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| 1 | Antimicrobial susceptibility testing for Helicobacter pylori in times of increasing antibiotic resistance显示文摘The gram-negative bacterium Helicobacter pylori(H.pylori)causes chronic gastritis,gastric and duodenal ulcers,gastric cancer and mucosa-associated lymphoid tissue lymphoma.Treatment is recommended in all symptomatic patients.The current treatment options for H.pylori infection are outlined in this review in light of the recent challenges in eradication success,largely due to the rapid emergence of antibiotic resistant strains of H.pylori.Antibiotic resistance is a constantly evolving process and numerous studies have shown that the prevalence of H.pylori antibiotic resistance varies significantly from country to country,and even between regions within the same country.In addition,recent data has shown that previous antibiotic use is associated with harbouring antibiotic resistant H.pylori.Local surveillance of antibiotic resistance is warranted to guide clinicians in their choice of therapy.Antimicrobial resistance is assessed by H.pylori culture and antimicrobial susceptibility testing.Recently developed molecular tests offer an attractive alternative to culture and allow for the rapid molecular genetic identification of H.pylori and resistance-associated mutations directly from biopsy samples or bacterial culture material.Accumulating evidence indicates that surveillance of antimicrobial resistance by susceptibility testing is feasible and necessary to inform clinicians in their choice of therapy for management of H.pylori infection. | Sinéad M Smith Colm O’Morain Deirdre McNamara | 2014 | World Journal of Gastroenterology2014，20，29： | 40 |
| 2 | Molecular detection of Helicobacter pylori antibiotic resistance in stool vs biopsy samples显示文摘AIM To compare(1) demographics in urea breath test(UBT) vs endoscopy patients; and(2) the molecular detection of antibiotic resistance in stool vs biopsy samples.METHODS Six hundred and sixteen adult patients undergoing endoscopy or a UBT were prospectively recruited to the study. The Geno Type Helico DR assay was used to detect Helicobacter pylori(H. pylori) and antibiotic resistance using biopsy and/or stool samples from CLOpositive endoscopy patients and stool samples from UBT-positive patients. RESULTS Infection rates were significantly higher in patients referred for a UBT than endoscopy(overall rates: 33% vs 19%; treatment-na?ve patients: 33% vs 14.7%, respectively). H. pylori-infected UBT patients were younger than H. pylori-infected endoscopy patients(41.4 vs 48.4 years, respectively, P < 0.005), with a higher percentage of H. pylori-infected males in the endoscopy-compared to the UBT-cohort(52.6% vs 33.3%, P = 0.03). The Geno Type Helico DR assay was more accurate at detecting H. pylori infection using biopsy samples than stool samples [98.2%(n = 54/55) vs 80.3%(n =53/66), P < 0.005]. Subset analysis using stool and biopsy samples from CLO-positive endoscopy patients revealed a higher detection rate ofresistance-associated mutations using stool samples compared to biopsies. The concordance rates between stool and biopsy samples for the detection of H. pylori DNA, clarithromycin and fluoroquinolone resistance were just 85%, 53% and 35%, respectively. CONCLUSION Differences between endoscopy and UBT patients provide a rationale for non-invasive detection of H. pylori antibiotic resistance. However, the Geno Type Helico DR assay is an unsuitable approach. | Denise E Brennan Joseph Omorogbe Mary Hussey Donal Tighe Grainne Holleran Colm O'Morain Sinéad M Smith Deirdre McNamara | 2016 | World Journal of Gastroenterology2016，22，41： | 6 |
| 3 | Can bacterial virulence factors predict antibiotic resistant Helicobacter pylori infection?显示文摘AIM To evaluate the association between virulence factor status and antibiotic resistance in Helicobacter pylori(H. pylori)-infected patients in Ireland. METHODS DNA was extracted from antral and corpus biopsies obtained from 165 H. pylori-infected patients. Genotyping for clarithromycin and fluoroquinolone-mediating mutations was performed using the Genotype Helico DR assay. cag A and vac A genotypes were investigated using PCR. RESULTS Primary, secondary and overall resistance rates for clarithromycin were 50.5%(n = 53/105), 78.3%(n = 47/60) and 60.6%(n = 100/165), respectively. Primary, secondary and overall resistance rates for fluoroquinolones were 15.2%(n = 16/105) and 28.3%(n = 17/60) and 20%(n = 33/165), respectively. Resistance to both antibiotics was 12.4%(n = 13/105) in treatment-na?ve patients, 25%(n = 15/60) in those previously treated and 17%(n = 28/165) overall. A cag A-positive genotype was detected in 22.4%(n = 37/165) of patient samples. The dominant vac A genotype was S1/M2 at 44.8%(n = 74/165), followed