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| 1 | Autophagy in mammalian cells显示文摘Autophagy is a regulated process for the degradation of cellular components that has been well conserved in eukaryotic cells. The discovery of autophagy-regulating proteins in yeast has been important in understanding this process. Although many parallels exist between fungi and mammals in the regulation and execution of autophagy, there are some important differences. The preautophagosomal structure found in yeast has not been identified in mammals, and it seems that there may be multiple origins for autophagosomes, including endoplasmic reticulum, plasma membrane and mitochondrial outer membrane. The maturation of the phagophore is largely dependent on 5'-AMP activated protein kinase and other factors that lead to the dephosphorylation of mammalian target of rapamycin. Once the process is initiated, the mammalian phagophore elongates and matures into an autophagosome by processes that are similar to those in yeast. Cargo selection is dependent on the ubiquitin conjugation of protein aggregates and organelles and recognition of these conjugates by autophagosomal receptors. Lysosomal degradation of cargo produces metabolites that can be recycled during stress. Autophagy is an impor-tant cellular safeguard during starvation in all eukaryotes; however, it may have more complicated, tissue specific roles in mammals. With certain exceptions, autophagy seems to be cytoprotective, and defects in the process have been associated with human disease. | Kadija Abounit Tiziano M Scarabelli Roy B McCauley | 2012 | World Journal of Biological Chemistry2012，3，1： | 18 |
| 2 | Immune mediators in the tumor microenvironment of prostate cancer显示文摘Prostate cancer tissue is composed of both cancer cells and host cells.The milieu of host components that compose the tumor is termed the tumor microenvironment(TME).Host cells can be those derived from the tissue in which the tumor originates(e.g.,fibroblasts and endothelial cells)or those recruited,through chemotactic or other factors,to the tumor(e.g.,circulating immune cells).Some immune cells are key players in the TME and represent a large proportion of non-tumor cells found within the tumor.Immune cells can have both anti-tumor and pro-tumor activity.In addition,crosstalk between prostate cancer cells and immune cells affects immune cell functions.In this review,we focus on immune cells and cytokines that contribute to tumor progression.We discuss T-regulatory and T helper17 cells and macrophages as key modulators in prostate cancer progression.In addition,we discuss the roles of interleukin-6 and receptor activator of nuclear factor kappa-B ligand in modulating prostate cancer progression.This review highlights the concept that immune cells and cytokines offer a potentially promising target for prostate cancer therapy. | Jinlu Dai Yi Lu Hernan Roca Jill M. Keller Jian Zhang Laurie K. McCauley Evan T. Keller | 2017 | Chinese Journal of Cancer2017，36，3： | 6 |
| 3 | 支气管哮喘患者心脏性猝死与吸入性β激动剂的关系显示文摘β激动剂吸入后,可引起心功能的特异性改变,支气管哮喘患者死亡率的增加可能与β激动剂的使用有关。 | Robin E D McCauley R 朱亚玲 | 1993 | 国外医学(呼吸系统分册)1993，13，2： | 4 |
| 4 | Targeting ryanodine receptors for anti-arrhythmic therapy显示文摘Antiarrhythmic 药是压制或阻止反常的心节奏的一组药品,它经常与实质的病态和死亡被联系。典型地指向血浆膜离子隧道的当前的 antiarrhythmic 药限制了临床的成功,在一些,情况被描述了为是支持 arrhythmic。然而,最近的研究建议钙的那个病理学的版本(从经由心脏的 ryanodine 受体(RyR2 ) 的 sarcoplasmic 蜂窝胃的 Ca 2+) 能为 antiarrhythmic 代表一个有希望的目标治疗。心脏舒张的 SR Ca 2+ 版本在两个被连接了到 arrhythmogenesis 继承心律不齐症候群“ catecholaminergic 多态的室的心悸亢进”并且心疾病的获得的形式(例如, atrial 纤维性颤动,心失败) 。药品的几个班被显示了减少反常 RyR2 活动并且可以通过 SR Ca 2+ 漏缝的减小对触发的心律不齐授与保护。在这评论,我们将为稳定 RyR2 评估当前的药理学方法并且基于分子的机制的当前的证据建议处理形式。 | Mark D McCAULEY | 2011 | Acta Pharmacologica Sinica2011，32，6： | 3 |
| 5 | Geographic Spread of Currency Trading:The Renminbi and Other Emerging Market Currencies显示文摘This paper studies the ongoing diffusion of renminbi (RMB) trading across the globe, the first of such research of an international currency. It analyses the distribution in offshore RMB trading in 2013 and 2016 using comprehensive data from the Triennial Central Bank Survey of foreign exchange markets. In 2013, Asian centers favored by the policy of RMB internationalization had disproportionate shares in global RMB trading. Over the following three years, RMB trading seemed to converge to the spatial pattern of all currencies, with a half-life of seven to eight years. The previously most traded emerging market currency, the Mexican peso, shows a similar pattern, although it is converging to the global norm more slowly. Three other emerging market currencies show a qualitatively similar evolution in the geography of their offshore trading. Overall, the RMB's internationalization is tracing an arc from the influence of administrative measures to the working of market forces. | Yin-Wong Cheung Robert N McCauley Chang Shu | 2019 | China & World Economy2019，27，5： | 3 |
