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| 1 | Impact of alcohol on hepatitis C virus replication and interferon signaling显示文摘Hepatitis C virus (HCV) is one of the main etiological factors responsible for liver disease worldwide. It has been estimated that there are over 170 million people infected with HCV worldwide. Of these infected individuals, approximately 75% will go on to develop a life long necroinflammatory liver disease, which over decades, can result in serious complications, such as cirrhosis and hepatocellular carcinoma. Currently there is no effective vaccine and whilst antiviral therapies have been improved, they are still only effective in approximately 50% of individuals. HCV infection stands as a major cause of global morbidity and suffering, and places a signifi cant burden on health systems. The second highest cause of liver disease in the western world is alcoholic liver disease. Frequently, HCV infected individuals consume alcohol, and the combined effect of HCV and alcohol consumption is deleterious for both liver disease and response to treatment. This review discusses the impact of alcohol metabolism on HCV replication and the negative impact on interferon (IFN)-α treatment, with a particular focus on how alcohol and HCV act synergistically to increase oxidative stress, ultimately leading to exacerbated liver disease and a reduction in the effi cacy of IFN-α treatment. A better understanding of the complicated mechanisms at play in hepatocytes infected with HCV and metabo- lizing alcohol will hopefully provide better treatment options for chronic hepatitis C individuals that consume alcohol. | Erin M McCartney Michael R Beard | 2010 | World Journal of Gastroenterology2010，16，11： | 5 |
| 2 | A comparison of the abrasive wear behaviour of HVOF sprayed titanium carbide- and titanium boride-based cermet coatings显示文摘 | M Jones A.J Horlock P.H Shipway D.G McCartney J.V Wood | 2001 | Wear2001，，1： | 3 |
| 3 | Mapping of three antigenic sites on the hemagglutinin-neuraminidase protein of Newcastle disease virus显示文摘 | YusoffK Nesbit M McCartney H | 1988 | Virus Res1988，11，： | 1 |
| 4 | Location of neutralizing epitopes on the fusion protein of Newcastle disease virus strain Beaudette C 显示文摘 | YUSOFF K NESBIT M MCCARTNEY H | 1989 | J Gen Virol1989，70，： | 1 |
| 5 | Magnetic microstructure of magnetotactic bacteria by electron holography显示文摘 | Dunin R E McCartney M R Frankel R B | 1998 | Science1998，282，： | 1 |
| 6 | Dynamics of usangu plains wetlands: use of remote sensing and GIS as management decision tools 显示文摘 | KASHAIGILI J J MBILINYI B P MCCARTNEY M et a l | 2006 | Physics and Chemistry of the Earth2006，31，1516： | 1 |
| 7 | An Exit-Flow Model Used in Dynamic Traffic Assignment显示文摘 | CAREY M MCCARTNEY M | 2004 | Computers Operations Research2004，31，10： | 1 |
| 8 | Prebiotic effects: metabolic and health benefits显示文摘 | Roberfroid M Gibson G R Hoyles L McCartney A L Rastall R Rowland I Wolvers D Watztl B Szajewska H Stahl B Guarner F Respondek F Whelan K Coxam V Davieco M Laotoing L Wittrant Y Delzenne N Cani P Neyrinek A Meheust A | 2010 | British Journal of Nutrition2010，104，2： | 1 |
| 9 | A whole-link travel-time model with desirable properties 显示文摘 | CAREY M GE Ying-en MCCARTNEY M | 2003 | Transportation Science2003，37，1： | 1 |
| 10 | TLR7/9 versus TLR3/ MDA5 signaling during virus i~ections and diabetes显示文摘 | Swiecki M McCartney SA Wang Y | 2011 | J Leukoc Biol2011，90，4： | 1 |
| 11 | Behaviour of a Whole-link Travel-time Model Used in Dynamic Ttraffic Assignment显示文摘 | Carey M McCartney M | 2002 | Transportation Research2002，36，1： | 1 |
| 12 | Pseudo-periodicity in a Travel-time Model Used in Dynamic Traffic Assignment显示文摘 | Carey M McCartney M | 2002 | Transportation Research2002，37，9： | 1 |
| 13 | Advances in PTC thermistor technology 显示文摘 | McCartney J H Casselton R E W Morter C M | 1991 | Br Ceram Proc1991，50，： | 1 |
| 14 | Behaviour of a WholeLink Travel-Time Model Used in Dynamic Traffic Assignment显示文摘 | CAREY M MCCARTNEY M | 2002 | Transportation Research2002，36，1： | 1 |
| 15 | Glucocorticoid-induced formation of cross-linked actin networks in cultured human trabecular meshwork cells显示文摘 | Clark AF Wilson K McCartney MD Miggans ST Kunkle M Howe W | | 0，，01： | 1 |
| 16 | An Exit-flow Model Used in Dynamic Traffic Assignment显示文摘 | Carey M McCartney M | 2004 | Computers & Operations Research2004，31，10： | 1 |
| 17 | Pseudo-Periodicity in a Travel-Time Model Used in Dynamic Traffic Assignment显示文摘 | CAREY M MCCARTNEY M | 2003 | Transportation Research2003，37，9： | 1 |
| 18 | Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila 显示文摘 | McCartney B M Price M H Webb R L | 2006 | Development2006，133，12： | 1 |
| 19 | Competition between methanogens and sulfate reduces: Effect of COD: sulfate ratio and acclimatization 显示文摘 | McCARTNEY D M OLESKIEWICZ J A | 1993 | Wat Env Res1993，65，1： | 1 |
| 20 | Random ised controlled trial of weightlifting exercise in patients with chronic airflow limitation显示文摘 | SIMPSON K KILLIAN K MCCARTNEY M | 1992 | Thorax1992，，2： | 1 |
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