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| 1 | 中国肺癌死亡趋势分析及发病、死亡的估计与预测显示文摘背景与目的利用我国现有相对较完善的肺癌发病死亡资料,描述中国肺癌死亡趋势,并估计和预测2000年及2005年的肺癌发病与死亡状况,以期对我国肺癌临床、基础研究及防治策略制定提供依据及参考.方法利用Joinpoint模型对卫生部上报WHO的中国1987~1999年肺癌死亡数据进行趋势分析,结合我国1990~1992年第二次全死因调查结果及我国入选<五大洲癌症发病率>第八卷中肿瘤登记处的肺癌发病死亡数据,采用对数线性模型(基于Poisson分布),估计并预测2000年及2005年中国肺癌的发病、死亡状况.结果我国肺癌年龄调整死亡率总体呈上升趋势,尤以农村明显(男性年均上升2.7%,女性上升3.6%,均有统计学意义)且各年龄段(15岁以上)均呈不同程度上升趋势.自2000年至2005年,我国肺癌的死亡人数将增加10.1万(自2000年的32.7万增至2005年的42.8万),发病人数将增加11.6万(自2000年的38.1万增至2005年的49.7万).结论由于肺癌危险因素变化及人口增长、老龄化的双重作用,肺癌已成为中国近年来最常见、增幅最大的恶性肿瘤之一,其预防与控制将成为未来中国肿瘤控制计划制定和实施的重点之一,而控制烟草无疑成为其关键. | 杨玲 李连弟 陈育德 Donald Maxwell Parkin | 2005 | 中国肺癌杂志2005，8，4： | 167 |
| 2 | 时间域瞬变电磁法中心方式全程视电阻率的数值计算显示文摘给出了一种时间域瞬变电磁法视电阻率的数值计算方法 ,利用该方法可以容易地求出中心方式的全程视电阻率 .根据中心方式磁场垂直分量时间变化率 Bz T的核函数Y′(Z)的表现特征 ,以参数Z把整个瞬变过程分为早期阶段 (Z >1.6 )、早期到晚期的转折点 (Z =1.6 )和晚期阶段 (Z <1.6 ) .首先分别得到早期视电阻率和晚期视电阻率的精确值 ,然后通过转折点构成一条完整的全程视电阻率曲线 .虽然磁场垂直分量Bz 的核函数Y(Z)是参数Z的单值函数 ,但同样存在一个从早期到晚期的转折点Z =1.6 ,转换点两边仍然可以得到一条早期曲线和一条晚期曲线 .在数值计算中 ,当迭代步长ΔZ <0 .0 0 5Z时 ,视电阻率的相对误差小于 0 .5 % .理论模型和实际数据计算表明 ,与早期和晚期近似值比较 ,全程视电阻率具有更高的精度和分辨率 . | 白登海 Maxwell A Meju 卢健 王立凤 何兆海 | 2003 | 地球物理学报2003，46，5： | 157 |
| 3 | 瞬变电磁法中两种关断电流对响应函数的影响及其应对策略显示文摘关断时间是影响瞬变电磁资料处理和解释质量的一个重要因素 ,也是衡量TEM仪器性能的一个关键参数。提出了一种直接数值校正方案 ,并通过对线性和指数关断电流的校正描述了该方案的实施过程。根据文中提出的方案 ,只要仪器记录了一次场的衰减曲线 ,就可以进行较为精确的校正 ,并不必要假设线性衰减或指数衰减 ,这一结论无论是对TEM的仪器设计还是数据处理都具有重要意义。 | 白登海 Maxwell Meju | 2001 | 地震地质2001，23，2： | 59 |
| 4 | 东亚地区癌症负担和预防策略显示文摘目的:探讨东亚地区当前的癌症负担、危险因素、预防和控制策略。方法:应用全球癌症数据库和5大洲癌症发病资料,利用发病率、死亡率和患病率指标估计东亚地区的癌症负担,分析主要癌症的预防策略。结果:东亚地区癌症的年新发病例数为280万,死亡病例200多万,现患病例490万。最常见的5种癌症是胃癌、肺癌、肝癌、食管癌和结直肠癌,占东亚地区癌症年新发病例数的68%(分别占癌症年新发病例数的18.7%、16.9%、14.2%、9.4%和9.1%)。预计2050年的癌症新发病例数将达600万,死亡病例450万。结论:癌症是目前和今后东亚地区面临的严重公共卫生问题,必须贯彻以预防为主的方针。 | 蔡琳 GOLDSTEIN Binh Yang PARKIN Donald Maxwell 张作风 | 2008 | 肿瘤2008，28，5： | 36 |
| 5 | SJWD14121600000297显示文摘 | Jacques Ferlay Isabelle Soerjomataram Rajesh Dikshit Sultan Eser Colin Mathers Marise Rebelo Donald Maxwell Parkin David Forman Freddie Bray | 2015 | Int. J. Cancer2015，，5： | 31 |
| 6 | Gastroesophageal reflux disease: Important considerations for the older patients显示文摘Gastroesophageal reflux disease (GERD) is the most common upper gastrointestinal disorder seen in the elderly. The worldwide incidence of GERD is increasing as the incidence of Helicobacter pylori is decreasing. Although elderly patients with GERD have fewer symptoms, their disease is more often severe. They have more esophageal and extraesophageal complications that may be potentially life threatening. Esophageal complications include erosive esophagitis, esophageal stricture, Barrett's esophagus and adenocarcinoma of the esophagus. Extraesophageal complications include atypical chest pain that can simulate angina pectoris; ear, nose, and throat manifestations such as globus