 ,左岛叶BA13区 ,左颞叶BA2 2区 ,右颞叶BA4 2区 ,右壳核 ,左小脑。两真穴激活部位部分相同 ,部分不同。在假穴捻针对不捻针的研究中 ,未见到有显著性意义的激活区。结论 真穴捻针时可能对皮层神经活动有较特异的作用 ,而假穴未观察到此种现象 ,推测这可能是针刺治疗作用的机制之一。 | 方继良 Timo Krings Juergen Weidemann Ingo Meister Armin Thron | 2004 | 中华放射学杂志2004，38，12： | 40 |
| 2 | Intraductal ultrasound substantiates diagnostics of bile duct strictures of uncertain etiology显示文摘AIM:To report the largest patient cohort study investigating the diagnostic yield of intraductal ultrasound (IDUS) in indeterminate strictures of the common bile duct.METHODS:A patient cohort with bile duct strictures of unknown etiology was examined by IDUS.Sensitivity,specificity and accuracy rates of IDUS were calculated relating to the definite diagnoses proved by histopathology or long-term follow-up in those patients who did not undergo surgery.Analysis of the endosonographic report allowed drawing conclusions with respect to the T and N staging in 147 patients.IDUS staging was compared to the postoperative histopathological staging data allowing calculation of sensitivity,specificity and accuracy rates for T and N stages.The endoscopic retrograde cholangio-pancreatography and IDUS procedures were performed under fluoroscopic guidance using a side-viewing duodenoscope (Olympus TJF 160,Olympus,Ltd.,Tokyo,Japan).All procedures were performed under conscious sedation (propofol combined with pethidine) according to the German guidelines.For IDUS,a 6 F or 8 F ultrasound miniprobe was employed with a radial scanner of 15-20 MHz at the tip of the probe (Aloka Co.,Tokyo,Japan).RESULTS:A total of 397 patients (210 males,187 females,mean age 61.43 ± 13 years) with indeterminate bile duct strictures were included.Two hundred and sixty-four patients were referred to the department of surgery for operative exploration,thus surgical histopathological correlation was available for those patients.Out of 264 patients,174 had malignant disease proven by surgery,in 90 patients benign disease was found.In these patients decision for surgical exploration was made due to suspicion for malignant disease in multimodal diagnostics (computed tomography scan,endoscopic ultrasound or magnetic resonance imaging).Twenty benign bile duct strictures were misclassified by IDUS as malignant while 14 patients with malignant strictures were initially misdiagnosed by IDUS as benign resulting in sensitivity,specificity and accuracy ratesof 93.2%,89.5% and 91.4%,respectively.In the subgroup analysis of malignancy prediction,IDUS showed best performance in cholangiocellular carcinoma as underlying disease (sensitivity rate,97.6%) followed by pancreatic carcinoma (93.8%),gallbladder cancer (88.9%) and ampullary cancer (80.8%).A total of 133 patients were not surgically explored.32 patients had palliative therapy due to extended tumor disease in IDUS and other imaging modalities.Ninety-five patients had benign diagnosis by IDUS,forceps biopsy and radiographic imaging and were followed by a surveillance protocol with a follow-up of at least 12 mo;the mean follow-up was 39.7 mo.Tumor localization within the common bile duct did not have a significant influence on prediction of malignancy by IDUS.The accuracy rate for discriminating early T stage tumors (T1) was 84% while for T2 and T3 malignancies the accuracy rates were 73% and 71%,respectively.Relating to N0 and N1 staging,IDUS procedure achieved accuracy rates of 69% for N0 and N1,respectively.Limitations:Pretest likelihood of 52% may not rule out bias and overinterpretation due to the clinical scenario or other prior performed imaging tests.CONCLUSION:IDUS shows good results for accurate diagnostics of bile duct strictures of uncertain etiology thus allowing for adequate further clinical management. | Tobias Meister Hauke S Heinzow Carina Woestmeyer Philipp Lenz Josef Menzel Torsten Kucharzik Wolfram Domschke Dirk Domagk | 2013 | World Journal of Gastroenterology2013，19，6： | 19 |
| 3 | Clinical outcome and predictors of survival after TIPS insertion in patients with liver cirrhosis显示文摘AIM:To determine the clinical outcome and predictors of survival after transjugular intrahepatic portosystemic stent shunt (TIPS) implantation in cirrhotic patients. METHODS:Eighty-one patients with liver cirrhosis and consequential portal hypertension had TIPS implantation (bare metal) for either refractory ascites (RA) (n= 27) or variceal bleeding (VB) (n = 54). Endpoints for the study were:technical success, stent occlusion and stent stenosis, rebleeding, RA and mortality. Clinical records of patients were collected and analysed. Baseline characteristics [e.g., age, sex, CHILD score and the model for end-stage liver disease score (MELD score), underlying disease] were retrieved. The Kaplan-Meier method was employed