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| 1 | 血流介导的血管舒张,硝酸甘油诱导的血管舒张,基线肱动脉直径,充血剪切应力与心血管病危险因素之间的相关性显示文摘血流介导的血管舒张功能(flow-mediated vasodilation,FMD)已被用于评估内皮功能。充血性剪切应力(hyperemic shear stress,HSS,一种FMD的刺激因素)、硝酸甘油诱导的血管舒张(nitroglycerine-induced vasodilation,NID,非内皮依赖性血管舒张指数)以及基线肱动脉直径(brachial artery diameter,BAD)也参与血管舒张反应。 | 刘青 叶鹏 Maruhashi T Iwamoto Y Kajikawa M Oda N Kishimoto S Matsui S Hashimoto H Aibara Y Yusoff FM Hidaka T Kihara Y Chayama K Noma K Nakashima A Goto C Hida E Higashi Y | 2018 | 中华高血压杂志2018，26，1： | 5 |
| 2 | Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer显示文摘AIM To investigate the anticancer mechanisms of the monoterpenoid alcohol linalool in human colon cancer cells.METHODS The cytotoxic effect of linalool on the human colon cancer cell lines and a human fibroblast cell line was examined using the WST-8 assay. The apoptosisinducing effect of linalool was measured using the terminal deoxynucleotidyl transferase d UTP nickend labeling assay and flow cytometry with Annexin V. Oxidative stress was investigated by staining for diphenyl-1-pyrenylphosphine, which is a cellular lipid peroxidation marker, and electron spin resonance spectroscopy. Sixteen SCID mice xenografted with human cancer cells were randomized into 3 groups for in vivo analysis: control and low-dose and high-dose linalool groups. The control group was administered tap water orally every 3 d. The linalool treatment groups were administered 100 or 200 μg/kg linalool solution orally for the same period. All mice were sacrificed under anesthesia 21 d after tumor inoculation, and tumors and organs were collected for immunohistochemistry using an anti-4-hydroxynonenal antibody. Tumor weights were measured and compared between groups. RESULTS Linalool induced apoptosis of cancer cells in vitro, following the cancer-specific induction of oxidative stress, which was measured based on spontaneous hydroxyl radical production and delayed lipid peroxidation. Mice in the high-dose linalool group exhibited a 55% reduction in mean xenograft tumor weight compared with mice in the control group(P < 0.05). In addition, tumor-specific lipid peroxidation was observed in the in vivo model.CONCLUSION Linalool exhibited an anticancer effect via cancerspecific oxidative stress, and this agent has potential for application in colon cancer therapy. | Kenichi Iwasaki Yun-Wen Zheng Soichiro Murata Hiromu Ito Ken Nakayama Tomohiro Kurokawa Naoki Sano Takeshi Nowatari Myra O Villareal Yumiko N Nagano Hiroko Isoda Hirofumi Matsui Nobuhiro Ohkohchi | 2016 | World Journal of Gastroenterology2016，22，44： | 5 |
| 3 | Brushless DC motors withou t position and speed sensor 显示文摘 | Matsui N Shigyo M | 1992 | IEEE Transactions on Industry Applications1992，28，1： | 1 |
| 4 | Heterogeneity of the pore and solid volume of soil: distinguishing a fraetal space from its nonfractal complement 显示文摘 | CRAWFORD J W MATSUI N | 1996 | Geoderma1996，73，： | 1 |
| 5 | Co-hquefaction of MicroAlgae with Coal Using Coal Liquefaction Catalysts显示文摘 | IKENAGA N UEDA C MATSUI T | | 0，，02： | 1 |
| 6 | Phylogenetic analysis of the gut bacterial microflora of the fungus-growing termite Odontomesformosanus显示文摘 | Shinzato N Muramatsu M Matsui T | 2007 | Biosci Biotechnol Biochem2007，71，4： | 1 |
| 7 | An ethanol-extract of Ampelopsis brevipedunculata (vitacease) berries de creases ferrous ironstimulated bepatocyte injury in Culture 显示文摘 | Yabe N Tanaka K Matsui H | 1998 | Journal of Ethnopharmacology1998，59，3： | 1 |
| 8 | Cytological study of grade 3 endometrioid adenocarcinoma of endometrial ori- gin:cytoarchiteeture and features of cell clusters assessed with endometrial brushing cytology-focusing on a compari- son with endometrioid adenoearcinoma Grade 1,2 显示文摘 | Matsui N Kajiwara H Morishita A | 2015 | To- kai J Exp Clin Med2015，40，2： | 1 |
| 9 | Heat shock suppresses membrane type 1-matrix metalloprteinase production and progelatinase A activation in human fibrosarcoma HT- 1080 cells and thereby inhibits cellular invasion 显示文摘 | Sato T Sawaji Y Matsui N | 1999 | Biochem Biophys Res Commun1999，265，1： | 1 |
| 10 | Osteonecrosis of the femoral head of laboratory anitools:The lessons learned from a comparative study of osteonecrosis in man and experimental animals 显示文摘 | Matsui M Ohzono K Nakamura N | 2003 | Vel Pathol2003，40，4： | 1 |
| 11 | Risk factors for subsequent development of bladder cancer after primary transitional cell carcinoma of the upper urinary tract显示文摘 | Matsui Y Utsunomiya N Ichioka K | 2005 | Urology2005，65，2： | 1 |
| 12 | Obsessive -- compulsive dis- order with poor insight显示文摘 | Matsunaga H Kiriike N Matsui T | 2002 | Comprehensive Psyehiatry2002，43，2： | 1 |
| 13 | Cat-CVD SiNpassivated AlGaN-GaN HFETs with thin and high Al composition barrier layers显示文摘 | Higashiwaki M Hirose N Matsui T | 2005 | IEEE Electron Device Letters2005，26，3： | 1 |
| 14 | Inactivation kinetics of polyphenol oxidase and peroxidase in green coconut water by microwave processing显示文摘 | MATSUI K N GUT A W DE OLIVERIRA P V | 2008 | Journal of Food Engineering2008，88，2： | 1 |
| 15 | An examination of qubit neural network in conlrolling an inverted pendulum显示文摘 | Kouda N Matsui N Nishimura H | 2005 | Neural Processing Letters2005，22，3： | 1 |
| 16 | A design approach for direct-drive permanent-magnet motors显示文摘 | Kano Y Matsui N | 2008 | IEEE Transactions on Industry Applications2008，44，2： | 1 |
| 17 | Blockade of macrophage migration inhibitory factor amel-iorates experimental autoimmune myocarditis显示文摘 | Matsui Y Okamoto H Jia N Akino M Uede T Kitabatake A | 2004 | J Mol CellCardiol2004，37，： | 1 |
| 18 | Heat shock suppresses membrane type 1-matrix metalloproteinase production and progelatinase A activation in human fibrosareoma HT-1080 cells and thereby inhibits cellular invasion显示文摘 | Sato T Sawaji Y Matsui N | 1999 | Biochem Biophys Res Commun1999，265，1： | 1 |
| 19 | The uptake trans?porter OATP8 expression decreases during multistep hepato?carcinogenesis: correlation with gadoxetic acid enhanced MR imaging显示文摘 | KITAO A MATSUI 0 YONEDA N | 2011 | Eur Radiol2011，21，10： | 1 |
| 20 | Refractory acquired hemophilia A successfully treated with CVP显示文摘 | Kaneko H Okada N Matsui Y | 2009 | Rinsho Ketsueki2009，50，： | 1 |
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