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126篇 您的检索式：作者名="MASATOSHI K"

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	题名	作者	年代	出处	被引量
1	Micromolar sodium fluoride mediates anti-osteoclastogenesis in Porphyromonas gingivalis-induced alveolar bone loss显示文摘Osteoclasts are bone-specific multinucleated cells generated by the differentiation of monocyte/macrophage lineage precursors.Regulation of osteoclast differentiation is considered an effective therapeutic approach to the treatment of bone-lytic diseases.Periodontitis is an inflammatory disease characterized by extensive bone resorption. In this study, we investigated the effects of sodium fluoride(Na F) on osteoclastogenesis induced by Porphyromonas gingivalis, an important colonizer of the oral cavity that has been implicated in periodontitis. Na F strongly inhibited the P. gingivalis-induced alveolar bone loss. That effect was accompanied by decreased levels of cathepsin K, interleukin(IL)-1β, matrix metalloproteinase 9(MMP9), and tartrate-resistant acid phosphatase,which were up-regulated during P. gingivalis-induced osteoclastogenesis. Consistent with the in vivo anti-osteoclastogenic effect,Na F inhibited osteoclast formation caused by the differentiation factor RANKL(receptor activator of nuclear factor kB ligand)and macrophage colony-stimulating factor(M-CSF). The RANKL-stimulated induction of the transcription factor nuclear factor of activated T cells(NFAT) c1 was also abrogated by Na F. Taken together, our data demonstrate that Na F inhibits RANKL-induced osteoclastogenesis by reducing the induction of NFATc1, ultimately leading to the suppressed expression of cathepsin K and MMP9.The in vivo effect of Na F on the inhibition of P. gingivalis-induced osteoclastogenesis strengthens the potential usefulness of Na F for treating periodontal diseases.	Ujjal K Bhawal Hye-Jin Lee Kazumune Arikawa Michiharu Shimosaka Masatoshi Suzuki Toshizo Toyama Takenori Sato Ryota Kawamata Chieko Taguchi Nobushiro Hamada Ikuo Nasu Hirohisa Arakawa Koh Shibutani	2015	International Journal of Oral Science2015，7，4：	3
2	Statin protects endothelial nitric oxide Synthase activity in hypoxia-induced pulmonary hypertension 显示文摘	TakahisaM Kazuya K Masatoshi H	2005	Arteriscler Thromb Vasc Biol2005，25，：	1
3	Small Hypervascular Hepatocellular Carcinoma Revealed by Double Arterial Phase CT Performed with Single Breath-Hold Scanning and Automatic Bolus Tracking显示文摘	Tonsok K Takamichi M Masatoshi H	2002	A JR2002，178，：	1
4	Chlorine distribution and structure property relationship of chlorinated polypropylene显示文摘	MITANI K OGATA T MASATOSHI I	1974	Jounal of Polymwe Science:Polymer Chemistry Edition1974，12，6：	1
5	Mulberry latex rich in antidiabetic sugar-mimic alkaloids forces dieting on caterpillars显示文摘	Kotaro K Hiroshi O Masatoshi N	2006	Proc Natl Acad Sci USA2006，103，5：	1
6	Microembolic signals and diffusion-weighted MR imaging abnormalities in acute ischemic stroke显示文摘	Kazuo M Masatoshi K	2001	Am J Neuroradiology2001，22，：	1
7	Fuzzy programming for multiobjective job shop scheduling with fuzzy processing time and fuzzy due-date through genetic algorithms显示文摘	Masatoshi S Ryo K	2000	European J of Operational Research2000，120，2：	1
8	Intraoperative measurements of nerve root blood flow during discectomy for lumbar disc herniation 显示文摘	Shinichi H Masatoshi N Masabim K	2003	Spine2003，1，：	1
9	Evaluation of the maximum potential activity of Co-Mo/Al2O3 catalysts for hydrodesulfurization显示文摘	YASUAKI O KEIJI O MASATOSHI K TAKESHI K	2004	J Catal2004，222，1：	1
10	Cooling load prediction in a district heating and cooling system through simplified robust filter and multilayered neural network 显示文摘	Kosuke K Ushiro S	2001	Applied Artificial Intelligence2001，15，7：	1
11	Operational planning of district heating and cooling plants through genetic algorithms for mixed 0-1 linear programming 显示文摘	Kosuke K Ushiro S	2002	European Journal of Operational Research2002，137，3：	1
12	Extremely low cycle fatigue life prediction based on a new cumulative fatigue damage model显示文摘	Masatoshi K	2001	International Journal of Fatigue2001，24，6：	1
13	Validation of particle size segregation of sintered ore during flowing through laboratory-scale chute by discrete element method显示文摘	Hiroshi M Satoshi K Masatoshi A	2008	ISIJ International2008，48，12：	1
14	Adrenal-preserving laparoscopic surgery in selected patients with bilateral adrenal tumors显示文摘	Masatoshi L Rumi S Akiko K	2003	Surgery2003，134，6：	1
15	Effect of chute angle on charging behavior of sintered ore particles at bell-less type charging system of blast furnace by discrete element method显示文摘	Hiroshi M Satoshi K Masatoshi A	2009	ISU International2009，49，4：	1
16	Strategics for surgical treatment of gallbladder carcinoma based on information available before resection 显示文摘	NORIHIRO K MASATOSHI M TAKESHI N	2005	Arch Surg2005，138，7：	1
17	Successful hepatic vein reconstruction in 42 consecutive living related liver transplantations显示文摘	Masatoshi M Tadatoshi M	2000	SURGERY2000，128，1：	1
18	Analysis of traveling behavior of nut coke particles in bell-type charging process of blast furnace by using discrete element method显示文摘	Hiroshi M Satoshi K Masatoshi A	2010	ISI I International2010，50，7：	1
19	Radiofrequency Ablation of Hepatocel- lular Carcinoma A Literature Review显示文摘	Yasunori M Masatoshi K	2011	International Journal of Hepatology2011，10，10：	1
20	Chlorine Distribution Property Relationship of Chlorinated Polypropylene显示文摘	MITANI K OGATA T MASATOSHI I	1974	Journal of polymwe science:Polymer Chemistry Edition1974，12，6：	1

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