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| 1 | Oxidative stress: the lowest common denominator of multiple diseases显示文摘Oxygen is essential to the human life and life of all aerobic organisms. The complete oxidation of nutrients for the biological energy supply is one of the most important prerequisites for the formation of higher life forms. However, cells that benefit from oxidative respiration also suffer from reactive oxygen species because they adapted to oxygen as an energy source. Healthy cells balance the formation and elimination of reactive oxygen species thereby creating and keeping reactive oxygen species-homeostasis. When the concentration of free radicals exceeds a critical level and homeostasis is disturbed, oxidative stress occurs leading to damage of multiple cellular molecules and compartments. Therefore, oxidative stress plays an important role in the physiology and pathology of various diseases. Often, the antioxidant protection system becomes pathologically unbalanced in the genesis of several diseases, leading to functional losses of the organism, as in the case of amyotrophic lateral sclerosis, or cells develop metabolic mechanisms to use this system as protection against external influences, such as in the case of glioblastoma cells. Either way, understanding the underlying deregulated mechanisms of the oxidative protection system would allow the development of novel treatment strategies for various diseases. Thus, regardless of the direction in which the reactive oxygen species-homeostasis disequilibrate, the focus should be on the oxidative protection system. | Veronika Matschke Carsten Theiss Johann Matschke | 2019 | Neural Regeneration Research2019，14，2： | 7 |
| 2 | Influence of(22S, 23S)homobrassinolide on rooting capacity and survival of adult Norway spruce cutting显示文摘 | Ronsch H Adam G Matschke J | 1998 | Tree Physiology1998，12，： | 1 |
| 3 | Tigecycline pharmacokinetics in subjects with various degrees of renal function显示文摘 | Korth-Bradley JM Troy SM Matschke K | 2012 | J Clin Pharmacol2012，52，9： | 1 |
| 4 | The evaluation of potential pharmacokinetic interaction between sirolimus and ta- crolimus in healthy volunteers 显示文摘 | Tortorici MA Parks V Matschke K etal | 2013 | Eur J Clin Pharmacol2013，69，4： | 1 |
| 5 | Intracranial arteriovenous malformations presenting as sudden unexpected death:a report of 3 cases and review of the literature显示文摘 | Matschke J Lockemann U Schulz F | 2007 | Am J Forensic Med Pathol2007，28，2： | 1 |
| 6 | Pyeloureterostomy with interposition of the appendix显示文摘 | Jang TL Matschke HM Rubenstein JN | | 0，，05： | 1 |
| 7 | The effect of rifampin on the pharmacokinetics of sirolimus in healthy volunteers显示文摘 | Tortorici MA Matschke K Korth - Bradley JM etal | 2014 | Clinical Pharmacology in Drug Devel- opment2014，3，1： | 1 |
| 8 | Regulation of the myocardial microcircula- tion显示文摘 | Matschke K Jung K | 2008 | Clin Hemorheol Microcirc2008，39，： | 1 |
| 9 | Comparison of angle stable plate fixation approaches for distal radius fractures 显示文摘 | MATSCHKE S WENTZENSEN A RING D | 2011 | Injury2011，42，4： | 1 |
| 10 | Influence of systemichypothermia on the myocardial oxygen tension during extra-corporeal circulation ; comparative study in German Landracepigs显示文摘 | Matschke K Knaut M Kanig R | 2012 | Clin Hemorheol Microcirc2012，52，24： | 1 |
| 11 | Effect of an unrepaired fracture of the ulnar styloid base on outcome after plate-andscrew fixation of a distal radial fracture显示文摘 | Souer JS Ring D Matschke S | 2009 | J Bone Joint Surg Am2009，91，4： | 1 |
| 12 | The surgicaltreatment of unstable distal radius fractures by angle stableimplants:a multicenter prospective study显示文摘 | Matschke S Marent-Huber M Audigé L | | 0，，05： | 1 |
| 13 | Effects of progesterone on T-type-Ca^(2+)-channel expression in Purkinje cells显示文摘Plasticity of cerebellar Purkinje cells(PC)is influenced by progeste rone via the classical progeste rone receptors PR-A and PR-B by stimulating dendritogenesis,spinogenesis,and synaptogenesis in these cells.Dissociated PC cultures were used to analyze progeste rone effects at a molecular level on the voltage-gated T-type-Ca^(2+)-channels Ca_(v)3.1,Ca_(v)3.2,and Ca_(v)3.3 as they helped determine neuronal plasticity by regulating Ca^(2+)-influx in neuronal cells.The results showed direct effects of progesterone on the mRNA expression of T-type-Ca^(2+)-channels,as well as on the protein kinases A and C being involved in downstream signaling pathways that play an important role in neuronal plasticity.For the mRNA expression studies of T-type-Ca^(2+)-channels and protein kinases of the signaling cascade,laser microdissection and purified PC cultures of diffe rent maturation stages were used.Immunohistochemical staining was also performed to characte rize the localization of T-type-Ca^(2+)-channels in PC.Expe rimental progesterone treatment was performed on the purified PC culture for 24 and 48 hours.Our results show that progesterone increases the expression of Ca_(v)3.1 and Ca_(v)3.3 and associated protein kinases A and Cin PC at the mRNA level within 48 hours after treatment at latest.These effects extend the current knowledge of the function of progesterone in the central nervous system and provide an explanatory approach for its influence on neuronal plasticity. | Annika Eickhoff Jonas Tjaden Sarah Stahlke Matthias Vorgerd Verena Theis Veronika Matschke Carsten Theiss | 2022 | Neural Regeneration Research2022，17，11： | 1 |
| 14 | Pyeloureterostomy with interposition of the appendix 显示文摘 | Jang TL Matschke HM Rubenstein JN | 2002 | J Urol2002，168，5： | 1 |
| 15 | Level of soluble vascular endothelial growth factor (VEGF) recepter 1 in astrocytic tumors and its relation to malignancy, vascularity,and VEGF-A显示文摘 | Lamszus K Ulbricht U Matschke J | 2003 | Clin Cancer Res2003，9，4： | 1 |
| 16 | Changes in the content of indole-3-acetic acid and cytokinins in spruce, fir and oak trees after herbicide treatment 显示文摘 | Matschke J Machackov6 I | 2002 | Biologia Plantarum2002，45，： | 1 |
| 17 | Relaxin is a candidate drug for lung preservation: relaxin - induced protection of rat lungs from is- chemia - reperfusion injury 显示文摘 | Alexiou K Matschke K Westphal A | 2010 | J Heart Lung Transplant2010，29，4： | 1 |
| 18 | Safe efficacy of three strychnine alkaloid bait concentrations for hand-baiting control of plains pocket gophers显示文摘 | Ramey C A Matschke G H Hegdal P L | 2002 | Intern Biodeterior Biodegrad2002，49，： | 1 |
| 19 | Prosthetic valve endo- carditis : importance of surgical treatment 显示文摘 | Tugtekin S Matschke K Daubner D | 2007 | Thorac Cardiovasc Surg2007，55，： | 1 |
| 20 | C^oniparison of anglestable piate fixation approaches for distal radius fnu'tures 显示文摘 | Matschke S Wentzcnsen A Ring D | 2011 | Injury2011，42，4： | 1 |
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