sensation, laryngitis, and dental problems; pulmonary problems such as chronic cough, asthma, and pulmonary aspiration. A more aggressive approach may be warranted in the elderly patient, because of the higher incidence of severe complications. Although the evaluation and management of GERD are generally the same in elderly patients as for all adults, there are specific issues of causation, evaluation and treatment that must be considered when dealing with the elderly. | Maxwell M Chait | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，12： | 22 |
| 7 | 基于家庭的TGFβ1基因-509C/T多态性与IgA肾病相关性研究显示文摘目的 :以家庭为基础 ,利用遗传不平衡原理研究转化生长因子β1(TGFβ1)基因 - 5 0 9C/T多态性与中国汉族人群IgA肾病的相关关系。方法 :用PCR -RFLP法和PCR产物直接测序法鉴定基因型 ,采用家庭为基础的传递不平衡检验 (TDT)、单体型相对风险 (HRR)分析的方法。进一步病例追踪随访。结果 :① 10 6个满足经典TDT分析的核心家庭中 ,杂合子父母传递给患病子代的等位基因频率不比预期值高 ,16 8个家庭的扩展TDT分析也验证了这一结果 (χ2 =0 5 5 8,P >0 0 5 ;χ2 =0 399,P >0 0 5 )。② 130个满足HRR分析的核心家庭中 ,HRR分析显示TGFβ1基因 - 5 0 9C/T多态性不使病人具有更高的发病风险 (Genotype -basedHRR χ2 =0 6 77,P >0 0 5 ,Haplotype -basedHRR χ2 =0 6 5 0 ,P >0 0 5 ,HRR =0 86 5 )。③ 2 96例IgA肾病病人的追踪随访发现 :肾功能恶化组CC基因型出现频率显著增高 [χ2 (CC/others) =10 4 0 2 ,P <0 0 1,OR =2 90 0 ]。结论 :中国汉族人群中 ,TGFβ1基因 - 5 0 9C/T多态性可能和肾病的病程进展相关。但和IgA肾病的易感性不相关。 | 薛超 李幼姬 李彩霞 杜勇 黄伟俊 夏运风 黎嘉能 Patrick H Maxwell 王一鸣 | 2005 | 中国病理生理杂志2005，21，3： | 18 |
| 8 | SJWD14121600000297显示文摘 | Jacques Ferlay Isabelle Soerjomataram Rajesh Dikshit Sultan Eser Colin Mathers Marise Rebelo Donald Maxwell Parkin David Forman Freddie Bray | 2015 | Cancer2015，，5： | 15 |
| 9 | TCRCα-560C/T多态性与IgA肾病临床病理的关联分析显示文摘目的: 探讨T细胞受体保守域Alpha链基因(TCRCα)- 560C/T多态性与我国汉族人群IgA肾病临床病理的相关关系.方法: PCR RFLP法和PCR产物直接测序法鉴定400例IgA肾病患者的基因型,按基因型分为TT(135人),TC(196人)和CC(69人)3组.与其临床病理资料进行关联分析,并追踪随访.结果: ①TCRCα560的TT基因型的患者其蛋白尿发生率显著降低(P<0. 05),而CT基因型的患者蛋白尿发生率则显著增高(P<0 01 ),CC基因型的患者发生蛋白尿的比例亦有增高趋势;②在IgA肾病病理中度病变组,CC基因型的分布频率相对于其他基因型有显著增高(P<0 .05 );③211例随访患者,TCRCα- 560C/T基因在肾功稳定组与进展组间,不论是基因型还是等位基因的分布频率均未见显著性差异(P>0 .05).结论: 中国汉族人群中,TCRCα基因-560C/T基因多态性可能和IgA肾病蛋白尿的发生及肾病病理有一定关联性,但可能与肾功能进展不相关. | 薛超 李幼姬 李彩霞 王一鸣 胡彬 陈路明 黎嘉能 Patrick H Maxwell | 2005 | 第四军医大学学报2005，26，10： | 11 |
| 10 | 中国汉族人群TCRCα基因-575A/G多态性与IgA肾病临床病理的相关分析显示文摘目的:探讨T细胞受体保守域α链基因(TCRCα)-575 A/G多态性与中国汉族人群IgA肾病临床病理的相关关系.方法:PCR-RFLP法和PCR产物直接测序法鉴定基因型,对IgA肾病患者的临床及病理资料进行相关分析,并对病例进行追踪随访.结果:①291例患者临床资料分析显示:在伴有肉眼血尿患者中AA基因型的出现频率显著性升高(P<0.05);在年龄、性别、血压、血尿、蛋白尿、血清IgA水平等临床指标中任何基因型的分布频率均无统计学意义(P>0.05).②294例患者病理资料分析显示:在IgA肾病Haas分级的Ⅱ+Ⅲ级的患者中,AA基因型其分布频率相对于其他基因型有显著增加(P<0.05).③219例IgA肾病患者,TCRCα基因-575 A/G不论是基因型还是等位基因,在肾功能稳定组与进展组相比较均未见显著性差异(P>0.05).结论:中国汉族人群中,TCRCα基因-575 A/G多态性可能和肉眼血尿的发生、系膜增生相关,但可能与肾功能进展不相关. | 薛超 李幼姬 李彩霞 杜勇 王一鸣 黄玮俊 夏运风 黎嘉能 Patrick H Maxwell | 2005 | 第四军医大学学报2005，26，22： | 10 |