to calculate survival from the time of TIPS implantation and comparisons were made by log rank test. A multivariate analysis of factors influencing survival was carried out using the Cox proportional hazards regression model. Results were expressed as medians and ranges. Comparisons between groups were performed by using the Mann-Whitney Utest and the χ 2 test as appropriate. RESULTS:No difference could be seen in terms of age, sex, underlying disease or degree of portal pressure gradient (PPG) reduction between the ascites and the bleeding group. The PPG significantly decreased from 23.4 ± 5.3 mmHg (VB) vs 22.1 ± 5.5 mmHg (RA) before TIPS to 11.8 ± 4.0 vs 11.7 ± 4.2 after TIPS implantation (P = 0.001 within each group). There was a tendency towards more patients with stage CHILD A in the bleeding group compared to the ascites group (24 vs 6, P = 0.052). The median survival for the ascites group was 29 mo compared to > 60 mo for the bleeding group (P = 0.009). The number of radiological controls for stent patency was 6.3 for bleeders and 3.8 for ascites patients (P = 0.029). Kaplan-Meier calculation indicated that stent occlusion at first control (P = 0.027), ascites prior to TIPS implantation (P = 0.009), CHILD stage (P = 0.013), MELD score (P = 0.001) and those patients not having undergone liver transplantation (P = 0.024) were significant predictors of survival. In the Cox regression model, stent occlusion (P = 0.022), RA (P = 0.043), CHILD stage (P = 0.015) and MELD score (P = 0.004) turned out to be independent prognostic factors of survival. The anticoagulation management (P = 0.097), the porto-systemic pressure gradient (P= 0.460) and rebleeding episodes (P = 0.765) had no significant effect on the overall survival. CONCLUSION:RA, stent occlusion, initial CHILD stage and MELD score are independent predictors of survival in patients with TIPS, speaking for a close follow-up in these circumstances. | Hauke S Heinzow Philipp Lenz Michael Khler Frank Reinecke Hansjrg Ullerich Wolfram Domschke Dirk Domagk Tobias Meister | 2012 | World Journal of Gastroenterology2012，18，37： | 17 |
| 4 | Comparative analysis of ERCP,IDUS,EUS and CT in predicting malignant bile duct strictures显示文摘AIM:To compare endoscopic retrograde cholangio-pancreatography(ERCP),intraductal ultrasound(IDUS),endosonography(EUS),endoscopic transpapillary forceps biopsies(ETP)and computed tomography(CT)with respect to diagnosing malignant bile duct strictures.METHODS:A patient cohort with bile duct strictures of unknown etiology was examined by ERCP and IDUS,ETP,EUS,and CT.The sensitivity,specificity,and accuracy rates of the diagnostic procedures were calculated based on the definite diagnoses proved by histopathology or long-term follow-up in those patients who did not undergo surgery.For each of the diagnostic measures,the sensitivity,specificity,and accuracy rates were calculated.In all cases,the gold standard was the histopathologic staging of specimens or long-term follow-up of at least 12 mo.A comparison of the accuracy rates between the localization of strictures was performed by using the Mann-Whitney U-test and theχ2test as appropriate.A comparison of the accuracy rates between the diagnostic procedures was performed by using the McNemar’s test.Differences were considered statistically significant if P<0.05.RESULTS:A total of 234 patients(127 males,107 females,median age 64,range 20-90 years)with indeterminate bile duct strictures were included.A total of 161patients underwent operative exploration;thus,a surgical histopathological correlation was available for those patients.A total of 113 patients had malignant disease proven by surgery;in 48 patients,benign disease was surgically found.In these patients,the decision for surgical exploration was made due to the suspicion of malignant disease in multimodal diagnostics(ERCP,CT,or EUS).Fifty patients had a benign diagnosis and were followed by a surveillance protocol with a followup of at least 12 mo;the median follow-up was 34 mo.Twenty-three patients had extended malignant disease,and thus were considered palliative.A comparison of the different diagnostic tools for detecting bile duct malignancy resulted in accuracy rates of 91%(ERCP/IDUS),59%(ETP),92%(IDUS+ETP),74%(EUS),and 73%(CT),respectively.In the subgroup analysis,the accuracy rates(%,ERCP+IDUS/ETP/IDUS+ETP;EUS;CT)for each tumor entity were as follows:cholangiocellular carcinoma:92%/74%/92%/70%/79%;pancreatic carcinoma:90%/68%/90%/81%/76%;and ampullary carcinoma:88%/90%/90%/76%/76%.The detection rate of malignancy by ERCP/IDUS was superior to ETP(91%vs 59%,P<0.0001),EUS(91%vs74%,P<0.0001)and CT(91%vs 73%,P<0.0001);EUS was comparable to CT(74%vs 73%,P=0.649).When analyzing accuracy rates with regard to localization of the bile duct stenosis,the accuracy rate of EUS for proximal vs distal stenosis was significantly higher for distal stenosis(79%vs 57%,P<0.0001).CONCLUSION:ERCP/IDUS is superior to EUS and CT in providing accurate diagnoses of bile duct strictures of uncertain etiology.Multimodal diagnostics is recommended. | Hauke S Heinzow Sara Kammerer Carina Rammes Johannes Wessling Dirk Domagk Tobias Meister | 2014 | World Journal of Gastroenterology2014，20，30： | 14 |