by S2/M2 at 26.7%(n = 44/165), S1/M1 at 23.6%(n = 39/165) and S2/M1 at 4.8%(n = 8/165). Primary clarithromycin resistance was significantly lower in cag A-positive strains than in cag A-negative strains [32%(n = 8/25) vs 56.3%(n = 45/80); P = 0.03]. Similarly, in patients infected with more virulent H. pylori strains bearing the vac A s1 genotype, primary clarithromycin resistance was significantly lower than in those infected with less virulent strains bearing the vac A s2 genotype, [41%(n = 32/78) vs 77.8%(n = 21/27); P = 0.0001]. No statistically significant association was found between primary fluoroquinolone resistance and virulence factor status.CONCLUSION Genotypic H. pylori clarithromycin resistance is high and cag A-negative strains are dominant in our population. Less virulent(cag A-negative and vac A S2-containing) strains of H. pylori are associated with primary clarithromycin resistance. | Denise E Brennan Colin Dowd Colm O'Morain Deirdre McNamara Sinéad M Smith | 2018 | World Journal of Gastroenterology2018，24，9： | 4 |
| 4 | 血管紧张素Ⅱ1型受体基因多态性与心力衰竭预后的相关性研究显示文摘目的评价血管紧张素Ⅱ1型受体(AngiotensinⅡtype 1 receptor,AT1R)基因1166位点A/C基因多态性对心力衰竭预后的影响。方法432例患者来源于美国匹兹堡大学医疗中心的心血管事件基因危险性评价研究组,均有收缩功能障碍性心力衰竭〔射血分数(EF)<0.45〕。入选时间为1996年4月至2001年1月,前瞻性随访患者(26.43±18.19)月,随访终点是死亡或心脏移植。用聚合酶链式反应(PCR)方法鉴定AT1R基因A1166C位点基因型,分析AT1R A1166C基因多态性对心力衰竭患者生存率的影响。结果AT1R纯合子CC型8.6%,纯合子AA型50.0%,杂合子AC型41.4%。三组基因型在年龄、性别、种族、病因、血压和治疗方面无显著性差异,而在NYHA心功能分级的比例有显著性差异,AT1R C等位基因与较低心功能分级密切相关(P=0.04),但随访三组基因型的三年生存率并无显著性差异。结论在本组收缩功能障碍性心力衰竭患者中,AT1R C等位基因仅与较低心功能分级密切相关,并不影响未行心脏移植心力衰竭患者的预后。 | 郑茵 方壮伟 吴智勇 Barry London Dennis M McNamara | 2005 | 中国心血管杂志2005，10，6： | 3 |
| 5 | Magnetic resonance imaging with respiratory gating: techniques and advantages显示文摘 | Ehman RL McNamara MT Pallack M | 1984 | AJR1984，143，6： | 1 |
| 6 | Evolutionarily stable levels of vigilance as a function of group size 显示文摘 | MCNAMARA J M HOUSTON A I | 1992 | Animal Behaviour1992，43，： | 1 |
| 7 | Pharmacogenetic interactions between beta-blocker therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure显示文摘 | MCNAMARA D M HOLUBKOV R JANOSKO K | 2001 | Circulation2001，103，： | 1 |
| 8 | Emergence of MRSA in positive blood cultures from patients with febrile neutropenia -a cause for concern显示文摘 | Morris PG Hassan T McNamara M | 2008 | Support Care Cance2008，16，9： | 1 |
| 9 | Biomechannical analysis of three surgical approaches for lumbar burst factures using short-segment instrumentation显示文摘 | Gurwitz GS Dawson J M Mcnamara MJ | 1993 | Spine1993，18，： | 1 |
| 10 | The effect of the Talking Diabetes consulting skills intervention on glycaemic control and quality of life in children with type 1 diabetes : cluster randomised controlled trial( DEPICTED study) 显示文摘 | ROBLING M MCNAMARA R BENNERT K | 2012 | BMJ2012，344，： | 1 |
| 11 | Obesity as an inde- pendent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study 显示文摘 | Hubert HB Feinleib M McNamara PM | 1983 | Circulation1983，67，5： | 1 |
| 12 | Benchscale removal of odor and volatile organic compounds at a composting facility显示文摘 | Van Durme G P McNamara B F McGinley C M | 1992 | Water Environ Res1992，64，1： | 1 |
| 13 | Quantification of penicillinG and procaine in equine urine and plasma using high-performance liquid chromatography显示文摘 | Luo Y McNamara B Fennell M A | 1998 | J Chromatogr B1998，714，2： | 1 |
| 14 | Pharmacogenetic interactions between angiotensin-converting enzyme inhibitor therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure显示文摘 | MCNAMARA D M HOLUBKOV R POSTAVA L | 2004 | J Am Coll Cardiol2004，44，： | 1 |
| 15 | AMPD1 gene mutation in congestire heart failure: New insights imo the patho-biology of disease progression显示文摘 | Feldman A M Wagner D R McNamara D M | 1999 | Circulation1999，99，11： | 1 |
| 16 | The use of high resolution melting (HRM) to map single nucleotide polymorphism markers linked to a covered smut resistance gene in barley 显示文摘 | Lehmensiek A Sutherland M W McNamara R B | 2008 | Theor Appl Genet2008，117，5： | 1 |
| 17 | Spatial variation and temporal stability of soil water in a snow-dominated, mountain catchment 显示文摘 | Grant L Seyfried M McNamara J | 2004 | Hydrological Processes2004，18，18： | 1 |
| 18 | Evaluation of diamond films by nuclear magnetic resonance and Raman spectroscopy 显示文摘 | McNamara K M Gleason K K Vestyck D J | 1992 | Diamond and Related Materials1992，1，： | 1 |
| 19 | Obesity as an independent risk for cardiovascular disease:a 26 year follow up of participants in Framingham heart study显示文摘 | Hubert HB Feinlei M McNamara PM et a1 | 1983 | Circu1ation1983，67，5： | 1 |
| 20 | Obesity as an independent risk factor for cardiovascular disease:a 26-year follow-up of participants in the Framingham Heart Study显示文摘 | Hubert HB Feinleib M McNamara PM | 1983 | Circulation1983，67，： | 1 |
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