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| 1 | Cardiovascular magnetic resonance imaging assessment of outcomes in acute myocardial infarction显示文摘Cardiovascular magnetic resonance(CMR) imaging uniquely characterizes myocardial and microvascular injury in acute myocardial infarction(AMI), providing powerful surrogate markers of outcomes. The last 10 years have seen an exponential increase in AMI studies utilizing CMR based endpoints. This article provides a contemporary, comprehensive review of the powerful role of CMR imaging in the assessment of outcomes in AMI. The theory, assessment techniques, chronology, importance in predicting left ventricular function and remodelling, and prognostic value of each CMR surrogate marker is described in detail. Major studies illustrating the importance of the markers are summarized, providing an up to date review of the literature base in CMR imaging in AMI. | Jamal N Khan Gerry P McCann | 2017 | World Journal of Cardiology2017，9，2： | 16 |
| 2 | Diabetic cardiomyopathy: Pathophysiology, theories and evidence to date显示文摘The prevalence of type 2 diabetes(T2D)has increased worldwide and doubled over the last two decades.It features among the top 10 causes of mortality and morbidity in the world.Cardiovascular disease is the leading cause of complications in diabetes and within this,heart failure has been shown to be the leading cause of emergency admissions in the United Kingdom.There are many hypotheses and well-evidenced mechanisms by which diabetic cardiomyopathy as an entity develops.This review aims to give an overview of these mechanisms,with particular emphasis on metabolic inflexibility.T2D is associated with inefficient substrate utilisation,an inability to increase glucose metabolism and dependence on fatty acid oxidation within the diabetic heart resulting in mitochondrial uncoupling,glucotoxicity,lipotoxicity and initially subclinical cardiac dysfunction and finally in overt heart failure.The review also gives a concise update on developments within clinical imaging,specifically cardiac magnetic resonance studies to characterise and phenotype early cardiac dysfunction in T2D.A better understanding of the pathophysiology involved provides a platform for targeted therapy in diabetes to prevent the development of early heart failure with preserved ejection fraction. | Lavanya Athithan Gaurav S Gulsin Gerald P McCann Eylem Levelt | 2019 | World Journal of Diabetes2019，10，10： | 15 |
| 3 | Global myocardial strain assessment by different imaging modalities to predict outcomes after ST-elevation myocardial infarction:A systematic review显示文摘AIM: To conduct a systematic review relating myocardial strain assessed by different imaging modalities for prognostication following ST-elevation myocardial infarction(STEMI).METHODS: An online literature search was performed in Pub Med and OVID® electronic databases to identify any studies that assessed global myocardial strain parameters using speckle-tracking echocardiography(STE) and/or cardiac magnetic resonance imaging(CMR) techniques [either myocardial tagging or feature tracking(FT) software] in an acute STEMI cohort(days 0-14 post-event) to predict prognosis [either development of major adverse cardiac events(MACE)] or adverse left ventricular(LV) remodelling at follow-up(≥ 6 mo for MACE,≥ 3 mo for remodelling). Search was restricted to studies within the last 20 years. All studies that matched the pre-defined search criteria were reviewed and their results interpreted. Due to considerable heterogeneity between studies,metaanalysis was not performed.RESULTS: A total of seven studies(n = 7) were identified that matched the search criteria. All studies used STE to evaluate strain parameters- five(n = 5) assessed global longitudinal strain(GLS)(n = 5),one assessed GLS rate(GLS-R)(n = 1) and one assessed both(n = 1). Three studies showed that GLS independently predicted the development of adverse LV