| 5 | 基因污染对粮食作物的威胁显示文摘本文举例说明了基因污染对粮食作物的威胁以及生物多样性的危害,并呼吁国际社会对转基因作物及产品进行管理。 | Isabelle Meister | 2002 | 世界环境2002，，4： | 9 |
| 6 | Emerging blood-based biomarkers for detection of gastric cancer显示文摘Early detection and efficient monitoring of tumor dynamics are prerequisites for reducing disease burden and mortality, and for improving the management of patients with gastric cancer(GC). Blood-based biomarker assays for the detection of early-stage GC could be of great relevance both for population-wide or risk groupbased screening programs, while circulating biomarkers that reflect the genetic make-up and dynamics of the tumor would allow monitoring of treatment efficacy, predict recurrences and assess the genetic heterogeneity of the tumor. Recent research to identify blood-based biomarkers of GC has resulted in the identification of a wide variety of cancer-associated molecules, including various proteins, autoantibodies against tumor associated antigens, cell-free DNA fragments, m RNAs and various non-coding RNAs, circulating tumor cells and cancer-derived extracellular vesicles. Each type of these biomarkers provides different information on the disease status, has different advantages and disadvantages, and distinct clinical usefulness. In the current review, we summarize the recent developments in blood-based GC biomarker discovery, discuss the origin of various types of biomarkers and their clinical usefulness and the technological challenges in the development of biomarker assays for clinical use. | Zane Kalnina Irēna Meistere Ilze Kikuste Ivars Tolmanis Pawel Zayakin Aija Linē | 2015 | World Journal of Gastroenterology2015，21，41： | 7 |
| 7 | The effect of microclimate on wood decay is indirectly altered by tree species diversity in a litterbag study显示文摘Aims We studied the influence of tree species diversity on the dynamics of coarse wood decomposition in developing forest communities in a natural,topographically heterogeneous landscape.Using the litter bag technique,we investigated how and to which extent canopy tree species richness or the exclusion of mesoinvertebrates and macroinvertebrates affected wood decomposition in the light of natural variations in the microclimate.We compared the relative importance of the two aspects(experimental treatment versus microclimate)on wood decay rates using Schima superba as a standard litter.Methods Coarse woody debris(CWD)was deposited in litter bags with two different mesh sizes in a total of 134 plots along a gradient of canopy tree species richness(0-24 species).Wood decomposition was assessed at two consecutive time points,one and three years after deposition in the field.Local climatic conditions were assessed throughout the duration of the experiment.Microclimatic conditions were assessed both,directly in the field as well as indirectly via correlations with local topography.We used analysis of variance based approaches to assess the relative importance of the treatments(community tree species richness and macro invertebrate exclusion)and microclimatic conditions on wood decay.Important Findings No direct influence of tree species richness on wood decay could be detected.However,the exclusion of macroinvertebrates significantly decreased wood decomposition rates.In addition,microclimatic conditions accounted for a substantial proportion of explained variance in the observed data.Here,wood decomposition was negatively affected by low mean temperatures and high variations in local humidity and temperature.However,tree species richness as well as the respective species composition affected the presence of termites within forest communities.These,in turn,significantly increased the decay of CWD.The strength of both,experimental treatment and microclimate increased with ongoing decomposition.We conclude that,while tree species richness per se has no direct influence on wood decomposition,its influence on the local arthropod decomposer community(especially the presence of termites)does have an effect. | David Eichenberg Katherina Pietsch Christian Meister Wenyong Ding Mingjian Yu Christian Wirth | 2017 | Journal of Plant Ecology2017，10，1： | 5 |
