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| 1 | Use of thiopurines in inflammatory bowel disease: Safety issues显示文摘Thiopurines are widely used for maintenance treatment of inflammatory bowel disease. Interindividual variability in clinical response to thiopurines may be attributed to several factors including genetic polymorphisms, severity and chronicity of disease, comorbidities, duration of administration, compliance issues and use of concomitant medication, environmental factors and clinician and patient preferences. The purpose of this review is to summarise the current evidence on thiopurine safety and toxicity, to describe adverse drug events and emphasise the significance of drug interactions, and to discuss the relative safety of thiopurine use in adults, elderly patients, children and pregnant women. Thiopurines are safe to use and well tolerated, however dose adjustment or discontinuation of treatment must be considered in cases of non-response, poor compliance or toxicity. Drug safety, clinical response to treatment and short to long term risks and benefits must be balanced throughout treatment duration for different categories of patients. Treatment should be individualised and stratified according to patient requirements. Enzymatic testing prior to treatment commencement is advised. Surveillance with regular clinic follow-up and monitoring of laboratory markers is important. Data on long term efficacy, safety of thiopurine use and interaction with other disease modifying drugs are lacking, especially in paediatric inflammatory bowel disease. High quality, collaborative clinical research is required so as to inform clinical practice in the future. | Anastasia Konidari Wael El Matary | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，2： | 3 |
| 2 | Integration of Representation into Goal-driven Behavior-Rased Robots 显示文摘 | Matarie M J | 1992 | IEEE Trans Robotics Automat1992，8，3： | 1 |
| 3 | An incremental self-deployment algorithm for mobile sensor networks 显示文摘 | HOWARD A MATARI' C M J SUKHATME G S | 2002 | Autonomous Robots2002，13，2： | 1 |
| 4 | A general, local algorithm for robot formations显示文摘 | Fredslund J Matari′c M J | 2002 | IEEE Trans on Robotics and Automation2002，18，5： | 1 |
| 5 | Localization for mobile robot teams: a distributed mle approach显示文摘 | HOWARD A MATARI' C M J SUKHATME G S | 2003 | Experimental Robotics2003，，8： | 1 |
| 6 | An incremental self-deployment algorithm for WSN显示文摘 | Howard A Matari M J Sukhatme G S | 2014 | Autonomous Robots2014，21，1： | 1 |
| 7 | A Formal Analysis and Taxonomy of Task Allocation in Muhi-Robot Systems 显示文摘 | BRIAN P GERKEY MAJA J MATARI C | 2004 | The International Journal of Robotics Research2004，23，9： | 1 |
| 8 | Omeprazole-induced hepatitis显示文摘 | Matary W Dalzell M | 2005 | Pediatr Emerg Care2005，21，8： | 1 |
| 9 | Behavior-based robotics as a tool for synthesis of artificial behavior and analysis of natural behavior显示文摘 | Matari? M J | 1998 | Trends in Cognitive Sciences1998，2，3： | 1 |
| 10 | Solitary pulmonary nodule in secondary syphilis 显示文摘 | Cholankeril JV Greenberg AL Matari HM | 1992 | Clin Imaging1992，16，2： | 1 |
| 11 | User—robot personality matching and assistive robot behavior adaptation for post-stroke rehabilitation therapy显示文摘 | Adriana Tapus Cristian ??pu? Maja J. Matari? | 2008 | Intelligent Service Robotics2008，，2： | 1 |
| 12 | Laser--Based People Tracking 显示文摘 | Ajo Fod Andrew Howard Maja J Matari'e | 2002 | ICRA2002，，： | 1 |
| 13 | Reinforcement learning in the multi-robot domain显示文摘 | Matari'c M J | 1997 | Autonomous Robots1997，4，1： | 1 |
| 14 | Extensive intracranial bilateral symmetrical calcification secondary to hypoparathyroidism显示文摘 | Jabr FI Matari HM Prempeh AL | 2004 | Arch Neurol2004，61，： | 1 |
| 15 | Aspects of the metabolism of hydrogen production by Rhodobacter sphaeroides显示文摘 | KO K H MATARY O | 2002 | Hydrogen Energy2002，27，11： | 1 |
| 16 | Solitary pulmonary nodule in secondary syphilis显示文摘 | Cholankeril JV Greenberg AL Matari HM | 1992 | Clin Imaging1992，16，12： | 1 |
| 17 | Integration of representation into goal_driven behavior_based robots 显示文摘 | | 1992 | IEEE Trans on Robotics and Automation1992，8，3： | 1 |
| 18 | An incremental self deployment algorithm for WSN显示文摘 | HOWARD A MATARI M J SUKHATME G S | 2014 | Au- tonomous Robots2014，21，1： | 1 |
| 19 | An Incremental Self-Deployment Algorithm for Mobile Sensor Networks 显示文摘 | Howard A Matari M J A G S S | 2002 | Autonomous Robots Special Issue on Intelligent Embedded Systems2002，13，2： | 1 |
| 20 | An incremental self deployment algorithm for mobile sensor networks 显示文摘 | HOWARD A MATARI'C M J SUKHATME G S | 2002 | Autonomous Robots2002，13，2： | 1 |
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