| 11 | 摄入石墨烯量子点的家蚕可直接吐出力学性能增强的蚕丝(英文)显示文摘家蚕蚕丝具有细腻、光鲜以及优良的力学特性,因而在诸多领域中都有广泛应用.许多科学家对提高家蚕蚕丝力学性能的研究非常感兴趣.本工作中,我们通过血管注射的方式给家蚕幼虫注入了石墨烯量子点(GQDs),并且得到了力学性能增强的蚕丝. GQDs可通过淋巴循环进入到家蚕的丝腺器官并影响家蚕的纺丝过程.研究发现,当家蚕的GQDs摄入量为0.6μg/头时,家蚕蚕丝的断裂强度、断裂伸长率以及韧性模量可分别增强到原来的2.74, 1.33和3.62倍.广角X射线散射(WAXS)结果表明GQDs-蚕丝中的β-折叠纳米晶体的尺寸比起空白蚕丝有所降低,红外光谱结果表明GQDs限制了丝素蛋白中无规则卷曲或者α-螺旋结构向β-折叠结构的构象转变.β-折叠结构的尺寸及含量的变化可能是引起蚕丝力学性能增强的原因所在.我们还对GQDs的毒性以及单头家蚕摄入GQDs的安全限进行了评估,结果发现家蚕摄入GQDs的上限为30.0μg/头.使家蚕直接摄入GQDs获得力学性能增强的蚕丝的方法为生产高强度蚕丝提供了一种有潜力的途径. | 马琳 Maxwell Akologo Akurugu Vivian Andoh 刘海燕 宋江超 武国华 李龙 | 2019 | Science China Materials2019，62，2： | 8 |
| 12 | Comparison between endoscopic sphincterotomy vs endoscopic sphincterotomy associated with balloon dilation for removal of bile duct stones:A systematic review and meta-analysis based on randomized controlled trials显示文摘AIM To compare gallstones removal rate and incidence of bleeding, pancreatitis, use of mechanical lithotripsy, cholangitis and perforation between isolated sphincterotomy vs sphincterotomy associated with balloon dilation of papilla in choledocholithiasis through the meta-analysis of randomized clinical trials. METHODS We conducted a systematic review according to the PRISMA guidelines. Literature search was restricted to randomized controlled trials(RCTs) on Med Line, Cochrane Library, LILACS, and EMBASE database platforms in July 2017. The manual search included references of retrieved articles. We extracted data focusing on outcomes: The primary endpoint was the stones removal rate; Secondary endpoints were rates of pancreatitis, bleeding, use of mechanical lithotripsy(ML), perforation and cholangitis. RESULTS Eleven RCTs with 1824 patients were included. EST was associated with more post-endoscopic retrograde cholangiopancreatography(ERCP) bleeding [FE RD-0.02, CI(-0.03,-0.00), I2 = 33%, P = 0.05] and more need of mechanical lithotripsy in general [RE RD-0.16, CI(-0.25,-0.06), I2 = 90%, P = 0.002] and in subgroup analysis of stones greater than 15 mm [RE RD-0.20, CI(-0.38,-0.02), I2 = 82%, P = 0.003]. Incidence of pancreatitis [FE RD-0.01, CI(-0.03, 0.01), I2 = 0, P = 0.36], cholangitis [FE RD-0.00, CI(-0.01, 0.01), I2 =0, P = 0.97] and perforation [FE RD-0.01, CI(-0.01, 0.00), I2 = 0, P = 0.23] was similar between the groups as well as similar stone removal rates in general [FE RD-0.01, CI(-0.01, 0.04), I2 = 0, P = 0.23] and pooled analysis of stones greater than 15 mm [FE RD-0.02, CI(-0.02, 0.07), I2 = 11%, P = 0.31]. CONCLUSION Through meta-analysis of randomized clinical trials we found that isolated sphincterotomy was associated with more post-ERCP bleeding and more need for mechanical lithotripsy. However, there was no statistical difference in the stone removal rate between isolated sphincterotomy and sphincterotomy associated with balloon dilation in the approach to remove gallstones. | Cesar Capel de Clemente Junior Wanderley Marques Bernardo Tomazo Prince Franzini Gustavo Oliveira Luz Marcos Eduardo Lera dos Santos Jonah Maxwell Cohen Diogo Turiani Hourneaux de Moura Fábio Ramalho Tavares Marinho Martin Coronel Paulo Sakai Eduardo Guimaraes Hourneaux de Moura | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，8： | 8 |
