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| 1 | Measurement of circulating levels of VEGF-A,-C,and -D and their receptors,VEGFR-1 and -2 in gastric adenocarcinoma显示文摘AIM: To analyze the serum levels and prognostic significance of vascular endothelial growth factor (VEGF) -A,-C,and -D,and their receptors,VEGFR-1 and -2 in gastric adenocarcinomas. METHODS: The serum levels of VEGF family members were measured in 76 control subjects and 76 patients with gastric adenocarcinoma using an enzyme-linked immunosorbent assay (ELISA). These measurements were correlated with clinco-pathological features and survival rates. RESULTS: The serum levels of VEGF-A and its receptor,VEGFR-1,were signifi cantly higher in patients with gastric cancer than in healthy donors (t = 2.3,P = 0.02 and t = 4.2,P < 0.0001,respectively). In contrast,the serum levels of VEGF-D were signif icantly higher in control subjects than in patients (t = 2.9,P = 0.004). There was no significant difference in serum levels of VEGF-C and VEGFR-2 between patients and controls. VEGF-C was associated with advanced tumor stage and presence of metastasis. VEGFR-1 was associated with metastasis,advanced overall stage,tumor differentiation and survival. VEGFR-2 levels were associated with poor tumor differentiation. There was no significant prognostic value for any of the VEGF family members or their receptors except for VEGFR-1 where high levels were associated with a poor overall survival. CONCLUSION: Serum VEGF levels vary significantly in the same cohort of patients with variable clinico-pathological features and prognostic values. The simultaneous measurement of VEGF receptors levels in sera may overcome the limitations of a single biomarker assay. | Mansour S Al-Moundhri A Al-Shukaili M Al-Nabhani B Al-Bahrani IA Burney A Rizivi SS Ganguly | 2008 | World Journal of Gastroenterology2008，14，24： | 32 |
| 2 | 25-羟维生素D和甲状旁腺激素与高血压的相关性显示文摘有研究证实,维生素D缺乏和甲状旁腺激素(PTH)过高与高血压的发生密切相关。维生素D缺乏不仅可以影响肾素血管紧张素系统及PTH水平,而且可以直接参与血管炎性反应,影响高血压的发生发展。PTH可以通过促进血管炎性反应及血管钙化等参与高血压的进展。目前还没有前瞻性研究同时评估维生素D和PTH水平与高血压发病的关系。该研究分析多民族动脉粥样硬化研究的前瞻性数据,发现低水平25羟维生素D[25(OH)D]和高水平PTH与高血压发病相关,特别是在肥胖人群中。但在校正混杂因素后,25(OH)D水平与高血压发病的相关性无统计学意义,而PTH水平与高血压发病仍然相关。鉴于维生素D缺乏和PTH过量在人群中是普遍现象,该研究对于更好地了解高血压发病机制,在人群中开展高血压预防工作有重要意义。 | van Ballegooijen AJ Kestenbaum B Sachs MC de Boer IH Siscovick DS Hoofnagle AN Ix JH Visser M Brouwer IA 练桂丽 叶鹏 | 2014 | 中华高血压杂志2014，22，6： | 10 |
| 3 | Long-chain n-3 polyunsaturated fatty acids:new insights into mechanisms relating to inflammation and coronary heart disease显示文摘 | de Roos B Mavrommatis Y Brouwer IA | 2009 | Br J Pharmacol2009，，2： | 1 |
| 4 | Patient-controlled sedation forelderly patients: safety and patient attitude toward control 显示文摘 | Herrick IA Gelb AW Nichols B | 2008 | Can J Anaesth2008，43，： | 1 |
| 5 | Ellagic acid normalizes mitochondrial outer membrane permeabilization and attenuates inflammation-mediated cell proliferation in experimental liver cancer显示文摘 | Srigopalram S Jayraaj IA Kaleeswaran B | 2014 | Appl Biochem Biotechnol2014，173，8： | 1 |
| 6 | Immune cell populations decrease during eraniotomy under general anesthesia 显示文摘 | Liu S Wang B IA S | 2011 | Anesth Arialg2011，113，3： | 1 |
| 7 | A simple method for accurate quantification of complement receptor 1 on erythrocytes preserved by fixing or freezing显示文摘 | Cockburn IA Donvito B Cohen JH | 2002 | J Immunol Methods2002，271，： | 1 |
| 8 | Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin显示文摘 | Li B Yuan M Kim IA | 2004 | Oncogene2004，23，26： | 1 |
| 9 | Rock mass grouting in the L?ren tunnel:case study with the main focus on the groutability and feasibility of drill parameter interpretation显示文摘 | H?IA H NILSEN B | 2014 | Rock Mechanics and Rock Engineering2014，47，3： | 1 |
| 10 | Decidualization of thehuman endometrium: mechanisms, functions, and clinicalperspectives 显示文摘 | Gellersen B Brosens IA Brosens JJ | 2007 | Semin Reprod Med2007，25，： | 1 |
| 11 | Contrast-induced coronary no-flow phenomenon: during diagnostic coronary angiography显示文摘 | Bolad IA Khan B Ghumman W | 2011 | Tex Heart Inst J2011，38，5： | 1 |
| 12 | MicroRNA -214 contributes to melanoma tumour progression through suppression of TFAP2C显示文摘 | Penna E Orso F Cimino D Tenag|ia E Lembo A Quaglino E Poliseno L Haimovic A Osella-Abate S De Pitta C Pinatel E Stadler M B Provero P Bemengo M G Osman I Taverna D | 2011 | EMBO Journal2011，30，10： | 1 |
| 13 | Nongastric mucosa-associated lymphoid tissue lymphomas显示文摘 | Thieblemont C de ia Fouchardiere A Coiffier B | 2003 | Clin Lymphoma2003，3，4： | 1 |
| 14 | Characterisation of the 3D Waviness and Roughness Motifs 显示文摘 | MEZGHAN IA S b ZAHOUAN IA H B | 2004 | Wear2004，257，： | 1 |
| 15 | A giant virus in amoeba显示文摘 | IA SCOLA B | 2003 | Science2003，299，： | 1 |
| 16 | A ssessm ent ofnovel probiotic Lactobaillus casei strains for the production of functional dairy foods显示文摘 | M IN ELLI E B BEN IN IA M A RZ0 TT0 M etal | 2004 | Int Dairy J2004，14，8： | 1 |
| 17 | Targeting sphingosine kinase1 attenuates bleomycin-induced pulmonary fibrosis显示文摘 | Huang LS Berdyshev E Mathew B Fu P Gorshkova IA He D | 2013 | FASEB J2013，27，4： | 1 |
| 18 | Acute and chronic effects of transmyocardial laser revascularization in the nonischemic pig myocardium by using three laser systems显示文摘 | Genyk IA Frenz M Ott B | 2000 | Lasers Surg Med2000，27，5： | 1 |
| 19 | Activated cell cycle checkpoints in epirubicin-treated breast cancer cells studied by BrdUrd-flow cytometry 显示文摘 | Hedenfalk IA Baldetorp B Borg A | 1997 | Cytometry1997，29，4： | 1 |
| 20 | Ewing's sarcoma and the development of secondary malignancies 显示文摘 | Fuchs B Valenzuela RG Petersen IA | 2003 | Clin Orthop Relat Res2003，，415： | 1 |
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