| 8 | Effect of fish oil enriched enteral diet on inflammatory bowel disease tissues in organ culture: Differential effects on ulcerative colitis and Crohn's disease显示文摘AIM: To investigate the influence of fish oil enriched enteral diet on intestinal tissues taken from Crohn's disease (CD), ulcerative colitis (UC) and non-inflamed non-IBD control patients in vitro.METHODS: Colonoscopic biopsies from patients with active CD (n = 4), active UC (n = 7), and non-inflamed non-IBD control patients (n = 4) were incubated (three dilutions of 1:20, 1:10, and 1:5) with Waymouth's culture medium and enteral elemental diet (EO28, SHS, Liverpool, UK) modified in the fatty acid composition with fish oil (EF) in an organ culture system for 24 h. In each experimental set-up, incubation with Waymouth's medium alone as control was included. Tissue viability was assessed by adding bromodeoxyuridine (BrdU) to the culture fluid and immunohistochemically staining for BrdU uptake. Cytokine ratio of IL-1ra/IL-1β (low ratio indicative of inflammation) and production of those cytokines as a percentage of medium control were assayed in the culture supernatant. RESULTS: Incubation of CD-affected tissue with EF (1:20, 1:10, and 1:5) modestly and non-significantly increased IL-1ra/IL-1β ratio as compared with medium control (CD 39.1±16.1; 26.5±7.8, 47.1±16.8 vs control 13.0±2.2), but incubation of UC-affected tissues increased IL-1ra/IL-1β ratio significantly in all three dilutions (UC 69.1±32.2, P<0.05; 76.1±36.4, P = 0.05;84.5±37.3, P<0.02; vs control 10.2±3.7). Incubation of non-inflamed non-IBD control tissue did not increase the IL-1ra/IL-1β ratio in any dilution compared to medium control (69.3±47.0, 54.1±30.6, 79.4±34.0 vs control 76.1±37.3). Average percentage production of IL-1β indexed against medium control was significantly less in UC after EF incubation as compared with CD (UC 24.0±4.8 vs CD 51.8±8.1; P<0.05). Average percentage production of IL-1ra was markedly higher in UC (135.9±3.4) than that in control patients (36.5±4.3) (P<0.0001).CONCLUSION: IBD tissues, after incubation with elemental diet modified in its fatty acid composition with fish oil, show an increase in IL-1ra/IL-1β cytokine ratio. This effect of ω-3 fatty acid modulation is significantly more marked in UC compared with CD and is accompanied by both a reduction of IL-1β and increase of IL-1ra. The positive direct anti-inflammatory effect of elemental diet with fish oil in tissue affected with UC suggests dietary treatment of UC may be possible. | Doris Meister Subrata Ghosh | 2005 | World Journal of Gastroenterology2005，11，47： | 5 |
| 9 | Colon capsule endoscopy versus standard colonoscopy in assessing disease activity of ulcerative colitis: a prospective trial显示文摘 | T. Meister H. S. Heinzow D. Domagk A. Dortgolz F. Lenze M. Ross W. Domschke A. Lügering | 2013 | Techniques in Coloproctology2013，，6： | 4 |
| 10 | SJGT14082900000151显示文摘 | Jean-Marc Dumonceau Angelo Andriulli B. Elmunzer Alberto Mariani Tobias Meister Jacques Deviere Tomasz Marek Todd Baron Cesare Hassan Pier Testoni Christine Kapral | 2014 | Endoscopy2014，，： | 3 |
| 11 | Modeling stochastic noise in gene regulatory systems显示文摘 | Arwen Meister Chao Du Ye Henry Li Wing Hung Wong | 2014 | Frontiers of Electrical and Electronic Engineering in China2014，9，1： | 2 |
| 12 | The anti-apoptotic livin gene is an important determinant for the apoptotic resistance of non-small cell lung cancer cells 显示文摘 | Crnkovic - Mertens I Muley T Meister M | 2006 | Lung Cancer2006，54，2： | 1 |
| 13 | Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition显示文摘 | MEISTER S SCHUBERT U NEUBERT K | 2007 | Center Res2007，67，： | 1 |
| 14 | Determining the importance of fundamental hearing aid attributes显示文摘 | MEISTER H LAUSBERG I KIESSLING J | 2002 | Otology & Neurotology2002，23，4： | 1 |
| 15 | Upregulation of ' operativeα2/β2 adrenoceptor ratio' by high salt diet predicts blood press ure response in salt sensitive subjects显示文摘 | Kotanko P Meister B | 1987 | J Cardrovase Pharmacol1987，10，4： | 1 |
| 16 | Genome expression analysis of Anopheles gambiae:responses to injury,bacterial challenge,and malaria infection 显示文摘 | Dimopoulos G Christophides G K Meister S | 2002 | Proceeding of National Academy of Science of United states of America2002，99，： | 1 |
| 17 | Mechanisms of gene silencing by double-stranded RNA 显示文摘 | Meister G Tuschl T | 2004 | Nature2004，431，7006： | 1 |
| 18 | Mechanisms of gene silencing by double stranded RNA显示文摘 | Meister G Tuschl T | 2004 | Nature2004，431，7006： | 1 |
| 19 | Vanadium peroxide complexes显示文摘 | Butler A Clague M J Meister G E | 1994 | Chem Rev1994，94，3： | 1 |
| 20 | Wanted :A bad matrix 显示文摘 | Meisters G H | 1995 | The American Mathematical Monthly1995，102，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员