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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Beneficial effects of adenosine triphosphate-sensitive K^+ channel opener on liver ischemia/reperfusion injury显示文摘AIM:To investigate the effect of diazoxide administration on liver ischemia/reperfusion injury.METHODS:Wistar male rats underwent partial liver ischemia performed by clamping the pedicle from the medium and left anterior lateral segments for 1 h under mechanical ventilation.They were divided into 3 groups:Control Group,rats submitted to liver manipulation,Saline Group,rats received saline,and Diazoxide Group,rats received intravenous injection diazoxide(3.5 mg/kg) 15 min before liver reperfusion.4 h and 24 h after reperfusion,blood was collected for determination of aspartate transaminase(AST),alanine transaminase(ALT),tumor necrosis factor(TNF-α),interleukin-6(IL-6),interleukin-10(IL-10),nitrite/nitrate,creatinine and tumor growth factor-β1(TGF-β1).Liver tissues were assembled for mitochondrial oxidation and phosphorylation,malondialdehyde(MDA) content,and histologic analysis.Pulmonary vascular permeability and myeloperoxidase(MPO) were also determined.RESULTS:Four hours after reperfusion the diazoxide group presented with significant reduction of AST(2009 ± 257 U/L vs 3523 ± 424 U/L,P = 0.005); ALT(1794 ± 295 U/L vs 3316 ± 413 U/L,P = 0.005); TNF-α(17 ± 9 pg/mL vs 152 ± 43 pg/mL,P = 0.013; IL-6(62 ± 18 pg/mL vs 281 ± 92 pg/mL); IL-10(40 ± 9 pg/mL vs 78 ± 10 pg/mL P = 0.03),and nitrite/nitrate(3.8 ± 0.9 μmol/L vs 10.2 ± 2.4 μmol/L,P = 0.025) when compared to the saline group.A significant reduction in liver mitochondrial dysfunction was observed in the diazoxide group compared to the saline group(P < 0.05).No differences in liver MDA content,serum creatinine,pulmonary vascular permeability and MPO activity were observed between groups.Twenty four hours after reperfusion the diazoxide group showed a reduction of AST(495 ± 78 U/L vs 978 ± 192 U/L,P = 0.032); ALT(335 ± 59 U/L vs 742 ± 182 U/L,P = 0.048),and TGF-β1(11 ± 1 ng/mL vs 17 ± 0.5 ng/mL,P = 0.004) serum levels when compared to the saline group.The control group did not present alterations when compared to the diazoxide and saline groups.CONCLUSION:Diazoxide maintains liver mitochondrial function,increases liver tolerance to ischemia/reperfusion injury,and reduces the systemic inflammatory response.These effects require further evaluation for using in a clinical setting. | Mateus Antunes Nogueira Ana Maria Mendona Coelho Sandra Nassa Sampietre Rosely Antunes Patzina Fabiano Pinheiro da Silva Luiz Augusto Carneiro D'Albuquerque Marcel Cerqueira Cesar Machado | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 3 | Novel role of Egr-1 in nicotine-related neointimal formation显示文摘 | Vazquez-Padron RI Mateu D Rodriguez-Menocal L | 2010 | Cardiovasc Res2010，88，2： | 1 |
| 4 | 显示文摘 | Tadeu A Antonio J Mateus D | 2004 | Applied Acoustics2004，65，1： | 1 |
| 5 | Geographic Variation in Human Mitochondrial DNA Control Region Sequence:the Population History of Turkey and Its Relationship to the European Populations显示文摘 | Comas D Calafell F Mateu E | 1996 | Mol Biol Evol1996，13，： | 1 |
| 6 | Pneumococcal meningitis, cerebral venous thrombosis, and cervical arterial dissection: a run of bad luck? 显示文摘 | Panicio M I Foresto R D Mateus L et at | 2013 | Neurohospitalist2013，3，1： | 1 |
| 7 | Fragmentedlimestone wastes as a constructed wetland substrate for phosphorusremoval显示文摘 | MATEUS D M R VAZ M M N PINHO H J 0 | 2012 | Ecological Engineering2012，41，4： | 1 |
| 8 | Trading Genes along the Silk Road:mtDNA Sequences and the Origin of Central Asian Populations显示文摘 | Comas D Calafell F Mateu E | 1998 | Am J Hum Genet1998，63，： | 1 |
| 9 | Fragmented limestone wastes as a constructed wetland substmte for phosphorus removal 显示文摘 | Mateus D M R M M N Vaz H J O Pinho | 2012 | Ecological Engineering2012，41，： | 1 |
| 10 | Genetic diversity and phylogenetic analysis o{ glycoprotein 5 of European- type porcine reproductive and respiratory virus strains in Spain 显示文摘 | MATEU E MARTIN M VIDAL D | 2003 | J Gen Viro12003，84，： | 1 |
| 11 | Evolution of ORF5 of Span- ish porcine reproductive and respiratory syndrome virus strains from 1991 to 2005显示文摘 | Mateu E D'az I Darwich L | 2005 | Virus Research2005，19，： | 1 |
| 12 | Genetic diversity and phylogenetic analysis of glycoprotein 5 of European-- type porcine reproductive and respiratory syndrome virus strains in Spain显示文摘 | Mateu E Martin M Vidal D | 2003 | J Gen Virol2003，84，： | 1 |
| 13 | Human skeleton tracking from depth data using geodesic distances and optical flow显示文摘 | Schwarz L A Mkhitaryan A Mateus D | 2012 | Image and Vision Computing2012，30，3： | 1 |
| 14 | Direct evaluation of the immtmodominance of a major antigenic site of foot-and-mouth disease virus in a natural host 显示文摘 | Mateu M G Camareero J A Pmdreu D et ol | 1995 | Virology1995，205，： | 1 |
| 15 | Sound insulation provided by single and double panel walls: A comparison of analytical solutions versus experimental results 显示文摘 | Tadeu A Antonio J Mateus D | 2004 | Applied Acoustics2004，65，1： | 1 |
| 16 | Genetic diversity and phylogenetic analysis of glycoprotein 5 of European-type por cine reproductive and respiratory virus strains in Spain显示文摘 | MATEU E MARTIN M VIDAL D | 2003 | J Gen Viro12003，84，3： | 1 |
| 17 | Systematic replacement of amino acid residues within an Arg-Gly-Asp-con- talning loop of foot-and-mouth disease virus and effect on cell recognition显示文摘 | Mateu M G Valero M L Andreu D | 1996 | J Biol Chem1996，271，12： | 1 |
| 18 | Genetic diversity and phylogenetic analysis of glycoprotein 5 of European-type porcine reproductive and respiratory virus strains in Spain显示文摘 | Mateu E Martin M Vidal D | 2003 | J Gen Virol2003，84，3： | 1 |
| 19 | Human skeleton tracking from depth data using geodesic distances and optical flow 显示文摘 | Schwarz L A Mkhitaryan A Mateus D | 2012 | Image & Vision Computing2012，30，3： | 1 |
| 20 | Mitochondrial DNA Variation and the Origin of the Europeans显示文摘 | Comas D Calafell F Mateu E | 1997 | Hum Genet1997，99，4： | 1 |
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