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| 1 | Visceral hypersensitivity in inflammatory bowel diseases and irritable bowel syndrome: The role of proteases显示文摘Proteases, enzymes catalyzing the hydrolysis of peptide bonds, are present at high concentrations in the gastrointestinal tract. Besides their well-known role in the digestive process, they also function as signaling molecules through the activation of protease-activated receptors(PARs). Based on their chemical mechanism for catalysis, proteases can be classified into several classes: serine, cysteine, aspartic, metallo- and threonine proteases represent the mammalian protease families. In particular, the class of serine proteases will play a significant role in this review. In the last decades, proteases have been suggested to play a key role in the pathogenesis of visceral hypersensitivity, which is a major factor contributing to abdominal pain in patients with inflammatory bowel diseases and/or irritable bowel syndrome. So far, only a few preclinical animal studies have investigated the effect of protease inhibitors specifically on visceral sensitivity while their effect on inflammation is described in more detail. In our accompanying review we describe their effect on gastrointestinal permeability. On account of their promising results in the field of visceral hypersensitivity, further research is warranted. The aim of this review is to give an overview on the concept of visceral hypersensitivity as well as on the physiological and pathophysiological functions of proteases herein. | Hannah Ceuleers Hanne Van Spaendonk Nikita Hanning Jelena Heirbaut Anne-Marie Lambeir Jurgen Joossens Koen Augustyns Joris G De Man Ingrid De Meester Benedicte Y De Winter | 2016 | World Journal of Gastroenterology2016，22，47： | 7 |
| 2 | Regulation of intestinal permeability: The role of proteases显示文摘The gastrointestinal barrier is-with approximately 400 m^2-the human body's largest surface separating the external environment from the internal milieu. This barrier serves a dual function: permitting the absorption of nutrients, water and electrolytes on the one hand, while limiting host contact with noxious luminal antigens on the other hand. To maintain this selective barrier, junction protein complexes seal the intercellular space between adjacent epithelial cells and regulate the paracellular transport. Increased intestinal permeability is associated with and suggested as a player in the pathophysiology of various gastrointestinal and extraintestinal diseases such as inflammatory bowel disease, celiac disease and type 1 diabetes. The gastrointestinal tract is exposed to high levels of endogenous and exogenous proteases, both in the lumen and in the mucosa. There is increasing evidence to suggest that a dysregulation of the protease/antiprotease balance in the gut contributes to epithelial damage and increased permeability. Excessive proteolysis leads to direct cleavage of intercellular junction proteins, or to opening of the junction proteins via activation of protease activated receptors. In addition, proteases regulate the activity and availability of cytokines and growth factors, which are also known modulators of intestinal permeability. This review aims at outlining the mechanisms by which proteases alter the intestinal permeability. More knowledge on the role of proteases in mucosal homeostasis and gastrointestinal barrier function will definitely contribute to the identification of new therapeutic targets for permeability-related diseases. | Hanne Van Spaendonk Hannah Ceuleers Leonie Witters Eveline Patteet Jurgen Joossens Koen Augustyns Anne-Marie Lambeir Ingrid De Meester Joris G De Man Benedicte Y De Winter | 2017 | World Journal of Gastroenterology2017，23，12： | 6 |