remodelling by multivariate analysis- odds ratio between 1.19(CI: 1.04-1.37,P < 0.05) and 10(CI: 6.7-14,P < 0.001) depending on the study. Four studies showed that GLS predicted the development of MACE- hazard ratio(HR) between 1.1(CI: 1-1.1,P = 0.006) and 2.34(1.10-4.97,P < 0.05). One paper found that GLS-R could significantly predict MACEHR 18(10-35,P < 0.001)- whilst another showed it did not. GLS <-10.85% had sensitivity/specificity of 89.7%/91% respectively for predicting the development of remodelling whilst GLS <-13% could predict the development of MACE with sensitivity/specificity of 100%/89% respectively. No suitable studies were identified that assessed global strain by CMR tagging or FT techniques.CONCLUSION: GLS measured acutely post-STEMI by STE is a predictor of poor prognosis. Further research is needed to show that this is true for CMR-based techniques. | Abhishek Shetye Sheraz A Nazir Iain B Squire Gerald P McCann | 2015 | World Journal of Cardiology2015，7，12： | 2 |
| 4 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 5 | Obesity is associated with macrophage accumulation in adipose tissue显示文摘 | MCCANN D DESAI M | 2003 | J Clin Invest2003，112，12： | 1 |
| 6 | Dietary lignin intakes and risk of pre and postmenopausal dreast cancer显示文摘 | Mccann S E Muti P Vtto D | 2004 | Int Cncer2004，11，3： | 1 |
| 7 | Stimulatory and inhibitory effects of purified hypothalamic extracts on growth hormone release from rat pituitary in vitro显示文摘 | Krulich L Dhariwal A P McCann S M | 1968 | Endocrinology1968，83，4： | 1 |
| 8 | Rheologic reflection in hypertriglyceridemia-induced pancreatitis 显示文摘 | Martin D McCann E G|ynn P | 2009 | South Med J2009，102，10： | 1 |
| 9 | The structure and evolution of industrial clusters: Transactions, technology and knowl- edge spillovers 显示文摘 | IAMMARINO S MCCANN P | 2006 | Research Policy2006，，35： | 1 |
| 10 | The ecological impact of rural building on habitats in an agricultural landscape显示文摘 | McKenzie P Cooper A McCann T | 2011 | Landscape and Urban Planning2011，101，3： | 1 |
| 11 | Do postoperative platelet - rich plasma injections accelerate early tendon healing and function- al recovery after arthroscopic supraspinatus repair? A randomized controlled trial显示文摘 | Wang A Mccann P Colliver J | 2015 | Am J Sports Med2015，43，6： | 1 |
| 12 | The structure and evolution of in- dustrial clusters : transactions, technology, and knowledge spillovers 显示文摘 | Iammarino S McCann P | 2006 | Research Policy2006，35，： | 1 |
| 13 | Industrial Clusters:Complexes, Ag- glomeration and/or Social Networks? 显示文摘 | Gordon I R McCann P | 2000 | Urban Studies2000，37，3： | 1 |
| 14 | Industrial clusters,transactions costs and the institutional determinants of mne location behavior显示文摘 | MCCANN P ARITA T GORDON I R | | 0，，11： | 1 |
| 15 | Extreme re- verse remodeling in a patient with dilated cardiomyopathy 显示文摘 | Vidic A Mccann P Ramirez Romero JM | 2014 | Circ Heart Fail2014，7，6： | 1 |
| 16 | Human capital, graduate migration and innovation in British regions 显示文摘 | Faggian A McCann P | 2009 | Cambridge Journal of Economics2009，33，2： | 1 |
| 17 | Quantitative Studies in Retinex Theory:A Comparison between Theoretical Predictions and Observer Responses to the 'Color Mondrian' Experiments显示文摘 | McCann J J McKee S P Taylor T H | 1978 | Vision Research1978，16，5： | 1 |
| 18 | Blockade of NKG2D ameliorates disease in mice with collagen-induced arthritis: a potential pathogenic role in chronic inflammatory arthritis 显示文摘 | Andersson A K Sumariwalla P F McCann F E | 2011 | Arthritis Rheum2011，63，9： | 1 |
| 19 | Universities, Agglomerations and Graduate Human Capital Mobility 显示文摘 | Faggian A McCann P | 2009 | Journal of Economic and Social C eogra- phy2009，100，2： | 1 |
| 20 | et al 2002, Industrial clusters, transactions costs and the institutional determinants of MNE location behavior International 显示文摘 | Mccann P | 2002 | Business2002，，11： | 1 |
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