| 13 | 氮自掺杂暴露(001)晶面TiO_2微米片的可见光光催化CO_2还原性能增强(英文)显示文摘化石能源的使用可产生大量CO2,带来严重的温室效应.光催化CO2还原生产太阳燃料技术既有望缓解温室效应,又可以将低能量密度的太阳能转化为高能量密度的化学能储存起来方便使用.高效光催化材料的开发是发展光催化技术的关键.迄今,在已开发的所有半导体光催化材料中,Ti O2仍是广泛研究的明星材料.在实际使用中,Ti O2的光催化效率仍受限于其极弱的可见光利用率和较高的电子-空穴复合几率.近年来,越来越多的研究表明Ti O2的结构与形貌特征极大地影响其光催化效率.尤其,Ti O2的外露晶面设计与晶面效应研究引起了广泛关注.由于具有较高表面能和较多表面不饱和键,起初大多数理论和实验研究认为锐钛矿Ti O2(001)晶面是光催化活性晶面.后来,越来越多研究表明并非锐钛矿Ti O2(001)晶面的暴露比例越高其光催化活性就越高.最近,我们发现锐钛矿Ti O2(001)晶面与(101)晶面在调控光催化CO2还原性能上具有良好的协同效应.密度泛函理论计算表明,锐钛矿Ti O2的(001)晶面与(101)晶面的能带结构有差异,(001)晶面的导带位置相对于(101)晶面而言较高,而(101)晶面的价带位置相对于(001)晶面而言较低.基于此我们提出,具有合适比例的锐钛矿Ti O2的(001)晶面与(101)晶面的交界处可以形成最佳的表面异质结或晶面异质结.表面异质结的形成导致光生电子倾向于向(101)扩散,光生空穴倾向于向(001)扩散,从而促进光生电子-空穴分离,降低光生电子-空穴复合几率.在此工作基础上,我们直接以氮化钛为原料,氢氟酸为添加剂,通过简单的水热反应一步合成了氮自掺杂的Ti O2微米片.利用X射线粉末衍射、扫描电镜、X射线光电子能谱、紫外-可见漫反射光谱、氮气吸附-脱附以及电化学阻抗谱等方法手段对所制备的光催化剂进行了基本结构与理化性质表征分析,并研究了其可见光光催化CO2还原性能.电镜照片结果表明,我们所制备的氮自掺杂锐钛矿Ti O2微米片的(001)晶面与(101)晶面比例分别为65%和35%.基于我们前期研究结果,Ti O2微米片的(001)晶面与(101)晶面可以形成表面异质结,具有良好的电荷分离效率,这也得到了电化学阻抗谱研究结果的证明.同时,由于N的原位掺杂,所制备的Ti O2微米片具有优异的可见光捕获能力.由于可见光利用效率增强与光生电子-空穴分离效率提高这两方面的综合作用,所制备的氮自掺杂Ti O2微米片具有非常好的可见光光催化CO2还原制甲醇性能,比商用P25及氮掺杂Ti O2纳米粒子等参考样品的可见光光催化性能更优异.研究表明,通过原位自掺杂方法与晶面设计方法相结合,可以同时改善Ti O2的可见光利用效率和光生电子-空穴分离效率,优化Ti O2的可见光光催化性能,这也为后续开发新型高效光催化材料提供了新思路. | Maxwell Selase Akple 刘敬祥 秦志扬 S.Wageh Ahmed.A.Al-Ghamdi 余家国 刘升卫 | 2015 | Chinese Journal of Catalysis2015，36，12： | 7 |
| 14 | Corporate governance and firm cash holdings in the US显示文摘 | Jarrad Harford Sattar A. Mansi William F. Maxwell | 2008 | Journal of Financial Economics2008，，3： | 7 |
| 15 | The R2R3-type MYB transcription factor MdMYB90-like is responsible for the enhanced skin color of an apple bud sport mutant显示文摘The anthocyanin content in apple skin determines its red coloration,as seen in a Fuji apple mutant.Comparative RNA-seq analysis was performed to determine differentially expressed genes at different fruit development stages between the wild-type and the skin color mutant.A novel R2R3-MYB transcription factor,MdMYB90-like,was uncovered as the key regulatory gene for enhanced coloration in the mutant.The expression of MdMYB90-like was 21.3 times higher in the mutant.MdMYB90-like regulates anthocyanin biosynthesis directly through the activation of anthocyanin biosynthesis genes and indirectly through the activation of other transcription factors that activate anthocyanin biosynthesis.MdMYB90-like bound to the promoters of both structural genes(MdCHS and MdUFGT)and other transcription factor genes(MdMYB1 and MdbHLH3)in the yeast one-hybrid system,electrophoretic mobility shift assay,and dual-luciferase assay.Transgenic analysis showed that MdMYB90-like was localized