| 3 | 消减食品加工过程中的真菌毒素:来自欧洲和东南亚的经验分享显示文摘在世界范围内,由真菌毒素造成的经济损失估计达数十亿美元,给人类和动物带来安全风险。粮食中真菌毒素的预防可以通过食品加工过程中进行真菌毒素的消减处理。在过去几十年里,虽然发表的科技论文中报道了大量真菌毒素防控措施,但实际生产往往需要更容易实施的、简单易行的建议和指导方针。欧洲和东南亚在真菌毒素处理到数据分析、风险评估到污染防控、差异分析到流通途径等方面可以做到相互协作,互相补充。欧洲和东南亚政府及相关行业必须在综合考虑地域、农业系统和不同国家消费者偏好的背景下,寻求平衡食品安全和地区贸易二者关系,协同管控食品供应链。以谷物为例,加工过程包括初级加工(谷物清理和碾磨操作)和二次加工(如烘焙过程中的发酵和烘烤),欧洲尤其关注烘焙食品安全性及全麦面包生产工艺对呕吐毒素的影响。结合农业、咖啡工业和科学研究人员的专业知识及亚洲咖啡生产者的具体情况,重点关注东南亚地区咖啡中赭曲霉毒素A污染问题。在农场环境中减少真菌毒素的措施给咖啡农民带来了较大的挑战,包括在规范种植农场模式下咖啡生产者和消费者之间社会经济效益和个人行为模式的相关影响因素。随着世界变得更加全球化,食品和饲料供应链也变得日趋复杂,因此,需要制定更全面的策略来确保食品供给及品质安全。 | Paula Alvito Jonathan Barcelo Johan De Meester Elias Rito Michele Suman | 2021 | 粮油食品科技2021，29，6： | 3 |
| 4 | Microstructure, local and global mechanical properties of friction stir welds in aluminium alloy 6005A-T6显示文摘 | A. Simar Y. Bréchet B. de Meester A. Denquin T. Pardoen | 2007 | Materials Science & Engineering A2007，，1： | 2 |
| 5 | Toxicity of doxorubicin entrapped within long-circulating liposomes 显示文摘 | Daemen T Regts J Meesters M | 1997 | J Control Release1997，44，： | 1 |
| 6 | Daphnia species diversity in Kenya, and a key to the identification of their ephippia显示文摘 | Mergeay J Verschuren D De Meester L | 2005 | Hydrobiologia2005，542，： | 1 |
| 7 | The influence of food quality on the phototaetie behavior of Daphnia magna straus显示文摘 | Michels E De Meester L 1998 | 1998 | Hydrobiologia1998，379，： | 1 |
| 8 | Stability of fluorinated surfactants in advanced oxidation processes-A follow up of degradation products using flow injection-mass spectrometry,liquid chromatography-mass spectrometry and liquid chromatography-multiple stage mass spectrometry显示文摘 | SCHRODER H FR MEESTERS R J W | 2005 | Journal of Chromatography A2005，，： | 1 |
| 9 | Structural characterization of bis ( L - methionato ) zinc ( Ⅱ), Zn (met) 2 显示文摘 | WILSON R B MEESTER P D HODGSON D J | 1997 | Inory Chem1997，16，6： | 1 |
| 10 | Comparison between adenoviral and retroviral vectors for the transduction of the thymidine kinase PET reporter gene in rat mesenchymal stem cells显示文摘 | Roelants V Labar D de Meester C | | 0，，11： | 1 |
| 11 | Microstructure, local and global mechanical properties of friction stir welds in aluminium alloy 6005A-T6显示文摘 | A. Simar Y. Bréchet B. de Meester A. Denquin T. Pardoen | 2007 | Materials Science & Engineering A2007，，1： | 1 |
| 12 | Coronary artery atherosclerosis:severity of the disease,severity of angina pectoris and compromised left ventricular function显示文摘 | DM Leaman RW Brower GT Meester | 1981 | Circu- lation1981，63，： | 1 |
| 13 | High-eell-density cuhiva- tion of the lipid accumulating yeast Cr)ptococcus curattts using glycerol as a carbon source 显示文摘 | Meesters P Huijberts G Eggink G | 1996 | Appl Mierobiol Bioteehnol1996，45，5： | 1 |
| 14 | Role of AMP-activated protein kinase in regulating hypoxic survival and proliferation of mesenchymal stem cells显示文摘 | DE MEESTER C TIMMERMANS AD BALTEAU M | 2014 | Cardiovasc Res2014，101，1： | 1 |
| 15 | Non-ablative 1,550 nm fractional laser therapy versus triple topical therapy for the treatment of melasma: a randomized controlled split-face study 显示文摘 | Wind BS Kroon MW Meesters AA | 2010 | Lasers Surg Med2010，42，7： | 1 |
| 16 | Ultra-sonic nebulizers as a potential source of methicillin-resistant Staphylococcus aureus causing an outbreak in a university tertiary care hospital 显示文摘 | Schuhz C Meester HH Kranenburg AM | 2003 | J Hosp Infect2003，55，4： | 1 |
| 17 | Characterization of β-lactamase enzyme activity in bacterial lysates using MALDI-mass spectrometry显示文摘 | HOOFF GP VAN KAMPEN JJ MEESTERS RJ | 2012 | J Proteome Res2012，11，1： | 1 |
| 18 | Sequential modeling of local precipitation, strength andstrain hardening in friction stir welds of an aluminumalloy 6005A-T6显示文摘 | SIMAR A BRéCHET Y de MEESTER B | 2007 | Acta Materialia2007，55，18： | 1 |
| 19 | Psych-ometric evaluation of the OM8-30 questionnaire in Dutch children with otitis media 显示文摘 | Timmerman AA Meesters CM Anteunis LJ | 2008 | Eur Arch Otorhinolaryngol2008，265，9： | 1 |
| 20 | Influenceof yield strength and toughness on friction and wear ofpolycarbonate显示文摘 | Mergler Y J van Kampen R J Nauta W J Schaake R P Raas B van Griensven J G H Meesters C J M | 2005 | Wear2005，258，56： | 1 |
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