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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | 胸腹主动脉瘤:杂交修复术结果显示文摘目的:胸腹主动脉瘤(TAAA)的治疗依然是外科中最富挑战性的工作,特别是存在退行性变动脉瘤的老年患者同时患肺疾病更是如此。这篇更新后的单中心报道是关于我们对高危TAAA患者采用完全内脏动脉去分支化结合动脉瘤腔内隔绝的杂交修复术经验。方法:从2005年3月—2012年6月间58名患者在单中心接受解剖外内脏血管去分支化及随后的动脉瘤腔内隔绝术。内脏旁路的中位数为4支,最初的33例采用同期手术方式,而最近的25例采用分期手术。结果:患者中位年龄为69.0岁,50%为女性,所有患者存在严重合并症而不适合传统开放修复术。平均主动脉直径(6.7±1.2)cm,30 d/住院病死率、脑卒中率、永久性轻瘫/截瘫率分别为9%、0%以及4%。最近25例分期手术患者的这三种并发症率分别为4%、0%以及0%。平均随访时间(26±21)个月,内脏人工血管通畅率95.3%,所有闭塞的内脏人工血管均为肾动脉,无1例引起永久性截瘫,2例患者需再干预,1例出现Ib型内漏,1例出现III型内漏,5年免于再干预率为94%,Kaplan-Meier总体生存率为1年78%、5年62%,5年主动脉相关生存率为87%。结论:这些更新后的结果 ,继续支撑着这一观点:运用完全内脏动脉去分支联合动脉瘤腔内隔绝的杂交技术治疗高龄且不适合传统开放手术的高危TAAA患者是一种理想的选择,而采取分期手术的方式能取得更佳的结果。 | Gchad Hughes Nicholas D Andersen Jennifer M Hanna Richard L McCann 老启芳 | 2015 | 中国普通外科杂志2015，24，6： | 2 |
| 3 | Obesity is associated with macrophage accumulation in adipose tissue显示文摘 | MCCANN D DESAI M | 2003 | J Clin Invest2003，112，12： | 1 |
| 4 | Overpressures from non-detonating baffle-accelerated turbulent flames in tubes显示文摘 | DUNN-RANKIN D and MCCANN M A | 2000 | Combustion and Flame2000，120，： | 1 |
| 5 | Stimulatory and inhibitory effects of purified hypothalamic extracts on growth hormone release from rat pituitary in vitro显示文摘 | Krulich L Dhariwal A P McCann S M | 1968 | Endocrinology1968，83，4： | 1 |
| 6 | Complications of defini- tive open reduction and internal fixation of Pilon fractures of the distal tibia显示文摘 | McCann PA Jackson M Mitchell ST | 2011 | Int Orthop2011，35，： | 1 |
| 7 | A pectate lyase from Zinnia elegans is auxin inducible显示文摘 | Domingo C Roberts K Stacey N J Connerton I RuoAz-TeraAn F McCann M C | 1998 | Plant J1998，13，： | 1 |
| 8 | Interventions for preventing infectious complications in haemodialysis patients with central venous catheters 显示文摘 | McCann M Moore ZE | 2010 | Cochrane Database Syst Rev2010，20，1： | 1 |
| 9 | Neural network analyses of infrared spectra for classifying cell wall architectures 显示文摘 | Mccann M C Defernez M Urbanowicz B R | 2007 | Plant Physiology2007，143，3： | 1 |
| 10 | The relationship between estimated glomerular filtration rate and thyroid function: an observational study显示文摘 | Woodward A McCann S Al-Jubouri M | 2008 | Ann Clin Biochem2008，45，5： | 1 |
| 11 | Prognostic significance of c-erbB-2 and estrogen receptor status in human breast cancer 显示文摘 | McCann AH Dervan PA O'Regan M | 1991 | Cancer Res1991，51，12： | 1 |
| 12 | Obesity is associated with macrophage accumulation in adipose tissue 显示文摘 | WEISBERG S P MCCANN D DESAI M | 2003 | J Clin Invest2003，112，12： | 1 |
| 13 | Obesity is associated with macrophage accumulation in adipose tissue 显示文摘 | Weisberg SP McCann D Desai M | 2003 | J Clin Invest2003，112，12： | 1 |
| 14 | Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of TNF-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis 显示文摘 | McCann F E Palfreeman A C Andrews M | 2010 | Arthritis Res Ther2010，12，3： | 1 |
| 15 | Obesity is associated with macrophage accumulation in adipose tissue 显示文摘 | Weisberg SP McCann D Desai M | 2003 | Journal of Clinical Investigation2003，112，12： | 1 |
| 16 | Distinguishing between di- rectional guidance and motility regulation in neuronal migration显示文摘 | Ward M Mccann C Dewulf M | 2003 | J Neurosci2003，，12： | 1 |
| 17 | Role of leptin in hypothalamic-pituitary function 显示文摘 | Kimura M Walczewska A Karanth S McCann SM | 1997 | Proc Natl Acad Sci USA1997，94，3： | 1 |
| 18 | The management of preoperative anxiety in children: an update显示文摘 | McCANN M E KAIN I N | 2001 | Anesth Analg2001，93，： | 1 |
| 19 | A Review of Thin-film Crystalline Silicon for Solar Cell Applications Part 2∶Foreign Substrate显示文摘 | McCann M J Catchpole K R Weber K J | 2001 | Solar Energy Materials and Solar Cells2001，，68： | 1 |
| 20 | Complications of definitive open reduction and internal fixation of pilon fractures of the distal tibia显示文摘 | McCann PA Jackson M Mitchell ST | 2011 | Int Orthop2011，35，3： | 1 |
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