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| 1 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 2 | Modeling the Effects of Residual Stresses on Defects in Welds of Steel Frame Connections 显示文摘 | Matos C G Dodds R H | 2001 | Engineering Structures2001，22，9： | 1 |
| 3 | ABCG2/BCRP gene expression is related to epithelial-mesenchy- mal transition inducer genes in a papillary thyroid carci- noma cell line (TPC-1) 显示文摘 | Mato g Gonzdlez C Moral A | 2014 | J Mol Endocrinol2014，5252，3： | 1 |
| 4 | Simultaneous follow-up of mouse colon lesions by colonoscopy and endoluminal ultrasound biomicroscopy显示文摘AIM:To evaluate the potential use of colonoscopy and endoluminal ultrasonic biomicroscopy(eUBM)to track the progression of mouse colonic lesions.METHODS:Ten mice were treated with a single azoxy-methane intraperitoneal injection(week 1)followed by seven days of a dextran sulfate sodium treatment in their drinking water(week 2)to induce inflammationassociated colon tumors.eUBM was performed simultaneously with colonoscopy at weeks 13,17-20 and21.A 3.6-F diameter 40 MHz mini-probe catheter was used for eUBM imaging.The ultrasound mini-probe catheter was inserted into the accessory channel of a pediatric flexible bronchofiberscope,allowing simultaneous acquisition of colonoscopic and eUBM images.During image acquisition,the mice were anesthetized with isoflurane and kept in a supine position over a stainless steel heated surgical waterbed at 37℃.Both eUBM and colonoscopic images were captured and stored when a lesion was detected by colonoscopy or when the eUBM image revealed a modified colon wall anatomy.During the procedure,the colon was irrigated with water that was injected through a flush port on the mini-probe catheter and that acted as the ultrasound coupling medium between the transducer and the colon wall.Once the acquisition of the last eUBM/colonoscopy section for each animal was completed,the colons were fixed,paraffin-embedded,and stained with hematoxylin and eosin.Colon images acquired at the first time-point for each mouse were compared with subsequent eUBM/colonoscopic images of the same sites obtained in the following acquisitions to evaluate lesion progression.RESULTS:All 10 mice had eUBM and colonoscopic images acquired at week 13(the first time-point).Two animals died immediately after the first imaging acquisition and,consequently,only 8 mice were subjected to the second eUBM/colonoscopy imaging acquisition(at the second time-point).Due to the advanced stage of colonic tumorigenesis,5 animals died after the second time-point image acquisition,and thus,only three were subjected to the third eUBM/colonoscopy imaging acquisition(the third time-point).eUBM was able to detect the four layers in healthy segments of colon:the mucosa(the first hyperechoic layer moving away from the mini-probe axis),followed by the muscularis mucosae(hypoechoic),the submucosa(the second hyperechoic layer)and the muscularis externa(the second hypoechoic layer).Hypoechoic regions between the mucosa and the muscularis externa layers represented lymphoid infiltrates,as confirmed by the corresponding histological images.Pedunculated tumors were represented by hyperechoic masses in the mucosa layer.Among the lesions that decreased in size between the first and third time-points,one of the lesions changed from a mucosal hyperplasia with ulceration at the top to a mucosal hyperplasia with lymphoid infiltrate and,finally,to small signs of mucosal hyperplasia and lymphoid infiltrate.In this case,while lesion regression and modification were observable in the eUBM images,colonoscopy was only able to detect the lesion at the first and second time-points,without the capacity to demonstrate the presence of lymphoid infiltrate.Regarding the lesions that increased in size,one of them started as a small elevation in the mucosa layer and progressed to a pedunculated tumor.In this case,while eUBM