in the nucleus,and its overexpression induced the expression of other anthocyanin-related genes,including MdCHS,MdCHI,MdANS,MdUFGT,MdbHLH3,and MdMYB1.The mutant had reduced levels of DNA methylation in two regions(−1183 to−988 and−2018 to−1778)of the MdMYB90-like gene promoter,which might explain the enhanced expression of the gene and the increased anthocyanin content in the mutant apple skin. | Chao Sun Chunming Wang Wang Zhang Shuai Liu Weiyao Wang Xinyi Yu Tao Song Maxwell Yu Weichang Yu Shenchun Qu | 2021 | Horticulture Research2021，8，1： | 6 |
| 16 | 中国汉族人群TGFβ_1基因-509C/T多态性及其IgA肾病的病例对照研究显示文摘【目的】探讨转化生长因子β1(TGFβ1)基因鄄509C/T多态性与中国汉族人群IgA肾病的相关关系。【方法】PCR鄄RFLP鉴定基因型,采用病例鄄对照与临床病理资料分析的方法,并行病例追踪随访。【结果】①387例IgA肾病病人的3种基因型与203例正常人对照组相比,分布频率无统计学意义,P>0.05。②临床资料显示:年龄、性别、血压、血尿、蛋白尿、血清IgA水平等临床指标中任何基因型的分布频率无统计学意义,P>0.05。③病理资料显示:CC基因型在肾小球中重度系膜增生病人中有较高的出现频率,而TT基因型相应明显减少,P<0.01;CC基因型在肾小球硬化组的分布频率显著增加,P<0.05。④进一步的病例追踪随访显示:CC基因型和C等位基因的IgA肾病病人尿蛋白好转率明显低于其它基因型,P<0.05。【结论】中国汉族人群中,TGFβ1基因鄄509C/T多态性可能与较重的肾损害、肾小球硬化、尿蛋白转归相关;但和IgA肾病的遗传易感性不相关。 | 薛超 李幼姬 李彩霞 杜勇 黄玮俊 夏运风 黎嘉能 Patrick H Maxwell 王一鸣 | 2005 | 中山大学学报(医学科学版)2005，26，3： | 5 |
| 17 | Targeted Antimicrobial Therapy Against Streptococcus mutans Establishes Protective Non-cariogenic Oral Biofilms and Reduces Subsequent Infection显示文摘Aim Dental biofilms are complex communities composed largely of harmless bacteria. Certain pathogenic species including Streptococcus mutans (S. mutans) can become predominant when host factors such as dietary sucrose intake imbalance the biofilm ecology. Current approaches to control S. mutans infection are not pathogen-specific and eliminate the entire oral community along with any protective benefits provided. Here, we tested the hypothesis that removal of S. mutans from the oral community through targeted antimicrobial therapy achieves protection against subsequent S. mutans colonization. Methodology Controlled amounts of S. mutans were mixed with S. mutans-free saliva, grown into biofilms and visualized by antibody staining and cfu quantization. Two specifically-targeted antimicrobial peptides (STAMPs) against S. mutans were tested for their ability to reduce S. mutans biofilm incorporation upon treatment of the inocula. The resulting biofilms were also evaluated for their ability to resist subsequent exogenous S. mutans colonization. Results S. mutans colonization was considerably reduced (9 ± 0.4 fold reduction, P=0.01) when the surface was preoccupied with saliva-derived biofilms. Furthermore, treatment with S. mutans-specific STAMPs yielded S. mutans-deficient biofilms with significant protection against further S. mutans colonization (5 minutes treatment: 38 ± 13 fold reduction P=0.01; 16 hours treatment: 96 ± 28 fold reduction P=0.07). Conclusion S. mutans infection is reduced by the pre- sence of existing