| 6 | Municipal solid waste composition studies显示文摘 | MCCAULEY BELL REINHART D SEIR H | 1997 | ASCE Practice Periodical of Hazardous and Radioactive Waste1997，1，4： | 2 |
| 7 | Enrichment of retinal ganglion and Müller glia progenitors from retinal organoids derived from human induced pluripotent stem cells-possibilities and current limitations显示文摘BACKGROUND Retinal organoids serve as excellent human-specific disease models for conditions affecting otherwise inaccessible retinal tissue from patients.They permit the isolation of key cell types affected in various eye diseases including retinal ganglion cells(RGCs)and Müller glia.AIM To refine human-induced pluripotent stem cells(hiPSCs)differentiated into threedimensional(3D)retinal organoids to generate sufficient numbers of RGCs and Müller glia progenitors for downstream analyses.METHODS In this study we described,evaluated,and refined methods with which to generate Müller glia and RGC progenitors,isolated them via magnetic-activated cell sorting,and assessed their lineage stability after prolonged 2D culture.Putative progenitor populations were characterized via quantitative PCR and immunocytochemistry,and the ultrastructural composition of retinal organoid cells was investigated.RESULTS Our study confirms the feasibility of generating marker-characterized Müller glia and RGC progenitors within retinal organoids.Such retinal organoids can be dissociated and the Müller glia and RGC progenitor-like cells isolated via magnetic-activated cell sorting and propagated as monolayers.CONCLUSION Enrichment of Müller glia and RGC progenitors from retinal organoids is a feasible method with which to study cell type-specific disease phenotypes and to potentially generate specific retinal populations for cell replacement therapies. | Kristine Karla Freude Sarkis Saruhanian Alanna McCauley Colton Paterson Madeleine Odette Annika Oostenink Poul Hyttel Mark Gillies Henriette Haukedal Miriam Kolko | 2020 | World Journal of Stem Cells2020，12，10： | 2 |
| 8 | Primary idiopathic chylopericardium显示文摘 | OSSIANI M MCCAULEY R PATEL H | 2003 | Pediatr Radiol2003，33，： | 1 |
| 9 | Initiation and progression of axonopathy in experimental autoimmune encephalomyelitis显示文摘 | Soulika AM Lee E McCauley E | 2009 | J Neurosci2009，29，14： | 1 |
| 10 | Sediment quality guidelines and assessment: over and research needs 显示文摘 | McCauley D J De Grave G M Linton T K | 2000 | Environmental Sciences and Policy2000，3，： | 1 |
| 11 | Parent-childinteractions,peripheral serotonin,and self-inflicted injury inadolescents显示文摘 | Crowell SE’Beauchaine TP McCauley Ky | 2008 | J Consult Clin Psychol2008，76，1： | 1 |
| 12 | Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102 显示文摘 | Sennino B Falcon BL McCauley D | 2007 | Cancer Res2007，67，15： | 1 |
| 13 | Historical perspective and contribution of US researchers into the field of self-propagating high-temperature synthesis (SHS)/combustion synthesis (CS):personal reflections显示文摘 | McCauley J W Puszynski J A | 2008 | International Journal of Self-Propagating High-Temperature Synthesis2008，17，： | 1 |
| 14 | Effects of hormones and cytokiues on stimulation of adenylate cyclase and intracellur calcium concentration in human and canine periodontal-ligament fibroblasts显示文摘 | Nohutcu RM Mccauley LK | 1993 | Arch Oral Bio1993，38，10： | 1 |
| 15 | Magnetic resonance diag nosis of meniscal tears in patients with acute medial collateral lig- ment tears显示文摘 | Jee WH McCauley TR Kim JM | 2004 | J Comput Assist Tomogr2004，28，3： | 1 |
| 16 | Current strategies in the diagnosis and treatment of childhood attention deficit hy- peractivity disorder 显示文摘 | Rader R McCauley L Callen EC | 2009 | Am Fam Physician2009，79，8： | 1 |
| 17 | Creating urban classroom com- munities worthy of trust 显示文摘 | Ennis CD McCauley MT | 2002 | Journal of Curriculum Stud- ies2002，34，2： | 1 |
| 18 | Regulation of SDF-1 (CXCL12) production by osteoblasts; a possible mechanism for stem cell homing显示文摘 | Y. Jung J. Wang A. Schneider Y.-X. Sun A.J. Koh-Paige N.I. Osman L.K. McCauley R.S. Taichman | 2005 | Bone2005，，4： | 1 |
| 19 | Computed tomography of bronchiectasis 显示文摘 | Naidich DP Mccauley DI Khouri NF | 1982 | J Comput Assist Tomogr1982，6，3： | 1 |
| 20 | 欧洲美元银行业务及货币国际化显示文摘众所周知,诸如中国人民币这样的顺差国货币是无法在全球通用的。我们认为欧洲美元市场对于净资本流动方向以及美国经常账目平衡影响甚微。在过去38年中,欧洲美元市场扮演的最重要角色是作为非美国居民使用美元的中间媒介。通过研究欧洲美元市场.我们可以预测人民币离岸市场的演变。尽管现在,人民币离岸市场还只是作为国外通向中国大陆的资金管道,但是在未来,这个市场同样可以在非中国居民间起到中介作用。 | 何东 Robert McCauley | 2012 | 金融发展评论2012，，8： | 1 |
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