imaging revealed the lesion at the first time-point,colonoscopy was only able to detect it at the second time-point.All colonic lesions(tumors,lymphoid infiltrate and mucosal thickening)were identified by eUBM,while colonoscopy identified just76%of them.Colonoscopy identified all of the colonic tumors but failed to diagnose lymphoid infiltrates and increased mucosal thickness and failed to differentiate lymphoid infiltrates from small adenomas.During the observation period,most of the lesions(approximately67%)increased in size,approximately 14%remained unchanged,and 19%regressed.CONCLUSION:Combining eUBM with colonoscopy improves the diagnosis and the follow-up of mouse colonic lesions,adding transmural assessment of the bowel wall. | Rossana C Soletti Kelly Z Alves Marcelo AP de Britto Dyanna G de Matos Mnica Soldan Helena L Borges Joo C Machado | 2013 | World Journal of Gastroenterology2013，19，44： | 1 |
| 5 | Stimulation of Glutathione Synthesis of in Vitro Matured Bovine Oocytes and its Effect on Embryo Development and Freezability 显示文摘 | de Matos D G Furnus C C Moses D F | 1996 | M ol Reprod Dev1996，45，： | 1 |
| 6 | Effect of Cysteamine on Glutathione Level and Developmental Capacity of Bovine Oocyte Matured in Vitro显示文摘 | de Matos D G Furnus C C Moses D F | 1995 | Mol Reprod Dev1995，42，： | 1 |
| 7 | The hyaluronic acid receptor (CD44) is expressed in bovine oocytes and preimplantational stage embryos显示文摘 | Valcarcel A de Matos D G Furnus C C | 1999 | Theriogenology1999，51，： | 1 |
| 8 | Effect of hyaluronic acid on development of in vitro produced bovine enabryos 显示文摘 | FURNUS C C DE MATOS D G MARTINEZ A G | 1998 | Thefiogenology1998，49，： | 1 |
| 9 | Effect of hyaluronic acid on development of in vitro produced bovine embryos显示文摘 | Furnus C C de Matos D G Martinez A G | 1998 | Theriogenology1998，49，： | 1 |
| 10 | Probabilistic modeling of weld fracture in steel frame connections: part I:quasi- static loading 显示文摘 | Matos C G Dodds Jr R H | 2001 | Engineering Structures2001，23，8： | 1 |
| 11 | Simultaneous removal of perchlorate and nitrate from drinking water using the ion exchange membrane bioreactor concept显示文摘 | Matos C T Velizarov S Crespo J G | 2006 | Water Research2006，40，： | 1 |
| 12 | Association of African swine fever virus withthe cytoskeleton显示文摘 | CARVALHO Z G DE MATOS A P A RODRIGUES-POUSADA C | 1988 | Virus Res1988，11，2： | 1 |
| 13 | Modeling the effects of residual stresses on defects in welds of steel frame connections显示文摘 | MATOS C G DODDS R H | 2001 | Engineering Structures2001，22，9： | 1 |
| 14 | Probabilistic modeling of weld fracture in steel frame connections part 1: quasi-static loading显示文摘 | MATOS C G | 2001 | Engineering Structures2001，23，9： | 1 |
| 15 | Fiber Bragg grating (FBG) characterization and shaping by local pressure显示文摘 | MATOS C J S TORRES P VALENTE L C G | 2001 | J Lightwave Technol2001，19，8： | 1 |
| 16 | Multifunctional materials based on iron/iron oxide-filled carbon nanotubes/natural rubber composites 显示文摘 | Matos C F Galembeck F Zarbin A J G | 2012 | Carbon2012，50，12： | 1 |
| 17 | Sal- icifoliol, a new furolactone-type lignan from Bupleurum salicifolium 显示文摘 | GONZALEZ A G ESTEVEZ-REYES R MATO C | 1989 | Journal of Natural Products1989，52，5： | 1 |
| 18 | Speciation of Chromium in River Water Samples Contaminated with Leather Eflluents by Flame Atomic Absorption Spectrometry after Separation by Cloud Point Extraction显示文摘 | MATOS G D DOS REIS E B COSTA A C S | 2009 | Microchemistry Journal2009，92，2： | 1 |
| 19 | The importance of having high glutathione level after bovine in vitro maturation on embryo development: effect of b-mercaptoethanol, cysteine and cystine显示文摘 | Matos D G Furnus C C | 2000 | Theriogennlogy2000，53，3： | 1 |
| 20 | Fiber Bragg Grating(FBG) characterization and shaping by local presure显示文摘 | MATOS C J S TORRES P VALENTE L C G | 2001 | J Lightwave Technol2001，19，8： | 1 |
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