biofilms. Thus maintaining a healthy or 'normal' biofilm through targeted antimicrobial therapy (such as the STAMPs) could represent an effective strategy for the treatment and prevention of S. mutans colonization in the oral cavity and caries progression. | Li-na Li Li-hong Guo Renate Lux Randal Eckert Daniel Yarbrough Jian He Maxwell Anderson Wen-yuan Shi | 2010 | International Journal of Oral Science2010，2，2： | 5 |
| 18 | STEP-POOL MORPHOLOGY IN HIGH-GRADIENT STREAMS显示文摘The focus of this study is to examine bed stability and morphology in high-gradient gravel-bed streams, and thus to improve understanding of the various parameters governing the sediment flow characteristics in mountain streams. Ultimately, this knowledge can be used to design pseudo-natural channels, as in the stream simulation method of culvert design; with this in mind, prototype conditions are evaluated in a flume with slopes ranging from 3% to 7%, and particle relative submergence varying from 0.5 to 2.5 for three bed size distributions. These experiments are designed to satisfy the conditions of dynamic similarity for flow and sediment, and they are preferred over field measurements since they allow a high degree of control over testing conditions. It is found that step-pool bedforms are the most ubiquitous features along the gravel bed. A new formula is developed that correlates step height with the gravel-bed size distribution, relative submergence of the particles, and the Froude number. The step spacing is found to be related to step height and streambed longitudinal slope. Flow resistance is also examined, and a formula is developed which accounts for the resistance due to the bedforms (form resistance), as well as the individual sediment particles (grain resistance). | A.R. MAXWELL and A.N. PAPANICOLAOU Research Assistant, Dept. of Civil and Envir. Engrg., Washington State University, Pullman, WA 99164-2910, Professor, Dept. of Civil and Envir. Engrg., Washington State University, Pullman, WA 99164-2910, | 2001 | International Journal of Sediment Research2001，16，3： | 5 |
| 19 | Von Hippel-Lindau tumor suppressor pathways&corresponding therapeutics in kidney cancer显示文摘The identification and application of the Von Hippel-Lindau(VHL)gene is a seminal breakthrough in kidney cancer research.VHL and its protein p VHL are the root cause of most kidney cancers,and the cascading pathway below them is crucial for understanding hypoxia,in addition to the aforementioned tumorigenesis routes and treatments.We reviewed the history and functions of VHL/pVHL and Hypoxia-inducible factor(HIF),their well-known activities under low-oxygen environments as an E3 ubiquitin ligase and as a transcription factor,respectively,as well as their non-canonical functions revealed recently.Additionally,we discussed