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| 1 | Diabetic cardiomyopathy: Pathophysiology, theories and evidence to date显示文摘The prevalence of type 2 diabetes(T2D)has increased worldwide and doubled over the last two decades.It features among the top 10 causes of mortality and morbidity in the world.Cardiovascular disease is the leading cause of complications in diabetes and within this,heart failure has been shown to be the leading cause of emergency admissions in the United Kingdom.There are many hypotheses and well-evidenced mechanisms by which diabetic cardiomyopathy as an entity develops.This review aims to give an overview of these mechanisms,with particular emphasis on metabolic inflexibility.T2D is associated with inefficient substrate utilisation,an inability to increase glucose metabolism and dependence on fatty acid oxidation within the diabetic heart resulting in mitochondrial uncoupling,glucotoxicity,lipotoxicity and initially subclinical cardiac dysfunction and finally in overt heart failure.The review also gives a concise update on developments within clinical imaging,specifically cardiac magnetic resonance studies to characterise and phenotype early cardiac dysfunction in T2D.A better understanding of the pathophysiology involved provides a platform for targeted therapy in diabetes to prevent the development of early heart failure with preserved ejection fraction. | Lavanya Athithan Gaurav S Gulsin Gerald P McCann Eylem Levelt | 2019 | World Journal of Diabetes2019，10，10： | 15 |
| 2 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 3 | Obesity is associated with macrophage accumulation in adipose tissue显示文摘 | MCCANN D DESAI M | 2003 | J Clin Invest2003，112，12： | 1 |
| 4 | Dietary lignin intakes and risk of pre and postmenopausal dreast cancer显示文摘 | Mccann S E Muti P Vtto D | 2004 | Int Cncer2004，11，3： | 1 |
| 5 | Stimulatory and inhibitory effects of purified hypothalamic extracts on growth hormone release from rat pituitary in vitro显示文摘 | Krulich L Dhariwal A P McCann S M | 1968 | Endocrinology1968，83，4： | 1 |
| 6 | The structure and evolution of industrial clusters: Transactions, technology and knowl- edge spillovers 显示文摘 | IAMMARINO S MCCANN P | 2006 | Research Policy2006，，35： | 1 |
| 7 | The structure and evolution of in- dustrial clusters : transactions, technology, and knowledge spillovers 显示文摘 | Iammarino S McCann P | 2006 | Research Policy2006，35，： | 1 |
| 8 | Quantitative Studies in Retinex Theory:A Comparison between Theoretical Predictions and Observer Responses to the 'Color Mondrian' Experiments显示文摘 | McCann J J McKee S P Taylor T H | 1978 | Vision Research1978，16，5： | 1 |
| 9 | The relationship between estimated glomerular filtration rate and thyroid function: an observational study显示文摘 | Woodward A McCann S Al-Jubouri M | 2008 | Ann Clin Biochem2008，45，5： | 1 |
| 10 | Prospective evaluation of a Dacron cuffed hemodialysis catheter for prolonged use 显示文摘 | Schwab S Buller G Mccann R | 1988 | Am J Kidney Dis1988，11，2： | 1 |
| 11 | Do cytokeratin positive only sentinel lymph nodes warrant complete axillary lymph node dissection in patients with invasive breast cancer? 显示文摘 | Teng S Dupont E McCann C | 2000 | Am Surg2000，66，6： | 1 |
| 12 | Measurement of urinary free cortisol using liquid chromatography-tandem mass spectrometry:comparison with the urine adapted ACS:180 serum cortisol chemiluminescent immunoassay and development of a new reference range显示文摘 | McCann SJ Gillingwater S Keevil BG | 2005 | Ann Clin Biochem2005，42，2： | 1 |
| 13 | Obesity is associated with macrophage accumulation in adipose tissue 显示文摘 | WEISBERG S P MCCANN D DESAI M | 2003 | J Clin Invest2003，112，12： | 1 |
| 14 | Lipopolysaccharide-induced tumor necrosis factor-alpha release is controlled by the central nervous system 显示文摘 | Mastronardi C A Yu W H McCann S | 2001 | Neuroimmunomodulation2001，9，3： | 1 |
| 15 | Distributed stochastic cross-layer optimization for multi-hop wireless networks with cooperative communications显示文摘 | YANG S S SHENG Z G MCCANN J A | 2013 | IEEE Transactions on Mobile Computing2013，13，10： | 1 |
| 16 | Role of leptin in hypothalamic-pituitary function 显示文摘 | Kimura M Walczewska A Karanth S McCann SM | 1997 | Proc Natl Acad Sci USA1997，94，3： | 1 |
| 17 | Osteoprotegerin and osteopontin are expressed at high concentrations within symptomatic carotid atherosclerosis显示文摘 | Golledge J Mccann M Mangan S | 2004 | Stroke2004，35，7： | 1 |
| 18 | Effects of trinexapac-ethyl foliar application on creeping bentgrass responses to combined drought and heat stress显示文摘 | McCann S E Huang B | 2007 | Crop Science2007，47，5： | 1 |
| 19 | The structure of amorphous carbon nitride films using a combined study of NEXAFS,XPS and Raman spectroscopies显示文摘 | Roy S S McCann R Papakonstantinou P | 2005 | Thin Solid Films2005，482，： | 1 |
| 20 | Osteoprotegerin and ostoopontin are expressed at high concentrations within symptomatic carotid atherosclerosis显示文摘 | Goolledge J McCann M Mangan S | 2004 | Stroke2004，35，7： | 1 |
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