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| 1 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 2 | Risk factors and outcomes of delayed graft function in renal transplant recipients receiving a steroid sparing immunosuppression protocol显示文摘AIM To analyse the risk factors and outcomes of delayed graft function(DGF) in patients receiving a steroid sparing protocol. METHODS Four hundred and twenty-seven recipients of deceased donor kidney transplants were studied of which 135(31.6%) experienced DGF. All patients received monoclonal antibody induction with a tacrolimus based, steroid sparing immunosuppression protocol.RESULTS Five year patient survival was 87.2% and 94.9% in the DGF and primary graft function(PGF) group respectively, P = 0.047. Allograft survival was 77.9% and 90.2% in the DGF and PGF group respectively, P < 0.001. Overall rejection free survival was no different between the DGF and PGF groups with a 1 and 5 year rejection free survival in the DGF group of 77.7% and 67.8% compared with 81.3% and 75.3% in the PGF group, P = 0.19. Patients with DGF who received IL2 receptor antibody induction were at significantly higher risk of rejection in the early post-transplant period than the group with DGF who received alemtuzumab induction. On multivariate analysis, risk factors for DGF were male recipients, recipients of black ethnicity, circulatory death donation, preformed DSA, increasing cold ischaemic time, older donor age and dialysis vintage.CONCLUSION Alemtuzumab induction may be of benefit in preventing early rejection episodes associated with DGF. Prospective trials are required to determine optimal immunotherapy protocols for patients at high risk of DGF. | Michelle Willicombe Anna Rizzello Dawn Goodall Vassilios Papalois Adam G Mc Lean David Taube | 2017 | World Journal of Transplantation2017，7，1： | 4 |
| 3 | 利钠肽受体2的缺乏促进小鼠二叶主动脉瓣、主动脉瓣疾病、左心室功能不全以及升主动脉扩张显示文摘主动脉瓣疾病是无有效药物治疗的细胞介导的病变过程。C型利钠肽(C-type natriuretic peptide,CNP)抑制瓣膜间质细胞(valve interstitial cells,VIC)的肌纤维形成和成骨过程,并且在出现主动脉瓣狭窄时水平下调。然而,CNP信号是否调节体内主动脉瓣的健康状态尚不清楚。该研究旨在确定小鼠CNP信号通路的缺失是否导致主动脉瓣疾病加速发展。 | 刘青 叶鹏 Blaser MC Wei K Adams RL Zhou YQ Caruso LL Mirzaei Z Lam A Tam RK Zhang H Heximer SP Henkelman M Simmons CA | 2018 | 中华高血压杂志2018，26，1： | 3 |
| 4 | Cure of Fisher rats bearing :adioresistant F98 glioma treated with cis-platinum and irradiated with monochromatic synchrotron X-rays显示文摘 | Biston MC Joubert A Adam JF | 2004 | Cancer Res2004，64，7： | 1 |
| 5 | Coronal cuff:A prob-blem for buccal mucosal graft显示文摘 | Adams MC Miller DA | 1999 | J Urol1999，162，： | 1 |
| 6 | Shoot dieback during prolonged drought in Ceanothus (Rhamnaceae) chaparral of California: a possible case of hydraulic failure 显示文摘 | Davis SD Ewers FW Sperry JS Portwood KA Crocker MC Adams GC | 2002 | Am JBot2002，89，： | 1 |
| 7 | Adult-Onset Presenta- tion of Glutaric Acidemia Type II With Myopathy 显示文摘 | Mareska MC Adams KK Muenzer J | 2003 | J Clin Neuro- muscul Dis2003，4，： | 1 |
| 8 | A 63 -year old woman with weight loss and muhiple Lung nod- ules 显示文摘 | Erasmus JJ Mc Adams HP Carraway MS | 1997 | Chest1997，111，1： | 1 |
| 9 | Proof of concept processes in UK university technology transfer:an absorptive capacity perspective显示文摘 | Mc Adam R Mc Adam M Brown V | 2009 | R&D Management2009，39，2： | 1 |
| 10 | Castleman disease of the thorax:radiologic features with clinical and histopathologic correlation显示文摘 | Mc Adams HP Rosado-de-Christenson M Fishback NF | 1998 | Radiology1998，209，： | 1 |
| 11 | Stress distributions inside intervenebral discs:the effects of age and degeneration显示文摘 | Adams MA Mc Nally DS Dolan P | 1996 | J Bone Joint Surg Br1996，78，3： | 1 |
| 12 | Total wrist arthroplasty显示文摘 | Anderson MC Adams BD | 2005 | Hand Clin2005，4，： | 1 |
| 13 | A comparison of public and private sector pemeptions and use of knowledge management显示文摘 | Rodney Mc Adam Renee Reid | 2000 | Journal of European Industrial Training2000，24，6： | 1 |
| 14 | 显示文摘 | ADAM Mc D P HILL A S BEASLEY H L | 1992 | Agric Food Chem1992，40，： | 1 |
| 15 | Factors affecting anastomotic complications following anterior resection in rectal cancer显示文摘 | Lyall A Mc Adam TK Townend J | 2007 | Colorectal Dis2007，9，9： | 1 |
| 16 | Feminizing genitoplasty: state of the art 显示文摘 | Rink RC Adams MC | 1998 | World J Urol1998，16，： | 1 |
| 17 | Personality profiles among normal aged in din: duals as measure by the NEO--PI--R显示文摘 | Roepkes Mc Adams L A | 2001 | Aging Mental Healthy2001，5，： | 1 |
| 18 | Feminizing genitoplasty:state of the art显示文摘 | Rink RC Adams MC | 1998 | World J Urol1998，16，33： | 1 |
| 19 | Thrombin interaction with platelet membrane glycoprotein Ib alpha 显示文摘 | Adam F Bouton MC Huisse MG | 2003 | Trends Mol Med2003，9，： | 1 |
| 20 | Orchiopexy for intra-abdominal testes:factors predicting success显示文摘 | Stec AA Tanaka ST Adams MC | 2009 | J Urol2009，182，4： | 1 |
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