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| 1 | Gastric intestinal metaplasia development in African American predominant United States population显示文摘BACKGROUND Gastric cancer significantly contributes to cancer mortality globally.Gastric intestinal metaplasia(GIM)is a stage in the Correa cascade and a premalignant lesion of gastric cancer.The natural history of GIM formation and progression over time is not fully understood.Currently,there are no clear guidelines on GIM surveillance or management in the United States.AIM To investigate factors associated with GIM development over time in African American-predominant study population.METHODS This is a retrospective longitudinal study in a single tertiary hospital in Washington DC.We retrieved upper esophagogastroduodenoscopies(EGDs)with gastric biopsies from the pathology department database from January 2015 to December 2020.Patients included in the study had undergone two or more EGDswith gastric biopsy.Patients with no GIM at baseline were followed up until they developed GIM or until the last available EGD.Exclusion criteria consisted of patients age<18,pregnancy,previous diagnosis of gastric cancer,and missing data including pathology results or endoscopy reports.The study population was divided into two groups based on GIM status.Univariate and multivariate Cox regression was used to estimate the hazard induced by patient demographics,EGD findings,and Helicobacter pylori(H.pylori)status on the GIM status.RESULTS Of 2375 patients who had at least 1 EGD with gastric biopsy,579 patients were included in the study.138 patients developed GIM during the study follow-up period of 1087 d on average,compared to 857 d in patients without GIM(P=0.247).The average age of GIM group was 64 years compared to 56 years in the non-GIM group(P<0.001).In the GIM group,adding one year to the age increases the risk for GIM formation by 4%(P<0.001).Over time,African Americans,Hispanic,and other ethnicities/races had an increased risk of GIM compared to Caucasians with a hazard ratio(HR)of 2.12(1.16,3.87),2.79(1.09,7.13),and 3.19(1.5,6.76)respectively.No gender difference was observed between the study populations.Gastritis was associated with an increased risk for GIM development with an HR of 1.62(1.07,2.44).On the other hand,H.pylori infection did not increase the risk for GIM.CONCLUSION An increase in age and non-Caucasian race/ethnicity are associated with an increased risk of GIM formation.The effect of H.pylori on GIM is limited in low prevalence areas. | Akram I Ahmad Arielle Lee Claire Caplan Colin Wikholm Ioannis Pothoulakis Zaynab Almothafer NishthaRaval Samantha Marshall Ankit Mishra Nicole Hodgins In Guk Kang Raymond K Chang Zachary Dailey Arvin Daneshmand Anjani Kapadia Jae Hak Oh Brittney Rodriguez Abhinav Sehgal Matthew Sweeney Christopher B Swisher Daniel F Childers Corinne O'Connor Lynette M Sequeira Won Cho | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，10： | 1 |
| 2 | Ethylene trimerisation and tetramerisation catalysts with polar-substituted diphosphinoamine ligands 显示文摘 | MATTHEW I O KEVIN B ANNETTE B | 2005 | Chem Commun2005，，5： | 1 |
| 3 | Ef ect of chromium propi-onate and metabolizable energy on growth,carcass traits,and pork quality of growing-finishing pigs显示文摘 | Matthews J O Higbie A D Southern L I | | 0，，： | 1 |
| 4 | Aerobic degradation of di- and trichlorobenzenes by two bacteria isolated from polluted tropical soils 显示文摘 | Sunday A A Flynn W P Matthew O I | 2007 | Chemosphere2007，6，10： | 1 |
| 5 | New macrocyclic ligands synthetic,crystallographic and computational studies of a new N2O6-heteroatom cage显示文摘 | Atkinson I M Limdoy L F Matthews O A | 1994 | Ausst J Chem1994，47，6： | 1 |
| 6 | Self-service technologies: Understanding customer satisfaction with technology-based service encounters显示文摘 | Matthew L M Amy L O Robert I | 2000 | Journal of Marketing2000，64，3： | 1 |
| 7 | Determinants of pollinator activity and flower preference in the early spring blooming Crocus vernus显示文摘 | Totland O Matthews I | 1998 | Acta Oeeologica1998，19，2： | 1 |
| 8 | Pig musclefibre characteristics as a source of variation in eating quality显示文摘 | Mahin C A Warkup C C Matthews K R et o!I | 1997 | Meat Science1997，47，34： | 1 |
| 9 | Ethylene trimerisation and tetramerization catalysts with polar-substituted diphos-phinoamine ligands显示文摘 | Matthew I O Kevin B Annette B | 2005 | Chem Commun2005，，5： | 1 |
| 10 | An expensive,accurate method for measuring leaf area and defoliation through digital image analysis显示文摘 | MATTHEW E O DOUGLAS A L RUFUS I | 2002 | Field and Forage Crops2002，95，6： | 1 |
| 11 | 日粮强酸阴离子对绵羊酸碱平衡调节的影响显示文摘从食物吸收入血的强酸、强碱离子,直接影响细胞外液酸碱比率。试验目标为:通过添加经盐酸处理的芸苔降低日粮阴-阳离子差(DCAD),建立和完善绵羊抵抗日粮酸应激模式。盐酸处理的芸苔,是一种阴离子饲料添加物。试验采用完全随机区组设计。10只平均体重为(54.3±6.7)kg的小尾寒羊,饲喂对照添加物或阴离子添加物(AS)。 | Las J E Odongo N E Lindinger M I AIZahal O Shoveller A K Matthews J C McBride B W | 2007 | 饲料博览(技术版)2007，，10： | 0 |
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