how their dysregulation promotes tumorigenesis:beginning with chromosome 3 p-arm(3p)loss/epigenetic methylation,followed by two-allele knockout,before the loss of complimentary tumor suppressor genes leads cells down predictable oncological paths.These different pathways can ultimately determine the grade,outcome,and severity of the deadliest genitourinary cancer.We finished by investigating current and proposed schemes to therapeutically treat clear cell renal cell carcinoma(cc RCC)by manipulating the hypoxic pathway utilizing Vascular Endothelial Growth Factor(VEGF)inhibitors,mammalian target of rapamycin complex 1(mTORC1)inhibitors,small molecule HIF inhibitors,immune checkpoint blockade therapy,and synthetic lethality. | Maxwell Shulman Rachel Shi Qing Zhang | 2021 | Journal of Genetics and Genomics2021，48，7： | 4 |
| 20 | Three-dimensional distinct element modeling of fault reactivation and induced seismicity due to hydraulic fracturing injection and backflow显示文摘This paper presents a three-dimensional fully hydro-mechanical coupled distinct element study on fault reactivation and induced seismicity due to hydraulic fracturing injection and subsequent backflow process,based on the geological data in Horn River Basin,Northeast British Columbia,Canada.The modeling results indicate that the maximum magnitude of seismic events appears at the fracturing stage.The increment of fluid volume in the fault determines the cumulative moment and maximum fault slippage,both of which are essentially proportional to the fluid volume.After backflow starts,the fluid near the joint intersection keeps flowing into the critically stressed fault,rather than backflows to the wellbore.Although fault slippage is affected by the changes of both pore pressure and ambient rock stress,their contributions are different at fracturing and backflow stages.At fracturing stage,pore pressure change shows a dominant effect on induced fault slippage.While at backflow stage,because the fault plane is under a critical stress state,any minor disturbance would trigger a fault slippage.The energy analysis indicates that aseismic deformation takes up a majority of the total deformation energy during hydraulic fracturing.A common regularity is found in both fracturing-and backflow-induced seismicity that the cumulative moment and maximum fault slippage are nearly proportional to the injected fluid volume.This study shows some novel insights into interpreting fracturing-and backflowinduced seismicity,and provides useful information for controlling and mitigating seismic hazards due to hydraulic fracturing. | Zirui Yin Hongwei Huang Fengshou Zhang Lianyang Zhang Shawn Maxwell | 2020 | Journal of Rock Mechanics and Geotechnical Engineering2020，12，4： | 4 |
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